scholarly journals Iron depletion-induced downregulation of N-cadherin expression inhibits invasive malignant phenotypes in human esophageal cancer

2016 ◽  
Vol 49 (4) ◽  
pp. 1351-1359 ◽  
Author(s):  
Seishi Nishitani ◽  
Kazuhiro Noma ◽  
Toshiaki Ohara ◽  
Yasuko Tomono ◽  
Shinichiro Watanabe ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Iron Depletion ◽  
Human Esophageal Cancer

Methylation of ZNF331 Promotes Cell Invasion and Migration in Human Esophageal Cancer

2015 ◽  
Vol 16 (4) ◽  
pp. 322-328 ◽  
Author(s):  
Suzhen Jiang ◽  
Enqiang Linghu ◽  
Qimin Zhan ◽  
Weidong Han ◽  
Mingzhou Guo
Keyword(s):  
Esophageal Cancer ◽  
Cell Invasion ◽  
Invasion And Migration ◽  
And Migration ◽  
Human Esophageal Cancer

scholarly journals Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ryoichi Katsube ◽  
Kazuhiro Noma ◽  
Toshiaki Ohara ◽  
Noriyuki Nishiwaki ◽  
Teruki Kobayashi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Near Infrared ◽  
Fibroblast Activation Protein ◽  
Therapeutic Resistance ◽  
Fibroblast Activation ◽  
Human Esophageal Cancer

AbstractCancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs have the multifunctionality which strongly support cancer progression and the acquisition of therapeutic resistance by cancer cells. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer treatment that uses a highly selective monoclonal antibody (mAb)-photosensitizer conjugate. We developed fibroblast activation protein (FAP)-targeted NIR-PIT, in which IR700 was conjugated to a FAP-specific antibody to target CAFs (CAFs-targeted NIR-PIT: CAFs-PIT). Thus, we hypothesized that the control of CAFs could overcome the resistance to conventional chemotherapy in esophageal cancer (EC). In this study, we evaluated whether EC cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by CAFs. Next, we assessed whether the resistance could be rescued by eliminating CAF stimulation by CAFs-PIT in vitro and in vivo. Cancer cells acquired chemoradiotherapy resistance via CAF stimulation in vitro and 5-fluorouracil (FU) resistance in CAF-coinoculated tumor models in vivo. CAF stimulation promoted the migration/invasion of cancer cells and a stem-like phenotype in vitro, which were rescued by elimination of CAF stimulation. CAFs-PIT had a highly selective effect on CAFs in vitro. Finally, CAF elimination by CAFs-PIT in vivo demonstrated that the combination of 5-FU and NIR-PIT succeeded in producing 70.9% tumor reduction, while 5-FU alone achieved only 13.3% reduction, suggesting the recovery of 5-FU sensitivity in CAF-rich tumors. In conclusion, CAFs-PIT could overcome therapeutic resistance via CAF elimination. The combined use of novel targeted CAFs-PIT with conventional anticancer treatments can be expected to provide a more effective and sensible treatment strategy.

scholarly journals Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1065
Author(s):  
Joseph-Hang Leung ◽  
Hong-Thai Nguyen ◽  
Shih-Wei Feng ◽  
Sofya B. Artemkina ◽  
Vladimir E. Fedorov ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Carrier Transport ◽  
X Ray Diffraction ◽  
Photoelectrochemical Response ◽  
Carrier Separation ◽  
Human Esophageal Cancer ◽  
P Type ◽  
Esophageal Cancer Cells

P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller photocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement.

scholarly journals Expression and biological role of DKK1 in human esophageal cancer

2011 ◽  
Vol 19 (20) ◽  
pp. 2116
Author(s):  
Shu-Jun Li ◽  
Yu-Zheng He ◽  
Bao-Lei Lv ◽  
Xiu-Lan Niu ◽  
Ai-Rong Cui ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Biological Role ◽  
Human Esophageal Cancer

Alvocidib (Flavopiridol) suppresses tumor growth in SCID mice with human esophageal cancer xenografts without inducing apoptosis

2006 ◽  
Vol 15 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Shinsuke Sato ◽  
Yoshiaki Kajiyama ◽  
Masahiko Sugano ◽  
Yoshimi Iwanuma ◽  
Hiroshi Sonoue ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Tumor Growth ◽  
Scid Mice ◽  
Human Esophageal Cancer

Apoptosis and autophagy induced by DVDMs-PDT on human esophageal cancer Eca-109 cells

2018 ◽  
Vol 24 ◽  
pp. 198-205 ◽  
Author(s):  
Yin Shi ◽  
Boli Zhang ◽  
Xiaolan Feng ◽  
Fei Qu ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Human Esophageal Cancer
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