scholarly journals Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells

2016 ◽  
Vol 48 (5) ◽  
pp. 1895-1906 ◽  
Author(s):  
YUKIO NISHIMURA ◽  
SUMIKO HYUGA ◽  
SOICHI TAKIGUCHI ◽  
MASASHI HYUGA ◽  
KAZUYUKI ITOH ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cancer Cells ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Hepatocyte Growth ◽  
Early Late ◽  
Endocytic Pathways

scholarly journals Human Lung Cancer Cell Line Producing Hepatocyte Growth Factor/Scatter Factor

1992 ◽  
Vol 83 (12) ◽  
pp. 1257-1261 ◽  
Author(s):  
Yasuteru Yoshinaga ◽  
Shin Fujita ◽  
Masahiro Gotoh ◽  
Toshikazu Nakamura ◽  
Masahiro Kikuchi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Human Lung ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Scatter Factor ◽  
Hepatocyte Growth

scholarly journals Growth-factor-dependent migration of human lung-cancer cells

1999 ◽  
Vol 82 (3) ◽  
pp. 338-345 ◽  
Author(s):  
Cecilia G. Bredin ◽  
Zhiwen Liu ◽  
Dan Hauzenberger ◽  
Julius Klominek
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals Prostasin regulates PD-L1 expression in human lung cancer cells

2021 ◽  
Vol 41 (7) ◽  
Author(s):  
Li-Mei Chen ◽  
Julius C. Chai ◽  
Bin Liu ◽  
Tara M. Strutt ◽  
K. Kai McKinstry ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Protein Kinase ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Human Lung ◽  
Negative Regulator ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Epidermal Growth

Abstract The serine protease prostasin is a negative regulator of lipopolysaccharide-induced inflammation and has a role in the regulation of cellular immunity. Prostasin expression in cancer cells inhibits migration and metastasis, and reduces epithelial–mesenchymal transition. Programmed death-ligand 1 (PD-L1) is a negative regulator of the immune response and its expression in cancer cells interferes with immune surveillance. The aim of the present study was to investigate if prostasin regulates PD-L1 expression. We established sublines overexpressing various forms of prostasin as well as a subline deficient for the prostasin gene from the Calu-3 human lung cancer cells. We report here that PD-L1 expression induced by interferon-γ (IFNγ) is further enhanced in cells overexpressing the wildtype membrane-anchored prostasin. The PD-L1 protein was localized on the cell surface and released into the culture medium in extracellular vesicles (EVs) with the protease-active prostasin. The epidermal growth factor-epidermal growth factor receptor (EGF-EGFR), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK) participated in the prostasin-mediated up-regulation of PD-L1 expression. A Gene Set Enrichment Analysis (GSEA) of patient lung tumors in The Cancer Genome Atlas (TCGA) database revealed that prostasin and PD-L1 regulate common signaling pathways during tumorigenesis and tumor progression.

Hepatocyte Growth Factor Promotes Tumor Growth in a NovelIn VivoModel of Human Lung Cancer

2001 ◽  
Vol 24 (5) ◽  
pp. 556-562 ◽  
Author(s):  
Joseph M. Pilewski ◽  
Thomas S. Bumbalo ◽  
Autumn Gaither Davis ◽  
Jill M. Siegfried
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tumor Growth ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Hepatocyte Growth

scholarly journals Interleukin-8/CXCL8 is a growth factor for human lung cancer cells

2004 ◽  
Vol 91 (11) ◽  
pp. 1970-1976 ◽  
Author(s):  
Y M Zhu ◽  
S J Webster ◽  
D Flower ◽  
P J Woll
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Lung ◽  
Interleukin 8 ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells
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