scholarly journals Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling

2016 ◽  
Vol 48 (4) ◽  
pp. 1590-1598 ◽  
Author(s):  
JIN-YAN ZHANG ◽  
MING-ZHE WENG ◽  
FANG-BIN SONG ◽  
YONG-GANG XU ◽  
QI LIU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Poor Prognosis ◽  
Proliferation And Invasion

Overexpressed long noncoding RNA Sox2ot predicts poor prognosis for cholangiocarcinoma and promotes cell proliferation and invasion

Gene ◽  
2018 ◽  
Vol 645 ◽  
pp. 131-136 ◽  
Author(s):  
Zhenglong Li ◽  
Jinglin Li ◽  
Daolin Ji ◽  
Kaiming Leng ◽  
Yi Xu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Poor Prognosis ◽  
Proliferation And Invasion

Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 6801-6812 ◽  
Author(s):  
Su-xiu Chen ◽  
Jun-feng Yin ◽  
Bao-chai Lin ◽  
Hua-fang Su ◽  
Zhen Zheng ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Proliferation And Invasion

scholarly journals Long Noncoding RNA RC3H2 Facilitates Cell Proliferation and Invasion by Targeting MicroRNA-101-3p/EZH2 Axis in OSCC

2020 ◽  
Vol 20 ◽  
pp. 97-110 ◽  
Author(s):  
Kun Wu ◽  
Yingying Jiang ◽  
Wenkai Zhou ◽  
Bolin Zhang ◽  
Yan Li ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Proliferation And Invasion

scholarly journals lncRNA MIAT promotes proliferation and invasion of HCC cells via sponging miR-214

2018 ◽  
Vol 314 (5) ◽  
pp. G559-G565 ◽  
Author(s):  
Xinli Huang ◽  
Yun Gao ◽  
Jianjie Qin ◽  
Sen Lu
Keyword(s):  
Myocardial Infarction ◽  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Histone Acetylation ◽  
Noncoding Rna ◽  
Micro Rna ◽  
Western Blot Assay ◽  
Aberrant Expression ◽  
Proliferation And Invasion ◽  
Hcc Cells

The aberrant expression of long noncoding RNAs (lncRNAs) has been involved in various human tumors including hepatocellular carcinoma (HCC). Our study aimed to investigate the potential molecular mechanism of lncRNA myocardial infarction-associated transcript (MIAT) in HCC. The expression of MIAT and micro-RNA (miR)-214 in HCC tissues and cells was examined by quantitative real-time PCR, and the levels of enhancer of zeste homolog 2 (EZH2) and β-catenin were detected by Western blot assay. Immunoprecipitation analysis was used to detect the level of H3/H4 histone acetylation. RNA pull-down assay was performed to confirm the targeting regulatory relationship between miR-214 and MIAT. Cell viability, proliferation, and invasion were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), [3H]thymidine incorporation, and Transwell assays, respectively. BALB/c nude mice were used to establish a hepatocellular carcinoma animal model with subcutaneous injection of SK-HEP-1 cells. Upregulation of MIAT is related to the proliferation and invasion of HCC, and downregulating MIAT expression inhibited HCC cell proliferation and invasion. The H3/H4 histone acetylation level of MIAT promoter in HCC tissues was higher than that in normal tissues. MIAT negatively regulated miR-214 in HCC cells. Inhibition of miR-214 reversed the influence of MIAT downregulation on HCC cell proliferation and invasion. In nude mouse xenograft models, downregulation of MIAT markedly suppressed the tumor growth of HCC via releasing miR-214. In conclusion, lncRNA MIAT promotes the proliferation and invasion of HCC cells through sponging miR-214, which brings a novel target for the therapy and prognosis of hepatocellular carcinoma. NEW & NOTEWORTHY This is the first research showing long noncoding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) to have a regulatory effect on hepatocellular carcinoma. Micro-RNA (miR)-214 could be sponged by MIAT to promote the proliferation and invasion of hepatocellular carcinoma cells. The lncRNA MIAT/miR-214 axis brings a novel insight for the therapy and prognosis of hepatocellular carcinoma.

Sign in / Sign up

Export Citation Format

Share Document