scholarly journals AP-2α inhibits hepatocellular carcinoma cell growth and migration

2016 ◽  
Vol 48 (3) ◽  
pp. 1125-1134 ◽  
Author(s):  
WENHUAN HUANG ◽  
CHENG CHEN ◽  
ZHONGHENG LIANG ◽  
JUNLU QIU ◽  
XINXIN LI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Cell Growth And Migration ◽  
Hepatocellular Carcinoma Cell ◽  
And Migration

Knockout of Ajuba Attenuates the Growth and Migration of Hepatocellular Carcinoma Cells

2020 ◽  
Vol 160 (11-12) ◽  
pp. 650-658
Author(s):  
Yichen Le ◽  
Yi He ◽  
Meirong Bai ◽  
Ying Wang ◽  
Jiaxue Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Cancer Progression ◽  
Normal Liver ◽  
Cell Growth And Migration ◽  
And Migration ◽  
Hcc Cells

Ajuba has been found to be mutated or aberrantly regulated in several human cancers and plays important roles in cancer progression via different signaling pathways. However, little is known about the role of Ajuba in hepatocellular carcinoma (HCC). Here, we found an upregulation of Ajuba expression in HCC tissues compared with normal liver tissues, while a poor prognosis was observed in HCC patients with high Ajuba expression. Knockout of Ajuba in HCC cells inhibited cell growth in vitro and in vivo, suppressed cell migration, and enhanced the cell apoptosis under stress. Moreover, re-expression of Ajuba in Ajuba-deficient cells could restore the phenotype of Ajuba-deficient cells. In conclusion, these results indicate that Ajuba is upregulated in HCC and promotes cell growth and migration of HCC cells, suggesting that Ajuba could possibly be a new target for HCC diagnosis and treatment.

scholarly journals NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferation

2017 ◽  
Vol 13 (3) ◽  
pp. 1587-1594 ◽  
Author(s):  
Xiao-Bo Lai ◽  
Yu-Qiang Nie ◽  
Hong-Li Huang ◽  
Ying-Fei Li ◽  
Chuang-Yu Cao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Cell Growth And Proliferation

miR-206-G6PD axis regulates lipogenesis and cell growth in hepatocellular carcinoma cell

2021 ◽  
Vol 32 (5) ◽  
pp. 508-516
Author(s):  
Ao Wang ◽  
Bocen Chen ◽  
Shaoqin Jian ◽  
Wangwei Cai ◽  
Man Xiao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell
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