scholarly journals Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

2015 ◽  
Vol 48 (1) ◽  
pp. 45-54 ◽  
Author(s):  
SHUNTARO MUKAI ◽  
SHOTA MORIYA ◽  
MASAKI HIRAMOTO ◽  
HIROMI KAZAMA ◽  
HIROKO KOKUBA ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Apoptotic Cell ◽  
Cancer Cell Lines ◽  
Apoptotic Cell Death ◽  
Autophagy Flux ◽  
Egfr Tki

Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines

1997 ◽  
Vol 116 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Yoshiya Kawaguchi ◽  
Hirohide Takebayashi ◽  
Akira Kakizuka ◽  
Shigeki Arii ◽  
Masayuki Kato ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Estrogen Receptor ◽  
Fusion Protein ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines

scholarly journals Gemcitabine-Based Chemoradiotherapy Enhanced by a PARP Inhibitor in Pancreatic Cancer Cell Lines

2021 ◽  
Vol 22 (13) ◽  
pp. 6825
Author(s):  
Waisse Waissi ◽  
Jean-Christophe Amé ◽  
Carole Mura ◽  
Georges Noël ◽  
Hélène Burckel
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Cancer Cell Lines ◽  
Human Pancreatic Cancer ◽  
High Dose

Pancreatic ductal adenocarcinoma is a devastating disease with a 5-year overall survival of 9% for all stages. Gemcitabine-based chemoradiotherapy for locally advanced pancreatic cancer is highly toxic. We conducted an in vitro study to determine whether poly(ADP-ribose) polymerase-1 inhibition radiosensitized gemcitabine-based chemotherapy. Human pancreatic cancer cell lines, MIA PaCa-2, AsPC-1, BxPC-3 and PANC-1 were treated with gemcitabine (10 nM) and/or olaparib (1 µM). Low-LET gamma single dose of 2, 5 and 10 Gy radiations were carried out. Clonogenic assay, PAR immunoblotting, cell cycle distribution, γH2Ax, necrotic and autophagic cell death quantifications were performed. Treatment with olaparib alone was not cytotoxic, but highly radiosensitized cell lines, particularly at high dose per fraction A non-cytotoxic concentration of gemcitabine radiosensitized cells, but less than olaparib. Interestingly, olaparib significantly enhanced gemcitabine-based radiosensitization in PDAC cell lines with synergistic effect in BxPC-3 cell line. All cell lines were radiosensitized by the combination of gemcitabine and olaparib, through an increase of unrepaired double-strand, a G2 phase block and cell death. Radiosensitization was increased with high dose of radiation. The combination of olaparib with gemcitabine-based chemoradiotherapy could lead to an enhancement of local control in vivo and an improvement in disease-free survival.

scholarly journals Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

1999 ◽  
Vol 79 (9-10) ◽  
pp. 1347-1355 ◽  
Author(s):  
A H Baker ◽  
S J George ◽  
A B Zaltsman ◽  
G Murphy ◽  
A C Newby
Keyword(s):  
Cell Death ◽  
Cell Lines ◽  
Cancer Cell ◽  
Apoptotic Cell ◽  
Cancer Cell Lines ◽  
Apoptotic Cell Death

scholarly journals Inhibition of CK2 enhances UV-triggered apoptotic cell death in lung cancer cell lines

2013 ◽  
Vol 30 (1) ◽  
pp. 377-384 ◽  
Author(s):  
TIESUO ZHAO ◽  
HUIJIE JIA ◽  
LIFEI LI ◽  
GUOLIANG ZHANG ◽  
MIN ZHAO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Cell Lines ◽  
Cancer Cell ◽  
Apoptotic Cell ◽  
Cancer Cell Lines ◽  
Apoptotic Cell Death ◽  
Lung Cancer Cell
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