scholarly journals SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells

2015 ◽  
Vol 47 (5) ◽  
pp. 1923-1931 ◽  
Author(s):  
SEONGEUN KANG ◽  
BYUNGTAK KIM ◽  
HAN-SUNG KANG ◽  
GOOKJOO JEONG ◽  
HANSOL BAE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Normal Breast ◽  
Proliferation Activity ◽  
Breast Cells

Leptin Induces a Proliferative Response in Breast Cancer Cells but Not in Normal Breast Cells

2014 ◽  
Vol 66 (4) ◽  
pp. 645-655 ◽  
Author(s):  
Virginie Dubois ◽  
Thierry Jardé ◽  
Laetitia Delort ◽  
Hermine Billard ◽  
Dominique Bernard-Gallon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Proliferative Response ◽  
Breast Cancer Cells ◽  
Normal Breast ◽  
Breast Cells

scholarly journals Vascular endothelial growth factor encoded by Parapoxviruses can regulate metabolism and survival of triple negative breast cancer cells

2020 ◽  
Vol 11 (11) ◽  
Author(s):  
Dipayan Bose ◽  
Sagarika Banerjee ◽  
Rajnish Kumar Singh ◽  
Lyn M. Wise ◽  
Erle S. Robertson
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Normal Breast ◽  
Cancer Breast ◽  
Human Genes ◽  
Metabolic Gene Expression ◽  
Breast Cells

AbstractDysbiotic microbiomes are linked to many pathological outcomes including different metabolic disorders like diabetes, atherosclerosis and even cancer. Breast cancer is the second leading cause of cancer associated death in women, and triple negative breast cancer (TNBC) is the most aggressive type with major challenges for intervention. Previous reports suggested that Parapoxvirus signatures are one of the predominant dysbiotic viral signatures in TNBC. These viruses encode several genes that are homologs of human genes. In this study, we show that the VEGF homolog encoded by Parapoxviruses, can induce cell proliferation, and alter metabolism of breast cancer and normal breast cells, through alteration of MAPK-ERK and PI3K-AKT signaling. In addition, the activity of the transcription factor FoxO1 was altered by viral-encoded VEGF through activation of the PI3K-AKT pathway, leading to reprogramming of cellular metabolic gene expression. Therefore, this study provides new insights into the function of viral-encoded VEGFs, which promoted the growth of the breast cancer cells and imparted proliferative phenotype with altered metabolism in normal breast cells.

Adhesion Between Anti-EphA2 Antibody-Coated AFM Tips and Breast Cancer Cells

2009 ◽  
Vol 1237 ◽  
Author(s):  
Emily Paetzell ◽  
Andrew Bogorad ◽  
Juan Meng ◽  
Winston oluwole Soboyejo
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Adhesion Force ◽  
Normal Breast ◽  
Atomic Force ◽  
Afm Tips ◽  
Ligand Interactions ◽  
Breast Cells ◽  
Adhesive Interactions

AbstractThis paper presents the results of atomic force microscope (AFM) measurements of the adhesion force between MDA-MB-231 breast cancer cells and anti-EphA2 antibody-coated AFM tips. As a control, the adhesive interactions are measured between Hs578Bst normal breast cells and anti-EphA2 antibody-coated AFM tips. The measurements show conclusively that the adhesive forces to breast cancer cells are over five times greater than those to normal breast cells. The increase is attributed largely to the interactions between anti-EphA2 antibody and over-expressed EphA2 receptors that are revealed by the staining of receptor-ligand interactions. The implications of the results are discussed for the localized targeting and treatment of cancer with antibody-conjugated nanoparticles.

Normal breast epithelial cells induce p53-dependent apoptosis and p53-independent cell cycle arrest of breast cancer cells

2002 ◽  
Vol 71 (3) ◽  
pp. 269-280 ◽  
Author(s):  
Robert-Alain Toillon ◽  
Valérie Chopin ◽  
Nathalie Jouy ◽  
William Fauquette ◽  
Bénoni Boilly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Epithelial Cells ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Normal Breast ◽  
Breast Epithelial Cells ◽  
Cycle Arrest ◽  
Normal Breast Epithelial Cells
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