scholarly journals EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition

2015 ◽  
Vol 47 (2) ◽  
pp. 499-505 ◽  
Author(s):  
TAKURO MIZUKAMI ◽  
YOSUKE TOGASHI ◽  
SHUNSUKE SOGABE ◽  
ERI BANNO ◽  
MASATO TERASHIMA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mek Inhibition

Prolonged MEK inhibition leads to acquired resistance and increased invasiveness in KRAS mutant gastric cancer

2018 ◽  
Vol 507 (1-4) ◽  
pp. 311-318 ◽  
Author(s):  
Kyoung-Min Choi ◽  
Eunji Cho ◽  
Eunjung Kim ◽  
Jong Hwan Shin ◽  
Minju Kang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Acquired Resistance ◽  
Mek Inhibition

scholarly journals MEK Inhibition Suppresses Metastatic Progression of KRAS ‐Mutated Gastric Cancer

2021 ◽  
Author(s):  
Juntaro Yamasaki ◽  
Yuki Hirata ◽  
Yuji Otsuki ◽  
Kentaro Suina ◽  
Yoshiyuki Saito ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Metastatic Progression ◽  
Mek Inhibition

scholarly journals Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells

2016 ◽  
Vol 107 (12) ◽  
pp. 1919-1928 ◽  
Author(s):  
Yuka Hirashita ◽  
Yoshiyuki Tsukamoto ◽  
Kazuyoshi Yanagihara ◽  
Shoichi Fumoto ◽  
Naoki Hijiya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Ribosomal Protein ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Mek Inhibition ◽  
Ribosomal Protein S6

MEK inhibition overcomes everolimus resistance in gastric cancer

2020 ◽  
Vol 85 (6) ◽  
pp. 1079-1087
Author(s):  
Hongfang Liu ◽  
Yang Yao ◽  
Juan Zhang ◽  
Jing Li
Keyword(s):  
Gastric Cancer ◽  
Mek Inhibition

scholarly journals EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition

2015 ◽  
Vol 26 ◽  
pp. vii129
Author(s):  
Takuro Mizukami ◽  
Yosuke Togashi ◽  
Shunsuke Sogabe ◽  
Marco A de Velasco ◽  
Kazuko Sakai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mek Inhibition

scholarly journals Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiaoxuan Wang ◽  
Yoshiyuki Yamamoto ◽  
Mamiko Imanishi ◽  
Xiaochen Zhang ◽  
Masashi Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
G1 Arrest ◽  
Wild Type ◽  
Gastric Cancer Cells ◽  
Mek Inhibition

Ultrastructural Cytochemical Study of Human Gastric Cancer: Observation of AKP ase,ACP ase,G6P ase,TPP ase and CO ase

1990 ◽  
Vol 48 (3) ◽  
pp. 254-255
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Du Wei Dong ◽  
Xu Ai Liam
Keyword(s):  
Gastric Cancer ◽  
Gastric Epithelium ◽  
Human Gastric Cancer ◽  
Electron Microscopic ◽  
Cytochemical Study ◽  
Electron Microscopic Cytochemistry ◽  
Cytochemical Reaction ◽  
Set Up ◽  
Cancer Tissues ◽  
Cytochemical Technique

The activities and distributions of AKPase ,ACPase,G6Pase,TPPase and COase in human normal gastric mucosa and gastric cancer tissues were studied histochemically at light microscopic level. These enzymes are the marker enzymes of cell membrane lysosome endoplasmic reticulum, Golgi apparatus and mitochondrion objectively. On the basis of the research we set up a special ultrastructural cytochemical technique and first researched into gastric cancer domesticly. Ultrastructural cytochemistry is also called electron microscopic cytochemistry. This new technique possesses both the sensitivity of cytochemical reaction andi the high resolution of electron microscope. It is characterized by direct observation,exact localization and the combination morphology with function.The distributions of AKPase,ACPase,G6Pase,TPPase and COase in 14 cases of gastric cancer and 1 case of gastric Denign lesion were studied ultrastructurally. The results showed: 1. normal gastric epithelium had no AKPase reaction. The reaction of ACPase,G6Pase,TPPase and Coase were found in the corresponding organella, which were consistent with their function.

Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

1990 ◽  
Vol 48 (3) ◽  
pp. 252-253
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Wu Jifeng ◽  
Chen Xiaolin
Keyword(s):  
Gastric Cancer ◽  
Intestinal Metaplasia ◽  
Cancer Cells ◽  
Microscopic Observation ◽  
Biological Significance ◽  
Ultrastructural Localization ◽  
Mucinous Carcinoma ◽  
Surface Glycoprotein ◽  
Tubular Adenocarcinoma ◽  
Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

Reduced expression of TMEM166 is associated with esophageal carcinoma and gastric cancer

2010 ◽  
Vol 34 (8) ◽  
pp. S54-S54
Author(s):  
Dong Xu ◽  
Ying Chang ◽  
Huiying He ◽  
Yingyu Chen
Keyword(s):  
Gastric Cancer ◽  
Esophageal Carcinoma

Effect of Chrysanthemum flavonoids on growth and cell cycle regulators of gastric cancer cell

2010 ◽  
Vol 34 (8) ◽  
pp. S50-S50
Author(s):  
Xiaoyan Pan ◽  
Xinmei Zhou ◽  
Guangtao Xu ◽  
Lingfen Miao ◽  
Shuoru Zhu
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cell Cycle Regulators
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