scholarly journals Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro

2015 ◽  
Vol 46 (4) ◽  
pp. 1677-1684 ◽  
Author(s):  
SONGSHU XIAO ◽  
YANHONG ZHOU ◽  
WEI YI ◽  
GUIJUAN LUO ◽  
BIN JIANG ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cervical Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
P53 Signaling ◽  
Cancer Tissues ◽  
P53 Signaling Pathway

scholarly journals A novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (27) ◽  
pp. 41843-41856 ◽  
Author(s):  
Pinghong Ming ◽  
Ting Cai ◽  
Jin Li ◽  
Yong Ning ◽  
Shengao Xie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cyclin A ◽  
Cervical Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Lei ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Tumor Formation ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Bioinformatics Analyses

AbstractHomeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.

scholarly journals β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling

2015 ◽  
Vol 10 (6) ◽  
pp. 3434-3442 ◽  
Author(s):  
DAN LU ◽  
JING QIAN ◽  
WEI LI ◽  
QIANQIAN FENG ◽  
SHU PAN ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Mtor Signaling ◽  
Cervical Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer
Sign in / Sign up

Export Citation Format

Share Document