scholarly journals Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway

2014 ◽  
Vol 45 (5) ◽  
pp. 1969-1976 ◽  
Author(s):  
SOON-JAE KWON ◽  
JU-HYE LEE ◽  
KWANG-DEOG MOON ◽  
IL-YUN JEONG ◽  
SUNG-TAE YEE ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Akt Pathway ◽  
Apoptotic Pathway ◽  
Mitochondrial Apoptotic Pathway ◽  
Human Melanoma Cells

scholarly journals The Efficacy of Dandelion Root Extract in Inducing Apoptosis in Drug-Resistant Human Melanoma Cells

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
S. J. Chatterjee ◽  
P. Ovadje ◽  
M. Mousa ◽  
C. Hamm ◽  
S. Pandey
Keyword(s):  
Surgical Excision ◽  
Natural Compounds ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Root Extract ◽  
Nuclear Condensation ◽  
Apoptotic Pathway ◽  
Outer Leaflet ◽  
Human Melanoma Cells ◽  
A375 Cells

Notoriously chemoresistant melanoma has become the most prevalent form of cancer for the 25–29 North American age demographic. Standard treatment after early detection involves surgical excision (recurrence is possible), and metastatic melanoma is refractory to immuno-, radio-, and most harmful chemotherapies. Various natural compounds have shown efficacy in killing different cancers, albeit not always specifically. In this study, we show that dandelion root extract (DRE) specifically and effectively induces apoptosis in human melanoma cells without inducing toxicity in noncancerous cells. Characteristic apoptotic morphology of nuclear condensation and phosphatidylserine flipping to the outer leaflet of the plasma membrane of A375 human melanoma cells was observed within 48 hours. DRE-induced apoptosis activates caspase-8 in A375 cells early on, demonstrating employment of an extrinsic apoptotic pathway to kill A375 cells. Reactive Oxygen Species (ROS) generated from DRE-treated isolated mitochondria indicates that natural compounds in DRE can also directly target mitochondria. Interestingly, the relatively resistant G361 human melanoma cell line responded to DRE when combined with the metabolism interfering antitype II diabetic drug metformin. Therefore, treatment with this common, yet potent extract of natural compounds has proven novel in specifically inducing apoptosis in chemoresistant melanoma, without toxicity to healthy cells.

Luteolin inhibits proliferation and induces apoptosis of human melanoma cells in vivo and in vitro by suppressing MMP-2 and MMP-9 through the PI3K/AKT pathway

2019 ◽  
Vol 10 (2) ◽  
pp. 703-712 ◽  
Author(s):  
Xin Yao ◽  
Wei Jiang ◽  
Danhong Yu ◽  
Zhaowei Yan
Keyword(s):  
Malignant Melanoma ◽  
Incidence Rate ◽  
Melanoma Cell ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Akt Pathway ◽  
Human Melanoma Cells ◽  
Cell Metastasis

Since the incidence rate of malignant melanoma is increasing annually, development of drugs against melanoma cell metastasis has become more urgent.

Nitric Oxide Activates the PI3Kinase-Akt Pathway in Human Melanoma Cells

2016 ◽  
Vol 100 ◽  
pp. S120
Author(s):  
Zhen Ding ◽  
Yong Qin ◽  
Sun-Hee Kim ◽  
Elizabeth A. Grimm
Keyword(s):  
Nitric Oxide ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Akt Pathway ◽  
Human Melanoma Cells

scholarly journals UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway

2018 ◽  
Author(s):  
Xueli Shi ◽  
Liu Yang ◽  
Jun Xie ◽  
Yumei Zhao ◽  
Junzi Cong ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Akt Pathway ◽  
Human Melanoma Cells

Erythropoietin activates the phosphoinositide 3-kinase/Akt pathway in human melanoma cells

2006 ◽  
Vol 16 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Suresh M. Kumar ◽  
Hong Yu ◽  
Dong Fong ◽  
Geza Acs ◽  
Xiaowei Xu
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Akt Pathway ◽  
Human Melanoma Cells ◽  
Phosphoinositide 3 Kinase

Adipocytes Contribute to Resistance of Human Melanoma Cells to Chemotherapy and Targeted Therapy

2014 ◽  
Vol 21 (10) ◽  
pp. 1255-1267 ◽  
Author(s):  
M. Chi ◽  
J. Chen ◽  
Y. Ye ◽  
Hsin-Yi Tseng ◽  
F. Lai ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells
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