scholarly journals Genomic copy number alterations associated with the early brain metastasis of non-small cell lung cancer

2012 ◽  
Vol 41 (6) ◽  
pp. 2013-2020 ◽  
Author(s):  
HYE WON LEE ◽  
HO JUN SEOL ◽  
YOON-LA CHOI ◽  
HYUN JUNG JU ◽  
KYEUNG MIN JOO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastasis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Small Cell ◽  
Copy Number Alterations ◽  
Small Cell Lung ◽  
Genomic Copy Number ◽  
Genomic Copy

scholarly journals Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88300 ◽  
Author(s):  
Bi-Qing Li ◽  
Jin You ◽  
Tao Huang ◽  
Yu-Dong Cai
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Small Cell ◽  
Copy Number Alterations ◽  
Small Cell Lung

scholarly journals Mutation analysis and copy number alterations of KIF23 in non-small-cell lung cancer exhibiting KIF23 over-expression

2017 ◽  
Vol Volume 10 ◽  
pp. 4969-4979 ◽  
Author(s):  
Ann-Louise Vikberg ◽  
Tõnu Vooder ◽  
Kaie Lokk ◽  
Tarmo Annilo ◽  
Irina Golovleva
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Mutation Analysis ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Small Cell ◽  
Copy Number Alterations ◽  
Small Cell Lung ◽  
Over Expression

Abstract 1214: TP53 affects SOX2 copy number alterations and expression in non-small cell lung cancer

2015 ◽  
Author(s):  
Johanna Samulin-Erdem ◽  
Vidar Skaug ◽  
Per Bakke ◽  
Amund Gulsvik ◽  
Aage Haugen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Small Cell ◽  
Copy Number Alterations ◽  
Small Cell Lung

Genomic copy number alterations in non-small cell lung cancers identified using CBS and MSA

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 7695-7695
Author(s):  
M. S. Park ◽  
C. Ma ◽  
M. U. Aziz ◽  
S. Rao ◽  
K. Gold ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Hierarchical Clustering ◽  
Copy Number ◽  
Female Gender ◽  
Small Cell ◽  
Clinical Parameters ◽  
Copy Number Alterations ◽  
Small Cell Lung ◽  
Genomic Copy Number ◽  
Genomic Copy

7695 Background: Lung cancer is the leading cause of cancer death in both men and women with a 5-yr survival rate of 15.5%. Previous studies have begun to characterized genomic copy number alterations of non-small-cell lung CA using array CGH and SNP arrays. We have used aCGH using our 1MB BAC arrays and two algorthims for making copy number alteration (CNA) determinations. We have also pursued the exact copy number gains and losses of several genes using Q-PCR. Methods: Genomic DNA from fresh frozen tumors of 27 patients with NSCLC. We performed aCGH using 1MB Arrays. We used CBS, and MSA to identify regions of CNA. We further pursued several genes of interest (including HRAS, CRK, and CDC42) identified using Q-PCR. Unsupervised hierarchical clustering was performed to look for distinct subgroups. Significant Analysis of Microarrays (SAM) was applied to identify the association between CNAs clinical parameters including tumor subtype, gender, lymph node involvement, tumor stage, and overall survival. Results: 240 regions of amplification and 181 regions of deletions were found, and included all previously published regions implicated in lung cancer. CNAs in > 70% of tumors included amplifications in 1q, 3q, 5p, 6p, 11p, 16q, 20q, and Xq, and deletions in 1p, 8p and 13q. We verified CNAs of HRAS, CRK and CDC42 using Q-PCR. Hierarchical clustering revealed 2 subgroups: one with amplifications in 2q, 4p, 4q, 8q, 21q, 15q, and 16p, and the other with amplifications in 3q, and 5q. These were confirmed by supervised SAM analysis. Using SAM we found that gain of 2q, 4p and 10q, and loss of 16p and 19q were significantly present in adenocarcinomas. (q = 0, FDR = 0%). Gain of 10q, and loss of 6p and 14q were associated with female gender. (q = 0, FDR = 0%). Conclusions: We used aCGH to identify CNAs that characterize non-small cell lung CA tumors with the aim of finding key regions which may harbor important oncogenes and tumor suppressors. Several regions of CNA have been identified, several of which have been associated with clinical parameters. Because much heterogeneity exists in non-small-cell lung tumors, we have demonstrated that clustering analysis is useful in identifying subtypes which may possess prognostic and therapeutic significance. No significant financial relationships to disclose.

scholarly journals Impact on Disease Development, Genomic Location and Biological Function of Copy Number Alterations in Non-Small Cell Lung Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e22961 ◽  
Author(s):  
Yen-Tsung Huang ◽  
Xihong Lin ◽  
Lucian R. Chirieac ◽  
Ray McGovern ◽  
John C. Wain ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Biological Function ◽  
Small Cell ◽  
Disease Development ◽  
Copy Number Alterations ◽  
Small Cell Lung ◽  
Genomic Location

scholarly journals P1.05-011 Comparative Analysis of TTF-1 Copy Number Alterations and Protein Expression in Patients with Non-Small Cell Lung Cancer

2017 ◽  
Vol 12 (1) ◽  
pp. S619-S620
Author(s):  
Katsuhiro Yoshimura ◽  
Yusuke Inoue ◽  
Nobuya Kurabe ◽  
Tomoaki Kahyo ◽  
Akikazu Kawase ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Comparative Analysis ◽  
Protein Expression ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Small Cell ◽  
Copy Number Alterations ◽  
Small Cell Lung

Abstract LB-146: Identification of copy number alterations in small cell lung cancer

2010 ◽  
Author(s):  
Alison L. Dooley ◽  
Monte M. Winslow ◽  
Derek Chiang ◽  
Shantanu Banerji ◽  
Charles Whittaker ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Small Cell ◽  
Copy Number Alterations ◽  
Small Cell Lung

Abstract 2132: Cigarette smoking increases copy number alterations in non-small cell lung cancer

2010 ◽  
Author(s):  
Yen-Tsung Huang ◽  
Xihong Lin ◽  
Lucian R. Chirieac ◽  
Ray McGovern ◽  
John C. Wain ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cigarette Smoking ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Small Cell ◽  
Copy Number Alterations ◽  
Small Cell Lung
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