scholarly journals Parthenolide suppresses tumor growth in a xenograft model of colorectal cancer cells by inducing mitochondrial dysfunction and apoptosis

2012 ◽  
Vol 41 (4) ◽  
pp. 1547-1553 ◽  
Author(s):  
SE-LIM KIM ◽  
KIEU THE THU TRANG ◽  
SEONG HUN KIM ◽  
IN HEE KIM ◽  
SEUNG OK LEE ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Xenograft Model ◽  
Colorectal Cancer Cells

scholarly journals Utidelone inhibits growth of colorectal cancer cells through ROS/JNK signaling pathway

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Fuli Li ◽  
Tinglei Huang ◽  
Yao Tang ◽  
Qingli Li ◽  
Jianzheng Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Xenograft Model ◽  
Jnk Pathway ◽  
Epothilone B ◽  
Colorectal Cancer Cells ◽  
M Phase ◽  
Jnk Signaling Pathway ◽  
Microtubule Stabilizing Agent

AbstractUtidelone (UTD1), a novel microtubule stabilizing agent, is an epothilone B analogue which was produced by genetic engineering. UTD1 has exhibited broad antitumor activity in multiple solid tumors. However, its activity and mechanism in colorectal cancer (CRC) remain to be studied. In this study, UTD1 dramatically inhibited CRC cell proliferation (with 0.38 µg/ml, 0.77 µg/ml IC50 in RKO and HCT116, respectively) in vitro. Immunofluorescence staining showed that UTD1 induced the formation of microtubule bundling and asters in RKO cells. Flow cytometry analysis demonstrated that UTD1 induced cell cycle to arrest in G2/M phase, subsequent apoptosis. Significantly, UTD1 exhibited stronger effect on inducing apoptosis than paclitaxel and 5-FU, especially in HCT15 cells which is ABCB1 high-expression. UTD1 exposure cleaved caspase-3 and poly ADP-ribose polymerase (PARP), decreased mitochondrial membrane potential, released cytochrome c, increased the production of active oxygen and activated c-Jun N-terminal kinase (JNK), suggesting ROS/JNK pathway was involved in this process. Moreover, UTD1 inhibited tumor growth and was more effective and safer compared with paclitaxel and 5-FU in RKO xenograft in nude mice. Taken together, our findings first indicate that UDT1 inhibits tumor growth in CRC xenograft model and may be a promising agent for CRC treatment.

scholarly journals Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth

2018 ◽  
Vol 9 ◽  
Author(s):  
Ana S. Pires ◽  
Cláudia R. Marques ◽  
João C. Encarnação ◽  
Ana M. Abrantes ◽  
Inês A. Marques ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ascorbic Acid ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Colorectal Cancer Cells

scholarly journals GNA13 promotes tumor growth and angiogenesis by upregulating CXC chemokines via the NF-κB signaling pathway in colorectal cancer cells

2018 ◽  
Vol 7 (11) ◽  
pp. 5611-5620 ◽  
Author(s):  
Zhongqiang Zhang ◽  
Xiao Tan ◽  
Jing Luo ◽  
Beibei Cui ◽  
Sanlin Lei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colorectal Cancer Cells
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