scholarly journals Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma

2012 ◽  
Vol 41 (2) ◽  
pp. 573-582 ◽  
Author(s):  
KOICHI OKAMOTO ◽  
HIDEHIRO TAJIMA ◽  
SHINICHI NAKANUMA ◽  
SEISHO SAKAI ◽  
ISAMU MAKINO ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Intrahepatic Cholangiocarcinoma ◽  
Hepatic Stellate Cells ◽  
Stromal Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Stellate Cells ◽  
Mesenchymal Transition ◽  
Activated Hepatic Stellate Cells ◽  
Stromal Cell Derived Factor ◽  
Cxcr4 Axis

scholarly journals Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor-1α-mediated stellate cell activation

Hepatology ◽  
2009 ◽  
Vol 49 (6) ◽  
pp. 2055-2067 ◽  
Author(s):  
Feng Hong ◽  
Ana Tuyama ◽  
Ting Fang Lee ◽  
Johnny Loke ◽  
Ritu Agarwal ◽  
...  
Keyword(s):  
Hepatic Stellate Cells ◽  
Stromal Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Stellate Cells ◽  
Stromal Cell Derived Factor

scholarly journals Fuzheng Huayu Recipe Ameliorates Liver Fibrosis by Restoring Balance between Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Hepatic Stellate Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Qin Pan ◽  
Yu-Qin Wang ◽  
Guang-Ming Li ◽  
Xiao-Yan Duan ◽  
Jian-Gao Fan
Keyword(s):  
Liver Fibrosis ◽  
P38 Mapk ◽  
Hepatic Stellate Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Stellate Cells ◽  
Cordyceps Sinensis ◽  
Dependent Manner ◽  
Radix Salviae Miltiorrhizae ◽  
Mesenchymal Transition ◽  
Mesenchymal To Epithelial Transition

Activation of hepatic stellate cells (HSCs) depending on epithelial-to-mesenchymal transition (EMT) reflects the key event of liver fibrosis. Contrastively, mesenchymal-to-epithelial transition (MET) of HSCs facilitates the fibrosis resolution. Here we investigated the effect of Fuzheng Huayu (FZHY) recipe, a Chinese herbal decoction made ofRadix Salviae Miltiorrhizae,Semen Persicae,Cordyceps sinensis,Pollen Pini, andGynostemma pentaphyllum, on liver fibrosis concerning the balance of EMT and MET in HSCs. In contrast to the increased TGF-β1/BMP-7 ratio in activated HSCs, FZHY administration induced significant upregulation of BMP-7 and downregulation of TGF-β1at both transcription and translation levels. Restoration of TGF-β1/BMP-7 ratio inhibited the expression of p38 MAPK and phosphorylated p38 MAPK, resulting in the reversal of epithelial-to-mesenchymal transition (EMT) to mesenchymal-to-epithelial transition (MET) as characterized by the abolishment of EMT markers (α-SMA and desmin) and reoccurrence of MET marker (E-cadherin).In vivotreatment of FZHY recipe also demonstrated the statistical reduction of activated HSCs with EMT phenotype, which attenuated the carbon tetrachloride- (CCl4-) induced liver fibrosis in a dose-dependent manner. These findings may highlight a novel antifibrotic role of FZHY recipe on the basis of rebalancing EMT and MET in HSCs.

scholarly journals Evidence for and against epithelial-to-mesenchymal transition in the liver

2013 ◽  
Vol 305 (12) ◽  
pp. G881-G890 ◽  
Author(s):  
Guanhua Xie ◽  
Anna Mae Diehl
Keyword(s):  
Liver Injury ◽  
Epithelial Cells ◽  
Hepatic Stellate Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Stellate Cell ◽  
Stellate Cells ◽  
Mesenchymal Cells ◽  
Mesenchymal Transition ◽  
Liver Epithelial Cells ◽  
Liver Repair

The outcome of liver injury is determined by the success of repair. Liver repair involves replacement of damaged liver tissue with healthy liver epithelial cells (including both hepatocytes and cholangiocytes) and reconstruction of normal liver structure and function. Current dogma posits that replication of surviving mature hepatocytes and cholangiocytes drives the regeneration of liver epithelium after injury, whereas failure of liver repair commonly leads to fibrosis, a scarring condition in which hepatic stellate cells, the main liver-resident mesenchymal cells, play the major role. The present review discusses other mechanisms that might be responsible for the regeneration of new liver epithelial cells and outgrowth of matrix-producing mesenchymal cells during hepatic injury. This theory proposes that, during liver injury, some epithelial cells undergo epithelial-to-mesenchymal transition (EMT), acquire myofibroblastic phenotypes/features, and contribute to fibrogenesis, whereas certain mesenchymal cells (namely hepatic stellate cells and stellate cell-derived myofibroblasts) undergo mesenchymal-to-epithelial transition (MET), revert to epithelial cells, and ultimately differentiate into either hepatocytes or cholangiocytes. Although this theory is highly controversial, it suggests that the balance between EMT and MET modulates the outcome of liver injury. This review summarizes recent advances that support or refute the concept that certain types of liver cells are capable of phenotype transition (i.e., EMT and MET) during both culture conditions and chronic liver injury.

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