scholarly journals Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition

2012 ◽  
Author(s):  
Christian Gespach
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast Cancer Cell ◽  
Genetic Models ◽  
Invasive Growth ◽  
Human Breast ◽  
Mesenchymal Transition

Ribosome Incorporation Induces EMT-like Phenomenon with Cell Cycle Arrest in Human Breast Cancer Cell

2021 ◽  
pp. 1-10
Author(s):  
Mikiko Kudo ◽  
Mohammad Badrul Anam ◽  
Arif Istiaq ◽  
Shah Adil Ishtiyaq Ahmad ◽  
Naofumi Ito ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Dermal Fibroblasts ◽  
Human Breast ◽  
Mesenchymal Transition ◽  
Cell Clusters

Although ribosomes are generally known to be a translational machinery, some ribosomal proteins also have accessory functions involving early development and differentiation. Previously, we reported that ribosome incorporation into human dermal fibroblasts generated embryoid body-like cell clusters, altered cellular fate, and differentiated into cells of all 3 germ layers. However, the molecular phenomena induced by ribosome incorporation in the cell remained unknown. Here, we demonstrate that ribosome incorporation into human breast cancer cell MCF7 leads to ribosome-induced cell clusters (RICs) formation accompanying with epithelial-mesenchymal transition (EMT)-like gene expression. Following ribosome incorporation, MCF7 cells cease proliferation, which is caused by inhibition of cell cycle transition from G0 to G1 phase. Further, MCF7 RICs show induced expression of EMT markers, TGF-β1 and Snail along with autophagy markers and tumor suppressor gene p53. These findings indicate that the incorporation of ribosome into cancer cells induces an EMT-like phenomenon and changes the cancer cell characteristics.

scholarly journals Raloxifene Inhibits Estrogen-induced Up-regulation of Telomerase Activity in a Human Breast Cancer Cell Line

2003 ◽  
Vol 278 (44) ◽  
pp. 43363-43372 ◽  
Author(s):  
Jun Kawagoe ◽  
Masahide Ohmichi ◽  
Toshifumi Takahashi ◽  
Chika Ohshima ◽  
Seiji Mabuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Telomerase Activity ◽  
Human Breast Cancer Cell ◽  
Human Breast

Human breast cancer cell enrichment by Dean flow driven microfluidic channels

2015 ◽  
Vol 22 (3) ◽  
pp. 645-652 ◽  
Author(s):  
M. Zuvin ◽  
N. Mansur ◽  
S. Z. Birol ◽  
L. Trabzon ◽  
A. Sayı Yazgan
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Microfluidic Channels ◽  
Human Breast ◽  
Dean Flow ◽  
Cell Enrichment
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