scholarly journals Prognostic and diagnostic relevance of hypermethylated in cancer 1 (HIC1) CpG island methylation in renal cell carcinoma

2012 ◽  
Author(s):  
M. Kuczyk
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cpg Island ◽  
Cpg Island Methylation

scholarly journals Prognostic significance of promoter CpG island methylation of obesity-related genes in patients with nonmetastatic renal cell carcinoma

Cancer ◽  
2017 ◽  
Vol 123 (18) ◽  
pp. 3617-3627 ◽  
Author(s):  
Julia Mendoza-Pérez ◽  
Jian Gu ◽  
Luis A. Herrera ◽  
Nizar M. Tannir ◽  
Shanyu Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cpg Island ◽  
Prognostic Significance ◽  
Cpg Island Methylation

scholarly journals Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma

Epigenetics ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. 278-290 ◽  
Author(s):  
Christopher J. Ricketts ◽  
Mark R. Morris ◽  
Dean Gentle ◽  
Michael Brown ◽  
Naomi Wake ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cpg Island ◽  
Methylation Analysis ◽  
Novel Genes ◽  
Genome Wide ◽  
Cpg Island Methylation

scholarly journals Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma

2010 ◽  
Vol 176 (2) ◽  
pp. 575-584 ◽  
Author(s):  
Iris J.H. van Vlodrop ◽  
Marcella M.L. Baldewijns ◽  
Kim M. Smits ◽  
Leo J. Schouten ◽  
Leander van Neste ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cpg Island ◽  
Prognostic Significance ◽  
Cell Renal Cell Carcinoma

CpG-island methylation of GATA-family members GATA3 and GATA5 in renal cell carcinoma and association with clinicopathological parameters and progression-free survival.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 370-370
Author(s):  
Inga Peters ◽  
Kai Gebauer ◽  
Faranaz Atschekzei ◽  
Joerg Hennenlotter ◽  
Mario W. Kramer ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cpg Island ◽  
Cell Cancer ◽  
Family Members ◽  
Progression Free Survival ◽  
Clinicopathological Parameters ◽  
Free Survival ◽  
Gata Family

370 Background: Transcriptional inactivation and CGI methylation of GATA3 and −5 has been reported to be involved in mammary carcinoma, pancreatic cancer, colorectal and gastric carcinogenesis. A recent study demonstrated that a loss of GATA-3 expression due to partially methylation silencing in several renal cell carcinoma (RCC) patients. We quantitatively investigated GATA3 and −5 CGI methylation in RCC and analyzed its association with clinical characteristics as well as progression free survival of patients. Methods: Methylation data were obtained from a quantitative methylation-specific polymerase chain reaction assay (QMSP) for both genes. We investigated 108 RCC and 77 paired tissue samples as well as six RCC cell lines. Statistical analyses were carried out using the paired t-test for matched tumor (TU) and adjacent normal (adN) samples, logistic regression for comparisons of independent samples and cox regression for survival analysis. Results: In paired samples we found a significant higher methylation in TU compared to adN for GATA3 (P=0.007) and for GATA5 (P=3.6*10−9) for all RCCs. GATA5 showed also strong correlations between methylation and status of metastasis (P=0.05) and advanced (pT≥3 and/or N+, M+) tumor samples compared to localized (pT≤2, N0, M0) tumors (P=4.7*10−9). A decreased progression free survival in cox proportional hazard model analysis could be demonstrated for patients with a high GATA5 methylation (P=0.0006, HR=6.5) and a trend could also be seen for GATA3 methylated patients (P=0.06). Conclusions: GATA3 and −5 were identified to demonstrate tumor-specific CGI hypermethylation in renal cell cancer patients. The association of GATA5 CGI methylation with metastasis, advanced disease and progression free survival of patients indicates that epigenetic alterations of both genes are involved in renal cell carcinogenesis. GATA5 methylation could serve as a biomarker for tumor progression. Further prospective and functional investigations are necessary to clarify whether CGI methylation of GATA family members can provide independent information for future clinical management of patients with RCC.

scholarly journals GATA5 CpG island hypermethylation is an independent predictor for poor clinical outcome in renal cell carcinoma

2014 ◽  
Vol 31 (4) ◽  
pp. 1523-1530 ◽  
Author(s):  
INGA PETERS ◽  
KAI GEBAUER ◽  
NATALIA DUBROWINSKAJA ◽  
FARANAZ ATSCHEKZEI ◽  
MARIO W. KRAMER ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Clinical Outcome ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Independent Predictor ◽  
Cpg Island ◽  
Poor Clinical Outcome

Association of CpG island methylator phenotype with clear-cell renal cell carcinoma aggressiveness.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 4574-4574 ◽  
Author(s):  
Gabriel Malouf ◽  
Jianping Zhang ◽  
Nizar M. Tannir ◽  
Erika Thompson ◽  
Jean-Philippe Spano ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Cell Renal Cell Carcinoma ◽  
Methylator Phenotype
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