scholarly journals Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression

2011 ◽  
Author(s):  
Atsushi Nakajima
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Leptin Receptor ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Long Form ◽  
Colorectal Cancer Progression

scholarly journals Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Hong-li Jiao ◽  
Bin-shu Weng ◽  
Shan-shan Yan ◽  
Zi-mo Lin ◽  
Shu-yang Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Ras Signaling ◽  
Invasion And Metastasis ◽  
In Vivo Models ◽  
Ras Signaling Pathway ◽  
Colorectal Cancer Progression

AbstractOxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the role of OSBPL3 in the proliferation, invasion and metastasis of CRC remains unclear. In this study, we investigated the role of OSBPL3 in CRC and found that its expression was significantly higher in CRC tissues than that in normal tissues. In addition, high expression of OSBPL3 was closely related to poor differentiation, advanced TNM stage and poor prognosis of CRC. Further experiments showed that over-expression of OSBPL3 promoted the proliferation, invasion and metastasis of CRC in vitro and in vivo models. Moreover, we revealed that OSBPL3 promoted CRC progression through activation of RAS signaling pathway. Furthermore, we demonstrated that hypoxia induced factor 1 (HIF-1A) can regulate the expression of OSBPL3 via binding to the hypoxia response element (HRE) in the promoter of OSBPL3. In summary, Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway. This novel mechanism provides a comprehensive understanding of both OSBPL3 and the RAS signaling pathway in the progression of CRC and indicates that the HIF1A–OSBPL3–RAS axis is a potential target for early therapeutic intervention in CRC progression.

scholarly journals TMEM100 Modulates TGF-β Signaling Pathway to Inhibit Colorectal Cancer Progression

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Huixia Li ◽  
Chuan Cheng ◽  
Weibo You ◽  
Jiujian Zheng ◽  
Jie Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Transmembrane Protein ◽  
Expression Data ◽  
Mrna Expression Data ◽  
Colorectal Cancer Progression ◽  
Inhibitor Gene

Objectives. This study investigated the functional mechanism of transmembrane protein 100 (TMEM100) as a tumor inhibitor gene in CRC cells and offered a reference for the treatment of CRC. Methods. The mRNA expression data of CRC were acquired from the TCGA database to mine differentially expressed mRNAs. The role of TMEM100 in the progression of CRC cells was evaluated by MTT, colony formation, scratch healing, and Transwell assays. The influence of TMEM100 on the TGF-β signaling pathway was detected by western blot. Results. TMEM100 was markedly lowly expressed in CRC. CRC cell growth was significantly suppressed by overexpressing TMEM100 but noticeably facilitated by silencing TMEM100. Overexpression of TMEM100 inhibited the activation of the TGF-β signaling pathway, thus inhibiting malignant progression of CRC. Conclusion. TMEM100 is lowly expressed in CRC, which can suppress CRC cell growth by regulating the TGF-β signaling pathway.

scholarly journals The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831770551 ◽  
Author(s):  
Mohammad Reza Sadeghi ◽  
Farhad Jeddi ◽  
Narges Soozangar ◽  
Mohammad Hossein Somi ◽  
Nasser Samadi
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Colorectal Cancer Progression

Abstract 3142: Stress regulated role of lncRNA Malat1 in colorectal cancer progression and metastasis

2020 ◽  
Author(s):  
Kyle Doxtater ◽  
Chidi Zacheaus ◽  
Radhika Sekhri ◽  
Utkarsh K. Mishra ◽  
Zachary E. Stiles ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Lncrna Malat1 ◽  
Colorectal Cancer Progression
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