Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients

2002 ◽  
Author(s):  
Lea Pylkkanen ◽  
Henrik Wolff ◽  
Tuula Stjernvall ◽  
Paivi Tuominen ◽  
Thanos Sioris ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Expression ◽  
Cancer Patients ◽  
Loss Of Heterozygosity ◽  
Fhit Gene ◽  
Lung Cancer Patients ◽  
Fhit Protein

scholarly journals P33.02 Comparison of PD-L1 Protein Expression Between Primary and Metastatic Lesions in Lung Cancer Patients

2021 ◽  
Vol 16 (3) ◽  
pp. S405-S406
Author(s):  
M. Moutafi ◽  
W. Tao ◽  
R. Huang ◽  
J. Haberberger ◽  
B. Alexander ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Expression ◽  
Cancer Patients ◽  
Lung Cancer Patients ◽  
Metastatic Lesions ◽  
L1 Protein

Prognostic Relevance of Altered pRb and p53 Protein Expression in Surgically Treated Non-Small Cell Lung Cancer Patients

Oncology ◽  
2004 ◽  
Vol 67 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Dorota Dworakowska ◽  
Ewa Jassem ◽  
Jacek Jassem ◽  
Klaus Hermann Wiedorn ◽  
Carsten Boltze ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Expression ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
P53 Protein ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
P53 Protein Expression

P-273 Loss of heterozygosity off the P16, P53 and APC gene in oral cavity exfoliate citologic material among lung cancer patients

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S186
Author(s):  
J. Sanz Ortega ◽  
J. Sanz Esponera ◽  
S. Hernandez ◽  
M. Saez ◽  
E. Roig ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Oral Cavity ◽  
Cancer Patients ◽  
Loss Of Heterozygosity ◽  
Apc Gene ◽  
Lung Cancer Patients

543 Analysis of FHIT gene alterations in primary tumours, bronchial mucosa biopsies and sputum specimens from lung cancer patients

Lung Cancer ◽  
1997 ◽  
Vol 18 ◽  
pp. 139
Author(s):  
Silvana Tornielli ◽  
Cathy Ratcliffe ◽  
Laura Sard ◽  
Katia Musso ◽  
Elda Tagliabue ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Bronchial Mucosa ◽  
Fhit Gene ◽  
Lung Cancer Patients ◽  
Gene Alterations

Decreased Fragile Histidine Triad Gene Protein Expression Is Associated With Worse Prognosis in Oral Squamous Carcinoma

2006 ◽  
Vol 130 (2) ◽  
pp. 158-164
Author(s):  
Leana A. Guerin ◽  
Henry T. Hoffman ◽  
M. Bridget Zimmerman ◽  
Robert A. Robinson
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Fhit Gene ◽  
Fragile Histidine Triad ◽  
Fhit Protein

Abstract Context.—Fragile histidine triad (FHIT) gene is thought to be a tumor suppressor; abnormalities in expression have been reported in a variety of neoplasms. Objective.—To determine whether abnormalities of FHIT protein expression or loss of heterozygosity in the FHIT gene were correlated with survival or other clinical parameters in patients with oral cavity squamous cell carcinoma. Design.—Fifty-three patients with initial surgical treatment of oral cavity squamous cell carcinoma were followed a minimum of 5 years or until death. The FHIT protein expression was studied by immunohistochemistry in all patients, and a subset of 20 patients was studied for allelic loss of heterozygosity and microsatellite instability using formalin-fixed, paraffin-embedded tissue. Results.—Sixty-one percent of patients whose tumors had reduced FHIT expression were dead of disease, and 37% of patients whose tumors exhibited preserved FHIT expression were dead of disease at 5-year follow-up. Log-rank analysis showed that patients retaining FHIT expression had a longer overall survival (P = .03) and disease-free survival (P = .01). The FHIT expression was not correlated with node status or clinical stage. Loss of heterozygosity was seen in 10 (50%) of 20 tumors, low levels of microsatellite instability in 4 (20%) of 20 tumors, and high levels of microsatellite instability in 1 (5%) of 20 tumors tested. Conclusions.—The FHIT gene was associated with a worse survival outcome when its expression was reduced in patients with oral cavity squamous cell carcinoma. Loss of heterozygosity in the gene was common, but no correlation with protein expression was found. Neither loss of heterozygosity nor microsatellite instability was found to correlate with survival. Because genomic alterations involving loss of heterozygosity of the FHIT gene were not associated with protein expression in these tumors, the presence or absence of FHIT expression may be controlled by other factors.

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