PROSTATE-CANCER SURVEILLANCE - A COST-EFFECTIVE STRATEGY

1993 ◽  
Author(s):  
DV SCHAPIRA ◽  
AR JARRETT
Keyword(s):  
Prostate Cancer ◽  
Cost Effective ◽  
Cancer Surveillance ◽  
Effective Strategy ◽  
Cost Effective Strategy

scholarly journals Detecting Germline PTEN Mutations Among At-Risk Patients With Cancer: An Age- and Sex-Specific Cost-Effectiveness Analysis

2015 ◽  
Vol 33 (23) ◽  
pp. 2537-2544 ◽  
Author(s):  
Joanne Ngeow ◽  
Chang Liu ◽  
Ke Zhou ◽  
Kevin D. Frick ◽  
David B. Matchar ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cleveland Clinic ◽  
Cost Effective ◽  
Cancer Surveillance ◽  
Sensitivity Analyses ◽  
Base Case ◽  
Effective Strategy ◽  
Female Patients ◽  
Cost Effective Strategy ◽  
The Cost

Purpose Cowden syndrome (CS) is an autosomal dominant disorder characterized by benign and malignant tumors. One-quarter of patients who are diagnosed with CS have pathogenic germline PTEN mutations, which increase the risk of the development of breast, thyroid, uterine, renal, and other cancers. PTEN testing and regular, intensive cancer surveillance allow for early detection and treatment of these cancers for mutation-positive patients and their relatives. Individual CS-related features, however, occur commonly in the general population, making it challenging for clinicians to identify CS-like patients to offer PTEN testing. Patients and Methods We calculated the cost per mutation detected and analyzed the cost-effectiveness of performing selected PTEN testing among CS-like patients using a semi-quantitative score (the PTEN Cleveland Clinic [CC] score) compared with existing diagnostic criteria. In our model, first-degree relatives of the patients with detected PTEN mutations are offered PTEN testing. All individuals with detected PTEN mutations are offered cancer surveillance. Results CC score at a threshold of 15 (CC15) costs from $3,720 to $4,573 to detect one PTEN mutation, which is the most inexpensive among the different strategies. At base-case, CC10 is the most cost-effective strategy for female patients who are younger than 40 years, and CC15 is the most cost-effective strategy for female patients who are between 40 and 60 years of age and male patients of all ages. In sensitivity analyses, CC15 is robustly the most cost-effective strategy for probands who are younger than 60 years. Conclusion Use of the CC score as a clinical risk calculator is a cost-effective prescreening method to identify CS-like patients for PTEN germline testing.

A cost effective strategy to fabricate STA@PF@Cu2O hierarchical structure on wood surface: aimed at superhydrophobic modification

2021 ◽  
Vol 55 (2) ◽  
pp. 565-583
Author(s):  
Ke Zhan ◽  
Quanxiong Lu ◽  
Sengwei Xia ◽  
Congnan Guo ◽  
Sisi Zhao ◽  
...  
Keyword(s):  
Hierarchical Structure ◽  
Wood Surface ◽  
Cost Effective ◽  
Effective Strategy ◽  
Cost Effective Strategy

A cost effective strategy for managing GI bleeding secondary to peptic ulcer disease

1995 ◽  
Vol 108 (4) ◽  
pp. A18 ◽  
Author(s):  
I Hussain ◽  
WH Farrar ◽  
EJ Sofian ◽  
TF Bader ◽  
JD Strom ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Cost Effective ◽  
Effective Strategy ◽  
Gi Bleeding ◽  
Ulcer Disease ◽  
Cost Effective Strategy

scholarly journals Scaling-Up the Recognition of Indigenous and Community Land Rights: Opportunities, Costs and Climate Implications

2021 ◽  
Author(s):  
◽  
Keyword(s):  
Indigenous Peoples ◽  
Cost Effective ◽  
Land Rights ◽  
Scaling Up ◽  
Local Communities ◽  
Effective Strategy ◽  
Cost Effective Strategy ◽  
International Funding ◽  
Growing Body ◽  
Alternative Solutions

A growing body of evidence suggests that recognition of the collective tenure rights of Indigenous Peoples, local communities, and Afro-descendants is a powerful and cost-effective strategy for addressing the climate and biodiversity crises. In spite of this, international funding for rights recognition pales in comparison to donor mobilization around alternative solutions to these crises.

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