Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice

2001 ◽  
Author(s):  
Francesco D'Agostini ◽  
Roumen Balansky ◽  
Carlo Bennicelli ◽  
Ronald Lubet ◽  
Gary Kelloff ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Lung Tumor ◽  
Pilot Studies ◽  
Tumor Yield

scholarly journals Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

2014 ◽  
Vol 7 (2) ◽  
pp. 73-84 ◽  
Author(s):  
Karsta Luettich ◽  
Yang Xiang ◽  
Anita Iskandar ◽  
Alain Sewer ◽  
Florian Martin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Cigarette Smoke ◽  
Lung Tumor ◽  
Immune Surveillance ◽  
Gene Expression Signature ◽  
Chemical Carcinogenesis ◽  
Lung Tumors ◽  
Whole Body ◽  
Significant Differential Expression

ABSTRACT The A/J mouse is highly susceptible to lung tumor induction and has been widely used as a screening model in carcinogenicity testing and chemoprevention studies. However, the A/J mouse model has several disadvantages. Most notably, it develops lung tumors spontaneously. Moreover, there is a considerable gap in our understanding of the underlying mechanisms of pulmonary chemical carcinogenesis in the A/J mouse. Therefore, we examined the differences between spontaneous and cigarette smokerelated lung tumors in the A/J mouse model using mRNA and microRNA (miRNA) profiling. Male A/J mice were exposed whole-body to mainstream cigarette smoke (MS) for 18 months. Gene expression interaction term analysis of lung tumors and surrounding nontumorous parenchyma samples from animals that were exposed to either 300 mg/m3 MS or sham-exposed to fresh air indicated significant differential expression of 296 genes. Ingenuity Pathway Analysis® (IPA®) indicated an overall suppression of the humoral immune response, which was accompanied by a disruption of sphingolipid and glycosaminoglycan metabolism and a deregulation of potentially oncogenic miRNA in tumors of MS-exposed A/J mice. Thus, we propose that MS exposure leads to severe perturbations in pathways essential for tumor recognition by the immune system, thereby potentiating the ability of tumor cells to escape from immune surveillance. Further, exposure to MS appeared to affect expression of miRNA, which have previously been implicated in carcinogenesis and are thought to contribute to tumor progression. Finally, we identified a 50-gene expression signature and show its utility in distinguishing between cigarette smoke-related and spontaneous lung tumors

scholarly journals Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke

2012 ◽  
Vol 131 (9) ◽  
pp. 1991-1997 ◽  
Author(s):  
Roumen Balansky ◽  
Gancho Ganchev ◽  
Marietta Iltcheva ◽  
Maria Kratchanova ◽  
Petko Denev ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Lung Tumor ◽  
Tumor Development ◽  
Berry Extracts

Lung Tumor Resection Ups Melanoma Survival

2007 ◽  
Vol 38 (7) ◽  
pp. 46
Author(s):  
ALICIA AULT
Keyword(s):  
Lung Tumor ◽  
Tumor Resection

Offender-nightmares: Two pilot studies.

Dreaming ◽  
2018 ◽  
Vol 28 (2) ◽  
pp. 140-149
Author(s):  
Jonas Mathes ◽  
Monika Renvert ◽  
Christian Eichhorn ◽  
Simon Freiherr von Martial ◽  
Annika Gieselmann ◽  
...  
Keyword(s):  
Pilot Studies

The Maastricht Cohort Study on Fatigue and Psychological Distress at Work: Pilot Studies of the Questionnaire

1999 ◽  
Author(s):  
Ute Bultmann ◽  
Anna J. H. M. Beurskens ◽  
IJmert Kant ◽  
Gerard M. H. Swaen
Keyword(s):  
Cohort Study ◽  
Psychological Distress ◽  
Pilot Studies

Job content questionnaire 2.0: Results of multi-country pilot studies and final new scale decisions

2013 ◽  
Author(s):  
R. Karasek ◽  
W. Agbenyikey ◽  
M. Dollard ◽  
M. Formazin ◽  
J. Li ◽  
...  
Keyword(s):  
Pilot Studies ◽  
Job Content Questionnaire ◽  
Job Content
Sign in / Sign up

Export Citation Format

Share Document