scholarly journals Self-renewal molecular mechanisms of colorectal cancer stem cells

2016 ◽  
Vol 39 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Tianhui Pan ◽  
Jinghong Xu ◽  
Yongliang Zhu
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Molecular Mechanisms ◽  
Self Renewal ◽  
Colorectal Cancer Stem Cells

scholarly journals Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Yapeng Ji ◽  
Chuanzhen Yang ◽  
Zefang Tang ◽  
Yongfeng Yang ◽  
Yonglu Tian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Adenylate Kinase ◽  
Drug Target ◽  
Therapeutic Strategy ◽  
Metabolic Reprogramming ◽  
Self Renewal ◽  
Colorectal Cancer Stem Cells ◽  
Metabolic Advantage

Abstract Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is an innovative therapeutic strategy for colorectal cancer (CRC) patients with poor prognosis and relapse. However, the context-dependent metabolic traits of CRCSCs remain poorly elucidated. Here we report that adenylate kinase hCINAP is overexpressed in CRC tissues. Depletion of hCINAP inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs with a loss of mesenchymal signature. Mechanistically, hCINAP binds to the C-terminal domain of LDHA, the key regulator of glycolysis, and depends on its adenylate kinase activity to promote LDHA phosphorylation at tyrosine 10, resulting in the hyperactive Warburg effect and the lower cellular ROS level and conferring metabolic advantage to CRCSC invasion. Moreover, hCINAP expression is positively correlated with the level of Y10-phosphorylated LDHA in CRC patients. This study identifies hCINAP as a potent modulator of metabolic reprogramming in CRCSCs and a promising drug target for CRC invasion and metastasis.

MicroRNA-451 Is Involved in the Self-renewal, Tumorigenicity, and Chemoresistance of Colorectal Cancer Stem Cells

Stem Cells ◽  
2011 ◽  
Vol 29 (11) ◽  
pp. 1661-1671 ◽  
Author(s):  
Nerea Bitarte ◽  
Eva Bandres ◽  
Valentina Boni ◽  
Ruth Zarate ◽  
Javier Rodriguez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
The Self ◽  
Self Renewal ◽  
Colorectal Cancer Stem Cells

scholarly journals The microRNA-210-Stathmin1 Axis Decreases Cell Stiffness to Facilitate the Invasiveness of Colorectal Cancer Stem Cells

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1833
Author(s):  
Tsai-Tsen Liao ◽  
Wei-Chung Cheng ◽  
Chih-Yung Yang ◽  
Yin-Quan Chen ◽  
Shu-Han Su ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Motility ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Cell Stiffness ◽  
Mesenchymal Transition ◽  
Cytoskeletal Dynamics ◽  
Colorectal Cancer Stem Cells

Cell migration is critical for regional dissemination and distal metastasis of cancer cells, which remain the major causes of poor prognosis and death in patients with colorectal cancer (CRC). Although cytoskeletal dynamics and cellular deformability contribute to the migration of cancer cells and metastasis, the mechanisms governing the migratory ability of cancer stem cells (CSCs), a nongenetic source of tumor heterogeneity, are unclear. Here, we expanded colorectal CSCs (CRCSCs) as colonospheres and showed that CRCSCs exhibited higher cell motility in transwell migration assays and 3D invasion assays and greater deformability in particle tracking microrheology than did their parental CRC cells. Mechanistically, in CRCSCs, microRNA-210-3p (miR-210) targeted stathmin1 (STMN1), which is known for inducing microtubule destabilization, to decrease cell elasticity in order to facilitate cell motility without affecting the epithelial–mesenchymal transition (EMT) status. Clinically, the miR-210-STMN1 axis was activated in CRC patients with liver metastasis and correlated with a worse clinical outcome. This study elucidates a miRNA-oriented mechanism regulating the deformability of CRCSCs beyond the EMT process.

PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer

2021 ◽  
Author(s):  
Yingru Zhang ◽  
Chunpu Li ◽  
Ru Jia ◽  
Ruixuan Gao ◽  
Yiyang Zhao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Amino Acid ◽  
Cancer Stem Cells ◽  
Drug Release ◽  
Signaling Pathway ◽  
Water Solubility ◽  
Sustained Drug Release ◽  
Colorectal Cancer Stem Cells ◽  
Micelle System

A new nano-micelle system with better water solubility and sustained drug release effect, targeting colorectal cancer stem cells, effectively inhibits the growth and metastasis of colorectal cancer via the Wnt/β-catenin signaling pathway.

Brg1 is required to maintain colorectal cancer stem cells

2021 ◽  
Author(s):  
Takaaki Yoshikawa ◽  
Akihisa Fukuda ◽  
Mayuki Omatsu ◽  
Mio Namikawa ◽  
Makoto Sono ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Colorectal Cancer Stem Cells
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