scholarly journals The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain

2016 ◽  
Vol 38 (5) ◽  
pp. 1433-1442 ◽  
Author(s):  
Chi-Hua Guo ◽  
Lu Bai ◽  
Huang-Hui Wu ◽  
Jing Yang ◽  
Guo-Hong Cai ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
Bone Cancer ◽  
Bone Cancer Pain

Blocking EphB1 Receptor Forward Signaling in Spinal Cord Relieves Bone Cancer Pain and Rescues Analgesic Effect of Morphine Treatment in Rodents

2011 ◽  
Vol 71 (13) ◽  
pp. 4392-4402 ◽  
Author(s):  
Su Liu ◽  
Wen-Tao Liu ◽  
Yue-Peng Liu ◽  
Hai-Long Dong ◽  
Mark Henkemeyer ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Analgesic Effect ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Morphine Treatment

scholarly journals Analgesic effect and possible mechanism of SCH772984 intrathecal injection on rats with bone cancer pain

2016 ◽  
Vol 24 (3) ◽  
pp. 354-362 ◽  
Author(s):  
Juhua Bian ◽  
Shanshan Zhu ◽  
Wenwen Ma ◽  
Chunwei Li ◽  
Muhammad Aqeel Ashraf
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
Intrathecal Injection ◽  
Bone Cancer ◽  
Bone Cancer Pain

144. Analgesic Effect of Crotalphine in a New Model of Rat Bone Cancer Pain

Toxicon ◽  
2012 ◽  
Vol 60 (2) ◽  
pp. 168-169
Author(s):  
Yara Cury ◽  
Vanessa P. Gutierrez ◽  
Patricia Brigatte ◽  
Vanessa O. Zambelli ◽  
Gisele Picolo ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
New Model ◽  
Rat Bone

scholarly journals Activation of the P2X7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats

2018 ◽  
Vol 14 ◽  
pp. 174480691880303 ◽  
Author(s):  
Pengtao Li ◽  
Quan Zhang ◽  
Zhi Xiao ◽  
Shouyang Yu ◽  
Yan Yan ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
P2x7 Receptor ◽  
Bone Cancer ◽  
Periaqueductal Gray ◽  
Bone Cancer Pain

scholarly journals Baicalin Ameliorates Bone Cancer Pain by Suppressing TRPV1 in Rat Dorsal Root Ganglia

2020 ◽  
Vol 15 (1) ◽  
pp. 1934578X1989956 ◽  
Author(s):  
Ping Li ◽  
Ying Bi ◽  
Yuchun Deng ◽  
Donglin Xiong ◽  
Anxue Li
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
Dorsal Root ◽  
Transient Receptor Potential ◽  
Bone Cancer ◽  
Receptor Potential ◽  
Bone Cancer Pain ◽  
Flavonoid Compound ◽  
Transient Receptor

Bone cancer pain is characterized by moderate to severe ongoing pain that commonly requires the use of opiates, which could produce tolerance or addiction. Baicalin is a flavonoid compound extracted from Huang Qin, possesses antioxidant properties, and has an analgesic effect on nitroglycerin-induced migraine in rats and neuropathic pain in spinal nerve ligation rats. However, the effect of baicalin on bone cancer pain is still unclear. Therefore, the aim of this study is to examine the analgesic effect of baicalin in a rat model of bone cancer pain. Bone cancer pain animal model was created by tumor cell implantation (TCI). Animal behaviors were measured using a set of mechanical or electronic von Frey apparatus and hot plate. mRNA expression and inflammation cytokine levels were examined by Quantitative polymerase chain reaction (qPCR) and enzyme linked immunosorbent assay (ELISA) methods. Baicalin suppressed the upregulation of transient receptor potential vanilloid 1 (TRPV1), but not transient receptor potential A1 in dorsal root ganglion (DRG) of TCI rats. In addition, the phosphorylation of extracellular regulated protein kinases (ERK) was also suppressed by baicalin injection in DRG of TCI rats. Our results revealed that baicalin might play a promising analgesic role by preventing the upregulation of TRPV1 in DRG of TCI rats. Baicalin administration prevented the progress of bone cancer pain and reduced mechanical allodynia and thermal hyperalgesia. Our study clearly established a novel role of baicalin as an analgesic agent for bone cancer pain. And the analgesic role of baicalin in bone cancer pain might involve a TRPV1.

scholarly journals Analgesic Effect of Intrathecal Ginsenosides in a Murine Bone Cancer Pain

2010 ◽  
Vol 23 (4) ◽  
pp. 230 ◽  
Author(s):  
Myung Ha Yoon ◽  
Woong Mo Kim ◽  
Hyung Gon Lee ◽  
Jeong Il Choi ◽  
Yeo Ok Kim ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Analgesic Effect ◽  
Bone Cancer ◽  
Bone Cancer Pain
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