scholarly journals Rosa hybrida extract suppresses vascular smooth muscle cell responses by the targeting of signaling pathways, cell cycle regulation and matrix metalloproteinase-9 expression

2016 ◽  
Vol 37 (4) ◽  
pp. 1119-1126 ◽  
Author(s):  
SE-JUNG LEE ◽  
SE YEON WON ◽  
SUNG LYEA PARK ◽  
JUN-HUI SONG ◽  
DAE-HWA NOH ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Signaling Pathways ◽  
Cell Cycle Regulation ◽  
Cell Responses ◽  
Cycle Regulation ◽  
Metalloproteinase 9

scholarly journals Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF-αStimulation

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Eun Sik Choi ◽  
Jung Joo Yoon ◽  
Byung Hyuk Han ◽  
Da Hye Jeong ◽  
Hye Yoom Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Cell Cycle Regulation ◽  
Muscle Cells ◽  
Antiproliferative Effects ◽  
And Migration ◽  
Cycle Regulation

Samul-Tang (SMT), consisting of four medicinal herbs, is a well-known herbal prescription treating hematological disorders related symptoms. Our previous study demonstrated that SMT attenuated inflammation of vascular endothelial cells. In condition of retained vascular dysfunction, vascular inflammation is initiated and results in activation of smooth muscle cells (SMCs). Activated SMCs lose control of cell cycle regulation and migrate into intima, resulting in formation of atheroma. Here, we further investigated whether SMT suppresses proliferation and migration of SMCs. SMT showed antiproliferative effects on SMCs by suppressing [3H]-thymidine incorporation against TNF-αstimulation. Underlying mechanisms of antiproliferative effects were found to be resulting from cell cycle regulation. SMT downregulated expression of cyclin D1-CDK4 and cyclin E-CDK2 complexes and upregulatedp21waf1/cip1andp27kip1. SMT also suppressed migration of SMCs against TNF-αstimulation. This is thought to have resulted from suppressing MMP2 and MMP9 expressions and ROS production. In summary, SMT attenuates abnormal migration of vascular smooth muscle cells via regulating cell cycle and suppressing MMPs expression and ROS production. Our study suggests that SMT, a traditionally used herbal formula, protects vascular smooth muscle cells and might be used as an antiatherosclerotic drug.

scholarly journals Different Cell Cycle Regulation of Vascular Smooth Muscle in Genetic Hypertension

Hypertension ◽  
2003 ◽  
Vol 42 (2) ◽  
pp. 184-188 ◽  
Author(s):  
Felix C. Tanner ◽  
Helen Greutert ◽  
Christine Barandier ◽  
Karin Frischknecht ◽  
Thomas F. Lüscher
Keyword(s):  
Cell Cycle ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Cell Cycle Regulation ◽  
Genetic Hypertension ◽  
Cycle Regulation
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