scholarly journals Electro-acupuncture exerts beneficial effects against cerebral ischemia and promotes the proliferation of neural progenitor cells in the cortical peri-infarct area through the Wnt/β-catenin signaling pathway

2015 ◽  
Vol 36 (5) ◽  
pp. 1215-1222 ◽  
Author(s):  
BIN CHEN ◽  
JING TAO ◽  
YUKUN LIN ◽  
RUHUI LIN ◽  
WEILIN LIU ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Beneficial Effects ◽  
Infarct Area

Injection of neural progenitor cells improved learning and memory dysfunction after cerebral ischemia

2008 ◽  
Vol 211 (1) ◽  
pp. 194-202 ◽  
Author(s):  
Nobuyuki Mochizuki ◽  
Norio Takagi ◽  
Koji Kurokawa ◽  
Chika Onozato ◽  
Yoshiyuki Moriyama ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Progenitor Cells ◽  
Learning And Memory ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Memory Dysfunction ◽  
Improved Learning

Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells

Epigenomics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1143-1161 ◽  
Author(s):  
Deepika Kandilya ◽  
Silambarasan Maskomani ◽  
Sukanya Shyamasundar ◽  
Paul Anantharajah Tambyah ◽  
Chan Shiao Yng ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Zika Virus ◽  
Neural Progenitor Cells ◽  
Methylation Status ◽  
Neural Progenitor ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway ◽  
Human Neural Progenitor Cells

Aim: This study was aimed to understand if Zika virus (ZIKV) alters the DNA methylome of human neural progenitor cells (hNPCs). Materials & methods: Whole genome DNA methylation profiling was performed using human methylationEPIC array in control and ZIKV infected hNPCs. Results & conclusion: ZIKV infection altered the DNA methylation of several genes such as WWTR1 (TAZ) and RASSF1 of Hippo signaling pathway which regulates organ size during brain development, and decreased the expression of several centrosomal-related microcephaly genes, and genes involved in stemness and differentiation in human neural progenitor cells. Overall, ZIKV downregulated the Hippo signaling pathway genes which perturb the stemness and differentiation process in hNPCs, which could form the basis for ZIKV-induced microcephaly.

scholarly journals Intravenous injection of neural progenitor cells facilitates angiogenesis after cerebral ischemia

2012 ◽  
Vol 3 (2) ◽  
pp. 43-53 ◽  
Author(s):  
Yoshiyuki Moriyama ◽  
Norio Takagi ◽  
Kanae Hashimura ◽  
Chisa Itokawa ◽  
Kouichi Tanonaka
Keyword(s):  
Cerebral Ischemia ◽  
Progenitor Cells ◽  
Intravenous Injection ◽  
Neural Progenitor Cells ◽  
Neural Progenitor

Abstract 133: Transplantation Of Neurosphere-forming Stem Cells Into Circulating Blood Attenuates Acute Inflammatory Activation Of Both Brain And Spleen After Cerebrovascular Ischemic Injury.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Soon-Tae Lee ◽  
Kon Chu ◽  
Keun-Hwa Jung ◽  
Hee-Kwon Park ◽  
Jeong-Min Kim ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Progenitor Cells ◽  
Inflammatory Cytokines ◽  
Neural Progenitor Cells ◽  
Focal Cerebral Ischemia ◽  
Neural Progenitor ◽  
Control Group ◽  
Tissue Ischemia ◽  
Realtime Pcr ◽  
Inflammatory Activation

Background and Objectives: Transplantation of neural progenitor cells (NPCs) has been studied to achieve the regeneration of damaged brain in experimental stroke models. Tissue ischemia induces systemic inflammatory activation, especially in spleen. However, the interaction between NPCs and immune/inflammatory cells has not been studied in ischemia models. In this study, we investigated whether NPC can attenuate cerebral and systemic inflammatory activation in focal cerebral ischemia. Methods: Focal cerebral ischemia was induced by intraluminal thread occlusion of the middle cerebral artery for 60 minutes (c57/bl6 adult male mice), and mouse NPC from primary neurosphere (1 million cells) or vehicle (PBS, control group) was injected via tail veins with cerebral reperfusion. Inflammatory cytokines were evaluated with RealTime-PCR at 22 hrs, and the weights of each spleen and thymus were measured. Results: Cerebral ischemia induced progressive atrophies of spleen and thymus when measured at 22 hr and 96 hr after ischemia. Intravenous injection of NPC accelerated these lymphoid organ atrophies, and the weights of spleen and thymus were significantly lower in NPC-injected mice at 96 hr after the ischemia compared to the vehicle injected mice. RealTime-PCR analysis using ischemic hemispheres and spleens showed reduced expressions of inflammatory cytokines, including TNF-alpha, IL-6, MIP-2, IL-13, FoxP3, IL-1beta, and IP10 in NPC-injected brains and spleens at 22 hr after the ischemia. Transplanted NPCs were detected in systemic organs, and mostly in spleen. NPC-injected mice showed reduced infarct volume and neurologic deficits. Conclusion: Intravenous transplantation of primary neuro-sphere cells in cerebral ischemia attenuated systemic inflammatory activation, which suggests that the immunomodulating property of neural progenitor cells can be applicable for preventing harmful inflammations after the tissue ischemia.

Sevoflurane Inhibits Neurogenesis and the Wnt-Catenin Signaling Pathway in Mouse Neural Progenitor Cells

2013 ◽  
Vol 13 (9) ◽  
pp. 1446-1454 ◽  
Author(s):  
Y. Zhang ◽  
Y. Dong ◽  
H. Zheng ◽  
V. Shie ◽  
H. Wang ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Signaling Pathway ◽  
Neural Progenitor Cells ◽  
Neural Progenitor
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