scholarly journals PI3K/AKT/PTEN pathway as a target for Crohn’s disease therapy (Review)

2014 ◽  
Vol 35 (1) ◽  
pp. 10-16 ◽  
Author(s):  
NANA TOKUHIRA ◽  
YASUKO KITAGISHI ◽  
MIHO SUZUKI ◽  
AKARI MINAMI ◽  
ATSUKO NAKANISHI ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Therapy

scholarly journals Trends in Inflammatory Bowel Disease Therapy: A Meta-Analytic Approach

1995 ◽  
Vol 9 (7) ◽  
pp. 405-411 ◽  
Author(s):  
Gregory W Whiting ◽  
Joseph Lau ◽  
Bruce Kupelnick ◽  
Thomas C Chalmers
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Analytic Approach ◽  
Disease Therapy ◽  
The Matrix ◽  
Inflammatory Bowel ◽  
Acute Attacks ◽  
New Treatments

OBJECTIVE: To illustrate the current meta-analytic approach to extracting clinically useful information from the glut of randomized controlled trials (RCTs) of the treatment of acute attacks of Crohn's disease.PROCEDURE: Acceptable RCTs were classified in a matrical format so that the feasibility of a meta-analysis of each treatment could be quickly determined. Each potential inclusion was then photocopied after blinding the source and outcome to minimize bias by the investigators.RESULTS AND CONCLUSIONS: The search was started in 1990, when a previous meta-analysis was completed. Over 100 citations in MEDLINE contained 21 RCTs of the treatment of acute attacks of Crohn's disease, and 11 more were culled from the references of recent papers. The meta-analysis most indicated by the matrix was a comparison of several different immunosuppressive regimens with a placebo. The previously demonstrated statistical significance was confirmed and the point made that it is no longer justified to compare any new treatments with a placebo. Cumulative meta-analysis, the process of performing a new analysis every time a new trial is published, revealed the importance of employing both random and fixed effect models when heterogeneity of treatment results is appreciable, as in this case.

The European Panel on the Appropriateness of Crohn’s Disease Therapy

Digestion ◽  
2005 ◽  
Vol 71 (1) ◽  
pp. 6-7 ◽  
Author(s):  
Renzo Caprilli ◽  
Pierre Michetti
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Therapy

Drug Safety in Crohn’s Disease Therapy

Digestion ◽  
2007 ◽  
Vol 76 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Pascal Juillerat ◽  
Valérie Pittet ◽  
Christian Felley ◽  
Christian Mottet ◽  
Florian Froehlich ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Drug Safety ◽  
Disease Therapy

scholarly journals OP028 Gut specific regulatory T cells – a new frontier for Crohn's disease therapy

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S17-S17
Author(s):  
R. Goldberg ◽  
C. Scotta ◽  
D. Cooper ◽  
E. Eliraz ◽  
E. Nir ◽  
...  
Keyword(s):  
T Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Regulatory T Cells ◽  
Disease Therapy ◽  
New Frontier
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