scholarly journals Autologous transplantation of adipose-derived mesenchymal stem cells attenuates cerebral ischemia and reperfusion injury through suppressing apoptosis and inducible nitric oxide synthase

2012 ◽  
Author(s):  
Dehua Li
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cerebral Ischemia ◽  
Autologous Transplantation ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Cerebral Ischemia And Reperfusion ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70

2004 ◽  
Vol 97 (2) ◽  
pp. 564-569 ◽  
Author(s):  
Juliann G. Kiang ◽  
Phillip D. Bowman ◽  
Brian W. Wu ◽  
Nyasa Hampton ◽  
Andrew G. Kiang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Caffeic Acid Phenethyl Ester ◽  
Inos Expression ◽  
Ischemia And Reperfusion ◽  
Hsp 70 ◽  
Ischemia And Reperfusion Injury ◽  
Oxide Synthase ◽  
Related Proteins ◽  
Inducible Nitric Oxide

The aim of this study was to determine whether hemorrhage affects the levels of a variety of stress-related proteins and whether changes can be inhibited by drugs reported to provide protection from ischemia and reperfusion injury. Male Swiss Webster mice were subjected to a 40% hemorrhage without resuscitation. Western blot analysis indicated that c-Jun (an AP-1 protein), Kruppel-like factor 6 (KFL6), and inducible nitric oxide synthase (iNOS) were upregulated sequentially in that order. Pretreatment of mice with geldanamycin (GA) 16 h before hemorrhage effectively inhibited the expression of the proteins KLF6 and iNOS, whereas caffeic acid phenethyl ester did not. GA pretreatment increased inducible heat shock protein (HSP) 70 but not HSP90 in both sham and hemorrhagic tissues. The overexpressed inducible HSP70 formed complexes with KLF6 and iNOS. These results suggest that GA may be therapeutically useful for reducing hemorrhage-induced injury when used as a presurgical treatment or when added to resuscitation fluids.

scholarly journals Core and Penumbral Nitric Oxide Synthase Activity during Cerebral Ischemia and Reperfusion in the Rat Pup

1999 ◽  
Vol 46 (4) ◽  
pp. 390-390 ◽  
Author(s):  
Stephen Ashwal ◽  
Beatriz Tone ◽  
Hui Rou Tian ◽  
Daniel J Cole ◽  
Boleslaw H Liwnicz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cerebral Ischemia ◽  
Nitric Oxide Synthase ◽  
Ischemia And Reperfusion ◽  
Cerebral Ischemia And Reperfusion ◽  
Oxide Synthase ◽  
Rat Pup ◽  
Nitric Oxide Synthase Activity
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