scholarly journals Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line

2012 ◽  
Vol 30 (4) ◽  
pp. 889-895 ◽  
Author(s):  
WENNA LIANG ◽  
MUNAN LIN ◽  
XIHAI LI ◽  
CANDONG LI ◽  
BIZHENG GAO ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Bone Formation ◽  
Cell Line ◽  
Signal Transduction Pathway ◽  
Osteoblastic Cell ◽  
Transduction Pathway ◽  
Osteoblastic Cell Line ◽  
Human Osteoblastic Cell

scholarly journals Immunomodulatory Potential of Differently-Terminated Ultra-Small Silicon Carbide Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 573
Author(s):  
Tereza Bělinová ◽  
Iva Machová ◽  
David Beke ◽  
Anna Fučíková ◽  
Adam Gali ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Cell Line ◽  
Metabolic Activity ◽  
Immune Cell ◽  
Cellular Membrane ◽  
Osteoblastic Cell ◽  
Osteoblastic Cell Line ◽  
Human Osteoblastic Cell ◽  
Different Response ◽  
Small Nanoparticles

Ultra-small nanoparticles with sizes comparable to those of pores in the cellular membrane possess significant potential for application in the field of biomedicine. Silicon carbide ultra-small nanoparticles with varying surface termination were tested for the biological system represented by different human cells (using a human osteoblastic cell line as the reference system and a monocyte/macrophage cell line as immune cells). The three tested nanoparticle surface terminations resulted in the observation of different effects on cell metabolic activity. These effects were mostly noticeable in cases of monocytic cells, where each type of particle caused a completely different response (‘as-prepared’ particles, i.e., were highly cytotoxic, –OH terminated particles slightly increased the metabolic activity, while –NH2 terminated particles caused an almost doubled metabolic activity) after 24 h of incubation. Subsequently, the release of cytokines from such treated monocytes and their differentiation into activated cells was determined. The results revealed the potential modulation of immune cell behavior following stimulation with particular ultra-small nanoparticles, thus opening up new fields for novel silicon carbide nanoparticle biomedical applications.

scholarly journals Phase-independent Inhibition by Retinoic Acid of Mineralization Correlated with Loss of Tetranectin Expression in a Human Osteoblastic Cell Line.

2001 ◽  
Vol 26 (4) ◽  
pp. 227-233 ◽  
Author(s):  
Kousuke Iba ◽  
Hideki Chiba ◽  
Toshihiko Yamashita ◽  
Seiichi Ishii ◽  
Norimasa Sawada
Keyword(s):  
Retinoic Acid ◽  
Cell Line ◽  
Osteoblastic Cell ◽  
Osteoblastic Cell Line ◽  
Human Osteoblastic Cell

scholarly journals Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6

Blood ◽  
1992 ◽  
Vol 80 (9) ◽  
pp. 2298-2305 ◽  
Author(s):  
K Oritani ◽  
T Kaisho ◽  
K Nakajima ◽  
T Hirano
Keyword(s):  
Signal Transduction ◽  
Retinoic Acid ◽  
Cell Line ◽  
Interleukin 6 ◽  
Signal Transduction Pathway ◽  
Inhibitory Effect ◽  
Hematopoietic Cell ◽  
Transduction Pathway ◽  
Macrophage Differentiation ◽  
Hematopoietic Cell Line

Abstract We established a radiation-induced murine hematopoietic cell line, Y6, that could be induced to differentiate into macrophages by interleukin- 6 (IL-6). IL-6 also induced growth inhibition and apoptosis in Y6 cells. Retinoic acid (RA) inhibited such effects of IL-6 on Y6 cells. The inhibitory effect of RA on the effects of IL-6 was not caused by the downregulation of the IL-6 receptor, because RA neither affected the expression of IL-6 receptor mRNA nor the expression of IL-6 receptor molecule on the cell surface. Furthermore, RA did not inhibit the IL-6-induced expression of junB mRNA, indicating that the expression of functionally active IL-6 receptor and the signal transduction pathway activating the junB gene are not inhibited by RA. IL-6-induced macrophage differentiation of Y6 cells was preceded by the downregulation of the c-myc gene, which was also prevented by RA. Because the inhibitory effect of RA on Y6 cells was reversible and seemed not to require de novo protein synthesis, the RA receptor by itself might be directly involved in the inhibition of the IL-6 signal transduction pathway. The results indicated that the IL-6 signal transduction pathways leading to the induction of macrophage differentiation and junB gene expression can be dissected by RA.

Controlled adhesion and proliferation of a human osteoblastic cell line by tuning the nanoporosity of titania and silica coatings

2013 ◽  
Vol 1 (2) ◽  
pp. 186-189 ◽  
Author(s):  
Martín G. Bellino ◽  
Sebastian Golbert ◽  
Mauricio C. De Marzi ◽  
Galo J. A. A. Soler-Illia ◽  
Martín F. Desimone
Keyword(s):  
Cell Line ◽  
Osteoblastic Cell ◽  
Osteoblastic Cell Line ◽  
Silica Coatings ◽  
Human Osteoblastic Cell
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