scholarly journals Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells

2011 ◽  
Author(s):  
Maria Nagai
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Insulin Like Growth Factor ◽  
17Β Estradiol ◽  
Mcf 7

scholarly journals Alterations in Phosphoinositide Metabolism Associated with 17β-Estradiol and Growth Factor Treatment of MCF-7 Breast Cancer Cells

1988 ◽  
Vol 2 (2) ◽  
pp. 159-166 ◽  
Author(s):  
Carl E. Freter ◽  
Marc E. Lippman ◽  
Andrea Cheville ◽  
Sydelle Zinn ◽  
Edward P. Gelmann
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Phosphoinositide Metabolism ◽  
17Β Estradiol ◽  
Mcf 7 ◽  
Growth Factor Treatment

scholarly journals Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells.

1996 ◽  
Vol 10 (3) ◽  
pp. 286-297 ◽  
Author(s):  
M J Ellis ◽  
B A Leav ◽  
Z Yang ◽  
A Rasmussen ◽  
A Pearce ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Mcf 7

INSULIN-LIKE GROWTH FACTOR TYPE I AND INSULIN-LIKE GROWTH FACTOR TYPE II STIMULATE OESTRADIOL-17β HYDROXYSTEROID DEHYDROGENASE (REDUCTIVE) ACTIVITY IN BREAST CANCER CELLS

1991 ◽  
Vol 129 (2) ◽  
pp. R5-R8 ◽  
Author(s):  
Anita Singh ◽  
M.J. Reed
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Hydroxysteroid Dehydrogenase ◽  
Type I ◽  
Insulin Like Growth Factor ◽  
Igf I ◽  
Factor Type ◽  
Mcf 7

ABSTRACT Oestradiol-17β hydroxysteroid dehydrogenase (E2DH) is present in normal and malignant breast tissues and also in cultured breast cancer cells. It can act in a reductive direction to convert oestrone to the biologically active oestrogen, oestradiol, or in an oxidative direction to metabolize oestradiol to oestrone and may therefore have a crucial role in regulating breast tissue concentrations of oestradiol. Insulin-like growth factor-type I (IGF-I) and IGF-II are both mitogens for breast cancer cells. In this study we have examined the effect of these growth factors on the reductive and oxidative activities of E2DH in MCF-7 (receptor positive) and MDA-MB-231 (receptor negative) breast cancer cells. Both IGF-I (80 ng/ml) and IGF-II (80 ng/ml) significantly stimulated E2DH reductive activity (up to 138%) in MCF-7 cells but had no effect on oxidative activity. Addition of IGF-II (100 ng/ml) to MDA-MB-231 cells resulted in a small but statistically significant (p<0.05) increase in E2DH reductive activity (18%) but in these cells reductive activity is 25-70 times lower than oxidative activity. If IGF-I and IGF-II act to stimulate E2DH reductive activity in breast tumours then such a mechanism could account for the increased concentrations of oestradiol detected in breast tumours.

Inducible Expression of Dominant Negative Insulin-like Growth Factor I Receptor in MCF-7 Breast Cancer Cells

Endocrine ◽  
2003 ◽  
Vol 22 (3) ◽  
pp. 293-304 ◽  
Author(s):  
Geetanjalee Modha ◽  
Anne Blanchard ◽  
Janine Sidorchuk ◽  
Marcello Venditti ◽  
Robert Shiu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Inducible Expression ◽  
Dominant Negative ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
Mcf 7
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