scholarly journals Oncostatin M promotes proliferation of ovarian cancer cells through signal transducer and activator of transcription 3

2011 ◽  
Author(s):  
Ying Yue
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Oncostatin M ◽  
Ovarian Cancer Cells ◽  
Signal Transducer ◽  
Transcription 3

scholarly journals Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3

2009 ◽  
Vol 125 (9) ◽  
pp. 2198-2204 ◽  
Author(s):  
Karuppaiyah Selvendiran ◽  
Anna Bratasz ◽  
M. Lakshmi Kuppusamy ◽  
Mia F. Tazi ◽  
Brian K. Rivera ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Signal Transducer ◽  
Transcription 3

scholarly journals Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells

2020 ◽  
Vol 21 (20) ◽  
pp. 7530
Author(s):  
Shakya Rajina ◽  
Woo Jean Kim ◽  
Jung-Hyun Shim ◽  
Kyung-Soo Chun ◽  
Sang Hoon Joo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Death ◽  
Molecular Mechanisms ◽  
Ovarian Cancer Cells ◽  
Signal Transducer ◽  
Antitumor Activities ◽  
Mitochondrial Superoxide ◽  
Dependent Cell ◽  
Transcription 3 ◽  
Cell Proportion

The mortality rate of ovarian cancer (OC) worldwide increases with age. OC is an often fatal cancer with a curative rate of only 20–30%, as symptoms often appear after disease progression. Studies have reported that isolinderalactone (ILL), a furanosesquiterpene derivative extracted from the dried root of Lindera aggregata, can inhibit several cancer cell lines’ growth. However, the molecular mechanisms underlying ILL activities in human OC cells remain unexplored. This study investigated the antitumor activities of ILL in human OC cells by inducing mitochondrial superoxide (mtSO) and JAK-signal transducer and activator of transcription 3 (STAT3)-dependent cell death. ILL caused cell death in SKOV-3 and OVCAR-3 cells and increased the cell proportion in the subG1 phase. Additionally, ILL significantly induced mtSO production and reduced ROS production. Moreover, ILL downregulated mitochondrial membrane potential and the expression levels of anti-apoptotic Bcl-2 family proteins and superoxide dismutase (SOD)2. Results showed that ILL decreased phosphorylation of serine 727 and tyrosine 705 of STAT3 and expression of survivin, a STAT3-regulated gene. Furthermore, ILL-induced cell death was reversed by pretreatment of Mito-TEMPO, a mitochondria-specific antioxidant. These results suggest that ILL induces cell death by upregulation of mtSO, downregulation of mitochondrial SOD2, and inactivation of the STAT3-mediated pathway.

Cytotoxic effects of disulfiram and synergism with cisplatin on ovarian cancer cells in vitro

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Cytotoxic Effects
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