scholarly journals Cimetidine inhibits the adhesion of gastric cancer cells expressing high levels of sialyl Lewis x in human vascular endothelial cells by blocking E-selectin expression

2011 ◽  
Vol 27 (4) ◽  
Author(s):  
Li
Keyword(s):  
Gastric Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Vascular Endothelial Cells ◽  
Sialyl Lewis X ◽  
Vascular Endothelial ◽  
Gastric Cancer Cells ◽  
Lewis X ◽  
Sialyl Lewis

scholarly journals Interactions of antitumour Sialyl Lewis X liposomes with vascular endothelial cells

2015 ◽  
Vol 1848 (5) ◽  
pp. 1099-1110 ◽  
Author(s):  
Anna Alekseeva ◽  
Marina Kapkaeva ◽  
Olga Shcheglovitova ◽  
Ivan Boldyrev ◽  
Galina Pazynina ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Sialyl Lewis X ◽  
Vascular Endothelial ◽  
Lewis X ◽  
Sialyl Lewis

Sulfated Sialyl Lewis X, the Putative L-Selectin Ligand, Detected on Endothelial Cells of High Endothelial Venules by a Distinct Set of Anti-Sialyl Lewis X Antibodies

1997 ◽  
Vol 230 (3) ◽  
pp. 546-551 ◽  
Author(s):  
Chikako Mitsuoka ◽  
Naoko Kawakami-Kimura ◽  
Mikiko Kasugai-Sawada ◽  
Nozomu Hiraiwa ◽  
Ken'ichi Toda ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Sialyl Lewis X ◽  
Lewis X ◽  
High Endothelial Venules ◽  
Sialyl Lewis ◽  
Selectin Ligand

YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis Through Activating Yap Signaling in Vascular Endothelial Cells

2020 ◽  
Author(s):  
Yu Yan ◽  
Qiang Song ◽  
Li Yao ◽  
Liang Zhao ◽  
Hui Cai
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Tumor Angiogenesis ◽  
Breast Cancer Cells ◽  
Vascular Endothelial Cells ◽  
Tissue Growth ◽  
Vascular Endothelial ◽  
Potential Marker

Abstract Background:The YAP signaling pathway is altered and implicated as oncogenic in human mammary cancers.However, roles of YAP signaling that regulate the breast tumor angiogenesis have remained elusive. Tumor angiogenesis is coordinated by the activation of both cancer cells and vascular endothelial cells. Whether the YAP signalingpathway can regulate the intercellular interaction between cancer cells and endothelial cellsis essentially unknown.Results: We showed here that conditioned media from YAP overexpressed breast cancer cells (CM-YAP+) could promote angiogenesis, accompanied byincreased tube formation, migration, and proliferation of human umbilical vein endothelial cells (HUVECs). Down regulation of YAP in HUVECs reversed CM-YAP+ induced angiogenesis.CM-YAP+ time-dependently activated YAP inHUVECs by dephosphorylating YAP and increasing nuclear translocation.We also identified that both G13-RhoA and PI3K/Akt signaling pathway were necessary for CM-YAP+ induced activation of YAP.Besides, connective tissue growth factor (CTGF) and angiopoietin-2 (ANG-2)actedas down-stream of YAP in HUVECs to promote angiogenesis.In addition, subcutaneous tumors nude mice model demonstrated that tumors overexpressed YAP revealed moreneovascularization in vivo.Conclusions: YAP-YAP interaction between breastcancer cells and endothelial cellscould promote tumor angiogenesis, supporting that YAP is a potential marker and target fordeveloping novel therapeutic strategies against breast cancer.

scholarly journals VEGFR-2 Inhibitor Apatinib Hinders Endothelial Cells Progression Triggered by Irradiated Gastric Cancer Cells-derived Exosomes

2018 ◽  
Vol 9 (21) ◽  
pp. 4049-4057 ◽  
Author(s):  
Guangxin Li ◽  
Haishan Lin ◽  
Ruyue Tian ◽  
Pengfei Zhao ◽  
Yongjie Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Gastric Cancer Cells

Elastase Activity Enhances the Adhesion of Neutrophil and Cancer Cells to Vascular Endothelial Cells

2000 ◽  
Vol 94 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Fumiaki Nozawa ◽  
Masahiko Hirota ◽  
Akihiro Okabe ◽  
Muneyuki Shibata ◽  
Takeshi Iwamura ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cancer Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Elastase Activity
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