scholarly journals Effects of dexmedetomidine on oxidative stress and inflammatory response in lungs during mechanical ventilation in COPD rats

2019 ◽  
Author(s):  
Pengcheng Li ◽  
Jing Han ◽  
Dan Zhang ◽  
Shu Cao ◽  
Chunyu Su
Keyword(s):  
Oxidative Stress ◽  
Mechanical Ventilation ◽  
Inflammatory Response

scholarly journals Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Chaoliang Tang ◽  
Juan Li ◽  
Shaoqing Lei ◽  
Bo Zhao ◽  
Zhetao Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Mechanical Ventilation ◽  
Lung Injury ◽  
Inflammatory Response ◽  
Protective Ventilation ◽  
Current Evidence ◽  
Lung Protective Ventilation ◽  
Hemodynamic Variables ◽  
And Oxidative Stress

Current evidence indicates that conventional mechanical ventilation often leads to lung inflammatory response and oxidative stress, while lung-protective ventilation (LPV) minimizes the risk of ventilator-associated lung injury (VALI). This study evaluated the effects of LPV on relief of pulmonary injury, inflammatory response, and oxidative stress among patients undergoing craniotomy. Sixty patients undergoing craniotomy received either conventional mechanical (12 mL/kg tidal volume [VT] and 0 cm H2O positive end-expiratory pressure [PEEP]; CV group) or protective lung (6 mL/kg VT and 10 cm H2O PEEP; PV group) ventilation. Hemodynamic variables, lung function indexes, and inflammatory and oxidative stress markers were assessed. The PV group exhibited greater dynamic lung compliance and lower respiratory index than the CV group during surgery (P<0.05). The PV group exhibited higher plasma interleukin- (IL-) 10 levels and lower plasma malondialdehyde and nitric oxide and bronchoalveolar lavage fluid, IL-6, IL-8, tumor necrosis factor-α, IL-10, malondialdehyde, nitric oxide, and superoxide dismutase levels (P<0.05) than the CV group. There were no significant differences in hemodynamic variables, blood loss, liquid input, urine output, or duration of mechanical ventilation between the two groups (P>0.05). Patients receiving LPV during craniotomy exhibited low perioperative inflammatory response, oxidative stress, and VALI.

Naringin Inhibits TNF-α Induced Oxidative Stress and Inflammatory Response in HUVECs via Nox4/NF-κ B and PI3K/Akt Pathways

2014 ◽  
Vol 15 (12) ◽  
pp. 1173-1182 ◽  
Author(s):  
Wenshuang Li ◽  
Changyuan Wang ◽  
Jinyong Peng ◽  
Jing Liang ◽  
Yue Jin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response

scholarly journals E-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models

2021 ◽  
pp. 105234
Author(s):  
Careen Khachatoorian ◽  
Wentai Luo ◽  
Kevin J. McWhirter ◽  
James F. Pankow ◽  
Prue Talbot
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Human Keratinocytes ◽  
3D Skin

Oxidative stress and inflammatory response to printer toner particles in human epithelial A549 lung cells

2013 ◽  
Vol 216 (2-3) ◽  
pp. 171-180 ◽  
Author(s):  
Mathias Könczöl ◽  
Adilka Weiß ◽  
Richard Gminski ◽  
Irmgard Merfort ◽  
Volker Mersch-Sundermann
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Lung Cells ◽  
A549 Lung

scholarly journals Oxidative stress in patients on mechanical ventilation

2009 ◽  
Vol 62 (11-12) ◽  
pp. 578-581
Author(s):  
Vesna Marjanovic ◽  
Vidosava Djordjevic ◽  
Goran Marjanovic
Keyword(s):  
Oxidative Stress ◽  
Mechanical Ventilation ◽  
Head Injuries ◽  
Lipid Peroxide ◽  
Thiobarbituric Acid ◽  
Lactic Dehydrogenase ◽  
Lung Damage ◽  
Thiobarbituric Acid Reactive Substances ◽  
Acid Base Balance ◽  
Arterial Blood

Introduction. The appearance and intensity of oxidative stress were analyzed in the course of mechanical ventilation and parameters that could point toward potential lung damage. Material and methods. In three time intervals on day 1, 3 and 7 of mechanical ventilation, parameters such as: triglycerides, cholesterol, lactate, serum lactic dehydrogenase, acid-base balance and lipid peroxidation products - thiobarbituric acid reactive substances, were followed in 30 patients with head injuries. Results. A decrease in the level of partial oxygen pressure (PaO2) (p<0.01) and PaO2/FiO2 index (p<0.05) in arterial blood was recorded on day 3 of mechanical ventilation. This was accompanied with an increase in alveolar-arterial difference (AaDO2) (p<0.05), thiobarbituric acid reactive substances (p<0.001) and lactic dehydrogenase (p<0.001) comparing to day 1 of mechanical ventilation. The patients with initial PaO2>120 mmHg, had significant increase of thiobarbituric acid reactive substances and AaDO2 (p<0.05) and fall of PaO2 (p<0.001) on day 3 of mechanical ventilation. Conclusion. Oxidative stress and lipid peroxide production are increased during third day of mechanical ventilation leading to disruption of oxygen diffusion through alveolar-capillary membrane and reduction of parameters of oxygenation.

scholarly journals Why so little effort to study anti-oxidant therapy in burns?

2016 ◽  
Vol 4 ◽  
pp. 1-2 ◽  
Author(s):  
Gordon L. Klein
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Inflammatory Response ◽  
Burn Injury ◽  
Burn Treatment ◽  
Gamma Tocopherol ◽  
Limited Success ◽  
Anti Oxidant

Abstract Given that oxidative stress is an inherent response to burn injury, it is puzzling as to why investigation into anti-oxidant therapy as an adjunct to burn treatment has been limited. Both the inflammatory response and the stress response to burn injury involve oxidative stress, and there has been some limited success in studies using gamma tocopherol and selenium to improve certain consequences of burns. Much remains to be done to investigate the number, doses and combinations of anti-oxidants, their efficacy, and limitations in improving defined outcomes after burn injury.

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