scholarly journals Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain‑1 expression and inhibits NF‑κB activation in streptozotocin‑induced diabetic rats

2019 ◽  
Author(s):  
Qianqian Liu ◽  
Qianqian Han ◽  
Meili Lu ◽  
Hongxin Wang ◽  
Futian Tang
Keyword(s):  
Cardiac Hypertrophy ◽  
Diabetic Rats ◽  
Lycium Barbarum ◽  
Lycium Barbarum Polysaccharide

Hypoglycemic and Hypolipidemic Effects of Lycium barbarum Polysaccharide in Diabetic Rats

2015 ◽  
Vol 7 (4) ◽  
pp. 310-315 ◽  
Author(s):  
Rong Zhao ◽  
Rui Jin ◽  
Yong Chen ◽  
Feng-mei Han
Keyword(s):  
Diabetic Rats ◽  
Lycium Barbarum ◽  
Lycium Barbarum Polysaccharide

Protective effect of Lycium barbarum polysaccharide 4 on kidneys in streptozotocin-induced diabetic rats

2009 ◽  
Vol 87 (9) ◽  
pp. 711-719 ◽  
Author(s):  
Rui Zhao ◽  
Qing-wang Li ◽  
Jian Li ◽  
Tao Zhang
Keyword(s):  
Protective Effect ◽  
Mesangial Cells ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Protective Mechanism ◽  
Lycium Barbarum ◽  
Physiological Level ◽  
Extracellular Signal ◽  
Lycium Barbarum Polysaccharide

Lycium barbarum polysaccharide (LBP) has been shown to have hypoglycemic and antioxidative properties, although its mode of action is yet unknown. Because oxidative stress is implicated in the pathogenesis of diabetic nephropathy, we evaluated the protective effect of LBP-4, the major active component of Lycium barbarum, on the defensive antioxidative mechanism in kidneys in a streptozotocin-induced diabetic rat model. Moreover, we investigated the effects of LBP-4 on the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in isolated mesangial cells. The role of protein kinase C (PKC)-dependent and -independent pathways in LBP-4-reduced ERK1/2 was studied by bisindolylmaleimide (BIM) IV, an inhibitor of PKC. Diabetic rats treated with LBP-4 (10 mg/kg) for 8 weeks showed increased activity of antioxidant enzymes and increased scavenging of oxygen radicals, while the activity of PKC in the renal cortex was maintained at a physiological level. The decreased activation of ERK1/2 in mesangial cells, through the involvement of PKC, could explain the protective mechanism in kidneys of diabetic rats treated with LBP-4.

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