scholarly journals Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome

2019 ◽  
Author(s):  
Li Ma ◽  
Liang Li ◽  
Ping Han ◽  
Fanchun Meng ◽  
Chunhong Jiao ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Drug Combination ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

scholarly journals Fibronectin and C-reactive protein in pregnancy induced hypertension

2003 ◽  
Vol 22 (4) ◽  
pp. 325-328
Author(s):  
Svetlana Djuricic ◽  
Marina Stojanov ◽  
Ivana Obradovic ◽  
Aleksandar Glisic ◽  
Darko Plecas
Keyword(s):  
Normal Pregnancy ◽  
Medical Complication ◽  
Pregnancy Induced Hypertension ◽  
Plasma Fibronectin ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nephelometric Method ◽  
Induced Hypertension ◽  
The One ◽  
In Pregnancy

Hypertension is the most common medical complication in pregnancy. Of the varying forms of hypertension that can effect pregnancy pre-eclampsia is the one specific to pregnant women. The differential diagnosis between pre-eclampsia and pregnancy induced hypertension (PIH) is essential to proper management of pregnancy. The aim of this study was to examine the effect of hypertension on plasma fibronectin and C-reactive protein (CRP) during gestatation. The examined groups comprised 37 patients with normal pregnancy and 30 with PIH between 24 and 36 weeks of gestation. Plasma fibronectin and CRP were both assayed by nephelometric method. The obtained results for both examined parameters were significantly higher in PIH group than in controls (p < 0.05). A positive correlation was found between fibronectin, CRP and weeks of gestation (p < 0.05). Therefore, we can conclude that plasmatic fibronectin and CRP are among useful screening parameters for estimation of the endothelial injury in hypertensive disorders of pregnancy.

scholarly journals C - reactive protein levels in women with pregnancy induced hypertension

1970 ◽  
Vol 10 (3) ◽  
pp. 159-162 ◽  
Author(s):  
TK Ghosh ◽  
S Ghosh ◽  
D Bhattacharjee
Keyword(s):  
Normal Control ◽  
Hematological Parameter ◽  
Adult Women ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Medical College ◽  
Protein Levels ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Pregnant Mothers

Objective: The main objective of this study is to determine the level of C- reactive protein in pregnancy induced hypertension (PIH) along its relation with normal pregnant mothers and also to compare it with different grades of pregnancy. C-reactive protein and inflammation are interrelated. Another objective of this study is to find out the relationship of C- reactive protein, biochemical and hematological parameter in PIH as well as its clinical correlation. Materials and Methods: The study was conducted in the department of Gynaecology and department of Pathology in Burdwan Medical College West Bengal India after taking permission from ethical committee. 50 cases of PIH mothers and age and gestational matched 50 cases of normal control pregnant mothers and 50 normal healthy non pregnant adult women were included in this present study. CRP was estimated by turbidometric method. Serum Uric acid, SGPT, Serum Creatinine were estimated by semi auto analyzer, Serum ß HCG was estimated by ELISA technique. The total leukocytes count, absolute Neutrophils count, Platelet counts were done in hematological cell counter with correlation from peripheral direct smear and manual counting. Urine protein was detected by dipstick method. Results: Serum C- reactive protein was positively correlated with severity of in PIH. Results shows a significantly increased C-reactive protein in PIH (Mean SD 42.02 mg/L±18 .01 mg/L, P<0.001) in comparison to normal control mother (Mean SD 4.2 ±0.93 mg/L). Conclusion: Serum C-reactive protein levels can be used as marker for early diagnosis and intervention of PIH and can be reduced maternal as well as fetal morbidity and mortality. Key words: C - reactive protein, pregnancy induced hypertension. DOI: http://dx.doi.org/ 10.3329/bjms.v10i3.8358 BJMS 2011; 10(3): 159-162

Abstract 277: Elevated C-Reactive Protein Contributes to Preeclampsia via Kinin Signaling Pathways

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Nicholas Parchim ◽  
Wei Wang ◽  
Takayuki Iriyama ◽  
Chen Liu ◽  
Athar H Siddiqui ◽  
...  
Keyword(s):  
Acute Phase Reactant ◽  
Receptor Activation ◽  
C Reactive Protein ◽  
Direct Role ◽  
Human Trophoblast ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Pregnant Mice

Preeclampsia (PE) is a serious pregnancy disease characterized by hypertension and proteinuria. Despite intensive research efforts, the underlying cause of PE remains a mystery. PE is, however, associated with abnormalities of the immune system. Here we report that the levels of C-reactive protein (CRP), an important acute phase reactant, were significantly elevated in the plasma of human with PE at the third trimester. Next, we found that CRP protein levels in the placentas of PE patients were also significantly increased compared to controls. In an effort to determine the exact role of elevated CRP in PE, we infused CRP into pregnant mice. We found that injection of CRP into pregnant mice induced hypertension (170 mmHg mean systolic vs. 125 mmHg mean systolic control; p<0.05) and proteinuria (25 mg/ug vs 12 mg/ug vehicle; p<0.05), indicating the direct role of CRP in PE. CRP is known to bind with phosphocholine on damaged cell membranes. Recent studies identified that neurokinin B (NKB), a placental enriched neuropeptide and known pathogenic molecule for PE, is phosphocholinated. This posttranslational modification increases its stability and enhances NKB-mediated receptor activation. These findings raise an intriguing hypothesis that CRP may bind with NKB coupled to NK3R activation and contribute to PE. To test this hypothesis, we conducted a pulldown assay, and we found that CRP bound with NKB. Next, using a cellular invasion assay, we revealed that CRP decreased invasion of human trophoblast cells (0.7 to 0.07 invasion index, p<0.05), while treatment with an NK3R selective antagonist, SB222200, ameliorated this shallow invasion. Finally, we provided in vivo evidence that inhibition of NK3R by SB222200 or knockdown of NK3R by specific siRNA in a potent nanoparticle delivery system significantly reduced CRP-induced hypertension and proteinuria in pregnant mice (170 mmHg mean systolic CRP-injected vs. 130 mmHg mean systolic siRNA NK3R; p<0.05 and proteinuria 25 mg/ug vs. 15 mg/ug; p<0.05). Overall, our findings demonstrate that elevated CRP contributes to PE and NKB/NK3R is a novel mechanism underlying CRP-mediated shallow invasion and disease development. These studies suggest novel pathogenic biomarkers and innovative therapeutic targets for PE.

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