scholarly journals Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis

2019 ◽  
Author(s):  
Jian Lu ◽  
Hong‑Wei Zhao ◽  
Yu Chen ◽  
Jin‑Huan Wei ◽  
Zhen‑Hua Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Translation Initiation ◽  
Poor Prognosis ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Eukaryotic Translation Initiation Factor ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation

scholarly journals Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

2009 ◽  
Vol 2009 ◽  
pp. 1-12 ◽  
Author(s):  
Biljana Culjkovic ◽  
Katherine L. Borden
Keyword(s):  
Translation Initiation ◽  
Poor Prognosis ◽  
Suicide Gene ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Human Leukemia ◽  
Eukaryotic Translation Initiation Factor ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation ◽  
Clinical Responses

The eukaryotic translation initiation factor eIF4E is elevated in about 30% of human malignancies including HNSCC where its levels correlate with poor prognosis. Here, we discuss the biochemical and molecular underpinnings of the oncogenic potential of eIF4E. Studies in human leukemia specimens, and later in a mouse model of prostate cancer, strongly suggest that cells with elevated eIF4E develop an oncogene dependency to it, making them more sensitive to targeting eIF4E than normal cells. We describe several strategies that have been suggested for eIF4E targeting in the clinic: the use of a small molecule antagonist of eIF4E (ribavirin), siRNA or antisense oligonucleotide strategies, suicide gene therapy, and the use of a tissue-targeting 4EBP fusion peptide. The first clinical trial targeting eIF4E indicates that ribavirin effectively targets eIF4E in poor prognosis leukemia patients and more importantly leads to striking clinical responses including complete and partial remissions. Finally, we discuss the relevance of these findings to HNSCC.

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