scholarly journals Crocin promotes apoptosis of human skin cancer cells by inhibiting the JAK/STAT pathway

2018 ◽  
Author(s):  
Gongfeng Wang ◽  
Baofang Zhang ◽  
Yanyan Wang ◽  
Shunli Han ◽  
Chenghong Wang
Keyword(s):  
Skin Cancer ◽  
Cancer Cells ◽  
Human Skin ◽  
Stat Pathway

Enhanced Expression of Fibroblast Growth Factor Receptor 3 in Human Skin Cancer Cells

2009 ◽  
Vol 2 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Motoki Terada ◽  
Chikara Ohnishi ◽  
Nobuhiro Ueno ◽  
Akio Shimizu ◽  
Michiyuki Kanai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Skin Cancer ◽  
Cancer Cells ◽  
Fibroblast Growth Factor ◽  
Human Skin ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Enhanced Expression

p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells

2013 ◽  
Vol 267 (1) ◽  
pp. 113-124 ◽  
Author(s):  
Shi-Wei Huang ◽  
Chun-Ying Wu ◽  
Yen-Ting Wang ◽  
Jun-Kai Kao ◽  
Chi-Chen Lin ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Cells ◽  
Human Skin ◽  
Compound C ◽  
Induced Apoptosis

scholarly journals Apoptosis and antimigration induction in human skin cancer cells by rhodomyrtone

2018 ◽  
Author(s):  
Malatee Tayeh ◽  
Sirinun Nilwarangkoon ◽  
Chantra Tanunyutthawongse ◽  
Wilawan Mahabusarakum ◽  
Ramida Watanapokasin
Keyword(s):  
Skin Cancer ◽  
Cancer Cells ◽  
Human Skin

scholarly journals Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state

RNA ◽  
2008 ◽  
Vol 14 (10) ◽  
pp. 2115-2124 ◽  
Author(s):  
S.-L. Lin ◽  
D. C. Chang ◽  
S. Chang-Lin ◽  
C.-H. Lin ◽  
D. T.S. Wu ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Cells ◽  
Human Skin ◽  
Es Cell

Ether Aryl Sulfonic Acid Esters with Improved Antimalarial/Anticancer Activities

2006 ◽  
Vol 59 (4) ◽  
pp. 277 ◽  
Author(s):  
Lynn M. Betts ◽  
Nga Chiu Tam ◽  
S. M. Humayun Kabir ◽  
Richard F. Langler ◽  
Ian Crandall
Keyword(s):  
Skin Cancer ◽  
Cancer Cells ◽  
Human Skin ◽  
Sulfonic Acid ◽  
Anticancer Agent ◽  
Anticancer Activities ◽  
Antimalarial Agent ◽  
Acid Esters

Our previous report showed that our current benchmark agent, 4-methoxyphenyl p-toluenesulfonate, is a selective antimalarial/anticancer agent. A series of related sulfones and sulfonic acid esters is now examined. 4-Allyloxyphenyl p-toluenesulfonate is a superior antimalarial/anticancer agent. 4-Methoxyphenyl 4-nitrobenzenesulfonate is a superior antimalarial agent, but shows poorer inhibition of human skin cancer cells.

Ugonin K Induces Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species/Apoptosis Signal Pathway in Human Skin Cancer Cells

2013 ◽  
Vol 690-693 ◽  
pp. 1422-1425
Author(s):  
Leong Perng Chan ◽  
Tzung Han Chou ◽  
Guey Horng Wang ◽  
Ya Ping Tseng ◽  
Pin Ju Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Human Skin ◽  
Antioxidant Activities ◽  
Reactive Oxygen ◽  
Hacat Cells ◽  
Oxygen Species

The incidence and mortality of skin cancer continue to rise because of the destruction of the ozonosphere in the earth. Skin cancer is divided into two groups by histological features – nonmelanoma skin cancers (NMSC) and melanoma. Cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of NMSC are almost 75% among human skin malignancy cancer. In the preliminary bioactivity screening, the compound isolated from Helminthostachys zeylanica were evaluated antioxidant activities and interacted individually with serial human cancer cells, results that antioxidant activities of ugonin K were evaluated by measuring DPPH free-radical scavenging activities, and reducing power. Determination the reactive oxygen species (ROS) content and reduced glutathione (GSH) formation in H2O2-treated HaCaT cells by ugonin K. The cytotoxicity results show that ugonin K expressed less toxic to human keratinocytes (HaCaT cells) and human skin fibroblasts (Hs68 cells) than BCC cells, suggesting that ugonin K may have potential to be developed effective drugs for skin cancer cells without damaging skin normal cells. After treatment with ugonin K in BCC cells, cell cycle arrested in S-G2/M phase with a markedly increased apoptotic sub-G1 peak, mitochondria membrane potential (MMP) reduced, the expression of p53, Caspase-8, Caspase-9 and Caspase-3 revealed a more significant increased than the untreated control. Expected ugonin K has potential for an effective and specific drug to cancer cell, can minimize the damage to normal cell and provide a better therapeutic method to skin carcinoma.

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