scholarly journals Correlation between coronary artery disease and obstructive sleep apnea syndrome and analysis of risk factors

Author(s):  
Jidong Zhang ◽  
Yu Song ◽  
Yang Ji ◽  
Yiying Song ◽  
Shanglang Cai ◽  
...  
2013 ◽  
Vol 36 (6) ◽  
pp. 306 ◽  
Author(s):  
Xizhong Sui ◽  
Changqing Gao

Purpose: Current evidence supports a robust association between obstructive sleep apnea syndrome (OSAS) and the risk of coronary artery disease (CAD). YKL-40, a 40 kDa heparin- and chitin-binding glycoprotein, is found to be associated with the presence of CAD. This study aims to examine the association of serum levels of YKL-40 with the presence and severity of CAD in patients with OSAS. Methods: A total of 246 patients with OSAS who underwent coronary angiography for the evaluation of CAD (134 patients with CAD and 112 patients without CAD) were enrolled in this study. The severity of CAD was assessed using the coronary atherosclerosis index (CAI). Serum levels of YKL-40 were determined using enzyme-linked immunosorbent assay. Results: Serum YKL-40 levels were significantly higher in OSAS patients with CAD compared with those without CAD. Multivariable logistic regression analysis revealed that serum YKL-40 levels were an independent determinant of the presence of CAD in patients with OSAS. In addition, Spearman correlation analysis showed that serum YKL-40 levels were positively correlated with CAI in OSAS patients with CAD. Patients with statin treatment showed significantly lower levels of serum YKL-40 compared with those without. Conclusions: Elevated levels of serum YKL-40 are associated with the presence and severity of CAD in patients with OSAS.


2014 ◽  
Vol 15 (5) ◽  
pp. 402-406 ◽  
Author(s):  
Davide Capodanno ◽  
Giovanni Milazzo ◽  
Miriam Cumbo ◽  
Anna Marchese ◽  
Antonella Salemi ◽  
...  

2005 ◽  
Vol 6 (1) ◽  
pp. 163-164
Author(s):  
E. Vlachogiannis ◽  
C.H. Liavvas ◽  
Z. Koukoulidou ◽  
A. Dougalis ◽  
A. Mousiolis ◽  
...  

2006 ◽  
Vol 4 (2) ◽  
pp. 144-152 ◽  
Author(s):  
Akiko YOSHINO ◽  
Maki HIGUCHI ◽  
Fusae KAWANA ◽  
Mitsue KATO ◽  
Minae KAMATA ◽  
...  

2012 ◽  
Vol 13 (8) ◽  
pp. 1028-1032 ◽  
Author(s):  
Renata G. Koyama ◽  
Andrea M. Esteves ◽  
Luciana Oliveira e Silva ◽  
Fabio S. Lira ◽  
Lia R.A. Bittencourt ◽  
...  

2011 ◽  
Vol 1 (1) ◽  
pp. 13-21
Author(s):  
Ayman B. Krayem ◽  
Ayah M. Boudal

Obstructive sleep apnea is a common disorder, generally under-recognized and hence under diagnosed. It is associated with potentially serious morbidity and increasing mortality which can be prevented by early diagnosis, modification of risk factors and proper treatment. In this review, basic and updated information of obstructive sleep apnea of interest to internists and general physicians will be discussed. This includes important definitions, epidemiology, risk factors, diagnosis, pathophysiology, complications, mortality, and modalities of treatment.


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