scholarly journals Application values of miR-194 and miR-29 in the diagnosis and prognosis of gastric cancer

2018 ◽  
Author(s):  
Xin Zhao ◽  
Yunxia Hou ◽  
Zhongzhen Tuo ◽  
Fangmeng Wei
Keyword(s):  
Gastric Cancer ◽  
Diagnosis And Prognosis

Overexpression of a novel oncogene Cadherin 6 correlates with tumor progression and poor prognosis in gastric cancer

2021 ◽  
Author(s):  
Zongxian Zhao ◽  
Shuliang Li ◽  
Shilong Li ◽  
Jun Wang ◽  
Hai Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Roc Curve ◽  
Cox Regression ◽  
Gene Set Enrichment Analysis ◽  
Expression Level ◽  
Diagnostic Efficiency ◽  
Gastric Tissue ◽  
Diagnosis And Prognosis ◽  
T Classification

Abstract BackgroundGastric cancer (GC) is one of the most common and fatal cancers worldwide and effective biomarkers aids in GC management and prognosis. Hence, we explored the role and function of cadherin 6 (CDH6) in diagnosis and prognosis of gastric cancer. MethodsThe expression level of CDH6 in GC tissue and normal gastric tissue were analyzed using multiple public databases. Gene set enrichment analysis (GSEA) was performed using The Cancer Genome Atlas dataset (TCGA). The diagnostic efficiency of CDH6 expression in GC patients was determined through receiver operating characteristic (ROC) curve analysis. The associations between clinical variables and expression of CDH6 were evaluated statistically and the prognostic factors for overall survival were analyzed by univariate and multivariate Cox regression. Forty-four GC tissues, corresponding adjacent normal tissues (n=20), and detailed clinical information were collected from Tianjin Medical University General Hospital, CDH6 expression level was detected for further validation. ResultsCDH6 was upregulated in GC samples compared with normal gastric tissue, and GSEA identified the citrate cycle tricarboxylic (TCA) cycle, extracellular matrix (ECM) receptor interaction, glyoxylate and dicarboxylate metabolism oxidative phosphorylation, and pentose phosphate pathway as differentially enriched in GCs. According to the area under the ROC curve (AUC) (AUC=0.829 in TCGA and 0.966 in GSE54129), CDH6 had high diagnostic efficiency. Patients with high expression of CDH6 was associated with higher T classification and worse prognoses than those with low CDH6 expression in GC. Univariate and multivariate Cox regression analysis showed that CDH6 was an independent risk factor for overall survival (univariate: HR = 1.305, P = 0.002, multivariate: HR = 1.481, P < 0.001). ConclusionCDH6 was upregulated in GC and high CDH6 expression indicated higher T classification and worse prognoses. CDH6 could be a potentially independent molecular biomarker for diagnosis and prognosis of GC.

scholarly journals Overexpression of SULT2B1b Promotes Angiogenesis in Human Gastric Cancer

2016 ◽  
Vol 38 (3) ◽  
pp. 1040-1054 ◽  
Author(s):  
Wen Chen ◽  
Haiyu Zhou ◽  
Lei Ye ◽  
Baogen Zhan
Keyword(s):  
Gastric Cancer ◽  
Hepatocellular Carcinoma ◽  
Endothelial Cells ◽  
Cancer Progression ◽  
Human Gastric Cancer ◽  
Qrt Pcr ◽  
Diagnosis And Prognosis ◽  
Promising Strategy ◽  
Oncogenic Protein ◽  
Gastric Cancer Progression

Background/Aims: Overexpression of cytosolic sulfotransferase 2B1b (SULT2B1b) has been commonly found in colorectal and hepatocellular carcinoma, suggesting that SULT2B1b might act as a potential oncogenic protein. However, its clinical significance and biological role in gastric cancer progression remain largely unknown. Methods: Expressions of SULT2B1b in clinical gastric cancer (GC) samples were examined using qRT-PCR and Western blot. Results: SULT2B1b was markedly overexpressed in human GC samples, and positively correlated with vessel density and associated with poor clinical features. We also demonstrated that overexpression of SULT2B1b resulted in increased tumor angiogenesis and tumor growth in mouse GC models. In addition, ablation of SULT2B1b in human GC cells lines BGC823 and MKN45 decreased the capability of the cells to recruit endothelial cells. Moreover, depletion of SULT2B1b in GC cells reduced VEGF-A expression by downregulating SP1 and AP2. Conclusion: Our results suggested that the SULT2B1b-mediated angiogenic pathway could serve as biomarkers for GC diagnosis and prognosis, and suppressing SULT2B1b-mediated angiogenic signaling might be a promising strategy for developing novel GC treatment.

scholarly journals MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer

2015 ◽  
Vol 22 (6) ◽  
pp. 291-301 ◽  
Author(s):  
C Jiang ◽  
X Chen ◽  
M Alattar ◽  
J Wei ◽  
H Liu
Keyword(s):  
Gastric Cancer ◽  
Diagnosis And Prognosis

scholarly journals Combined Detection of CEA, CA 19-9, CA 242 and CA 50 in the Diagnosis and Prognosis of Resectable Gastric Cancer

2014 ◽  
Vol 15 (15) ◽  
pp. 6295-6300 ◽  
Author(s):  
Shu-Bo Tian ◽  
Jian-Chun Yu ◽  
Wei-Ming Kang ◽  
Zhi-Qiang Ma ◽  
Xin Ye ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Diagnosis And Prognosis ◽  
Ca 242 ◽  
Resectable Gastric Cancer ◽  
Ca 50 ◽  
Combined Detection

scholarly journals Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles

2021 ◽  
Vol 11 ◽  
Author(s):  
Kedeerya Aishanjiang ◽  
Xin-dong Wei ◽  
Yi Fu ◽  
Xinjie Lin ◽  
Yujie Ma ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Hepatocellular Carcinoma ◽  
Closed Loop ◽  
Therapeutic Potential ◽  
Therapeutic Targets ◽  
Circular Rnas ◽  
Diagnosis And Prognosis ◽  
Physiological Processes ◽  
Non Coding Rnas ◽  
Novel Targets

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Due to the lack of potent diagnosis and prognosis biomarkers and effective therapeutic targets, the overall prognosis of survival is poor in HCC patients. Circular RNAs (circRNAs) are a class of novel endogenous non-coding RNAs with covalently closed loop structures and implicated in diverse physiological processes and pathological diseases. Recent studies have demonstrated the involvement of circRNAs in HCC diagnosis, prognosis, development, and drug resistance, suggesting that circRNAs may be a class of novel targets for improving HCC diagnosis, prognosis, and treatments. In fact, some artificial circRNAs have been engineered and showed their therapeutic potential in treating HCV infection and gastric cancer. In this review, we introduce the potential of circRNAs as biomarkers for HCC diagnosis and prognosis, as therapeutic targets for HCC treatments and discuss the challenges in circRNA research and chances of circRNA application.

scholarly journals Biogenesis, functions and clinical significance of circRNAs in gastric cancer

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Chan Shan ◽  
Yinfeng Zhang ◽  
Xiaodan Hao ◽  
Jinning Gao ◽  
Xinzhe Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Mechanisms ◽  
Disease Diagnosis ◽  
Biological Properties ◽  
Circular Rnas ◽  
High Morbidity ◽  
Malignant Tumours ◽  
Diagnosis And Prognosis ◽  
Covalently Linked ◽  
New Biomarkers

Abstract Gastric cancer (GC) is one of the most common malignant tumours in the world and has high morbidity and mortality. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently linked circular structures. In recent years, plentiful circRNAs have been discovered that participate in many biological processes, including the initiation and development of tumours. Increasing evidences suggest important biological functions of circRNAs, implying that circRNAs may serve as vital new biomarkers and targets for disease diagnosis and prognosis. Among these, circRNAs are tend to aberrantly expressed and are regarded as potential biomarkers in the carcinogenesis and progression of GC. This review systematically summarised the biogenesis, biological properties and functions of circRNAs, with a focus on their relationship with GC, as well as their probable clinical implications on GC. As our cognition of the relation between circRNAs and GC deepens, more molecular mechanisms of GC progression will be discovered, and new therapeutic strategies will be used for the prevention and treatment of GC.

Gastric juice piR-1245: A promising prognostic biomarker for gastric cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16574-e16574
Author(s):  
Wei Peng ◽  
Jianhong Liu ◽  
Xiaorong Zhou ◽  
Hong Fan ◽  
Jianwei Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Juice ◽  
Cox Regression ◽  
Progression Free Survival ◽  
Healthy Individuals ◽  
Free Survival ◽  
Cox Regression Analysis ◽  
Diagnosis And Prognosis ◽  
Potential Marker ◽  
Risk Variable

e16574 Background: Emerging reports demonstrated that PIWI-interacting RNAs (piRNAs) played an indispensable role in tumorigenesis. However, it still remains elusive whether piR-1245 in gastric juice specific in stomach could be employed as a biomarker for gastric cancer (GC). The present work is aiming at exploring the possibility of piR-1245 in gastric juice as a potential marker to judge for diagnosis and prognosis of gastric cancer. Methods: Gastric juice was collected from 66 GC patients and 66 healthy individuals. Quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) was employed to measure the levels of piR-1245 expression. Then, the pattern of piR-1245 expression in gastric juice was determined between GC patients and healthy individuals. A receiver operating characteristic (ROC) curve was constructed for distinguishing GC from healthy individuals. Results: Gastric juice piR-1245 levels in GC were higher than those of controls (P < 0.0001). The value of area under ROC (AUC) was 0.885 (sensitivity, 90.9%; specificity, 74.2%; 95% confidence interval, 0.8286 to 0.9414). High gastric juice piR-1245 expression was signally correlated with tumor size (P = 0.013) and TNM stage (P = 0.001). GC patients with high piR-1245 expression in gastric juice exerted a poorer overall survival (OS) (P = 0.0152) and progression-free survival (PFS) (P = 0.013). COX regression analysis verified that gastric juice piR-1245 expression was an independent prognostic risk variable for OS (P < 0.05). Conclusions: The current study suggested that piR-1245 in gastric juice had the potential to be a useful biomarker for GC detection and prognosis prediction.

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