scholarly journals Enhanced antitumor activity of combined megestrol acetate and arsenic trioxide treatment in liver cancer cells

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Xianhao Liu ◽  
Beibei Liu ◽  
Xiaoshi Zhang ◽  
Geng Tian
2020 ◽  
Vol 10 ◽  
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Chin-Chuan Chen ◽  
Wen-Yu Chuang ◽  
Yann-Lii Leu ◽  
Shir-Hwa Ueng ◽  
...  

2017 ◽  
Vol 50 (4) ◽  
pp. 1299-1311 ◽  
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Ya-Hua Li ◽  
Gang Wu ◽  
Jian-Zhuang Ren ◽  
Hui-Bin Lu ◽  
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Life Sciences ◽  
2018 ◽  
Vol 205 ◽  
pp. 9-17 ◽  
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Nadra Sadaf ◽  
Nitish Kumar ◽  
Mehboob Ali ◽  
Vahab Ali ◽  
Sanjiva Bimal ◽  
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2006 ◽  
Vol 37 (3) ◽  
pp. 298-311 ◽  
Author(s):  
Xing Cui ◽  
Toshifumi Wakai ◽  
Yoshio Shirai ◽  
Naoyuki Yokoyama ◽  
Katsuyoshi Hatakeyama ◽  
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Author(s):  
A Henrici ◽  
R Montalbano ◽  
K Quint ◽  
M Ocker ◽  
P Di Fazio

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Zhen-hua Sui ◽  
Yan-Kun Liu ◽  
Hong Xie ◽  
Hui-jie Gao ◽  
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2020 ◽  
Vol 16 (4) ◽  
pp. 337-343
Author(s):  
Shaimaa E. Abdel-Ghany ◽  
Eman El-Sayed ◽  
Nour Ashraf ◽  
Nada Mokhtar ◽  
Amany Alqosaibi ◽  
...  

Background: Hepatocellular carcinoma is the second leading cause of cancer-related deaths among other types of cancer due to lack of effective treatments and late diagnosis. Nanocarriers represent a novel method to deliver chemotherapeutic drugs, enhancing their bioavailability and stability. Methods: In the present study, we loaded gold nanoparticles (AuNPs) and titanium oxide nanoparticles (TiO2NPs) with ERL to investigate the efficiency of the formed composite in inducing apoptosis in HepG2 liver cancer cells. Cytotoxicity was assessed using MTT assay and cell phase distribution was assessed by flow cytometry along with apoptosis detection. Results: Data obtained indicated the efficiency of the formed composite to significantly induce cell death and arrest cell cycle and G2/M phase. IRF4 was downregulated after treatment with loaded ERL. Conclusion: Our data showed that loading ERL on TiO2NPs was more efficient than AuNPs. However, both nanocarriers were efficient compared with control.


2021 ◽  
Author(s):  
Novi Angeline ◽  
Sung-Sik Choo ◽  
Cheol-Hwi Kim ◽  
Suk Ho Bhang ◽  
Tae-Hyung Kim

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