scholarly journals Effect of YHHJ on the expression of the hepatocellular bile acid transporters multidrug resistance‑associated protein 2 and bile salt export pump in ethinylestradiol‑induced cholestasis

2018 ◽  
Author(s):  
Jia Liu ◽  
Li‑Li Hou ◽  
Cui‑Ying Zhao
Keyword(s):  
Multidrug Resistance ◽  
Bile Acid ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Bile Acid Transporters

scholarly journals Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump

2001 ◽  
Vol 1511 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Hidetaka Akita ◽  
Hiroshi Suzuki ◽  
Kousei Ito ◽  
Setsuo Kinoshita ◽  
Norihito Sato ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Bile Acid ◽  
Bile Salt ◽  
Acid Transport ◽  
Bile Salt Export Pump ◽  
Bile Acid Transport

The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease

2019 ◽  
Vol 20 (5) ◽  
pp. 377-389 ◽  
Author(s):  
Xiaoyang Lu ◽  
Lin Liu ◽  
Wenya Shan ◽  
Limin Kong ◽  
Na Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Structure Function ◽  
Bile Salt ◽  
Drug Targets ◽  
Enterohepatic Circulation ◽  
Sodium Taurocholate ◽  
Bile Salt Export Pump ◽  
Bile Acid Transporters ◽  
Function Relationship ◽  
Related Liver Disease

Background:Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts. They have emerged as promising drug targets in related liver disease.Methods:We reviewed the literature published over the last 20 years with a focus on NTCP and BSEP.Results:This review summarizes the current perception about structure, function, genetic variation, and regulation of NTCP and BSEP, highlights the effects of their defects in some hepatic disorders, and discusses the application prospect of new transcriptional activators in liver diseases.Conclusion:NTCP and BSEP are important proteins for transportation and homeostasis maintenance of bile acids. Further research is needed to develop new models for determining the structure-function relationship of bile acid transporters and screening for substrates and inhibitors, as well as to gain more information about the regulatory genetic mechanisms involved in the processes of liver injury.

scholarly journals Measurement of Transport Activities of 3β-Hydroxy-Δ5-bile Acids in Bile Salt Export Pump and Multidrug Resistance-Associated Proteins Using LC-MS/MS

2013 ◽  
Vol 61 (5) ◽  
pp. 559-566 ◽  
Author(s):  
Tsuyoshi Murai ◽  
Kana Oda ◽  
Terutake Toyo ◽  
Hiroshi Nittono ◽  
Hajime Takei ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Bile Salt ◽  
Bile Acids ◽  
Bile Salt Export Pump ◽  
Associated Proteins
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