scholarly journals Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow

2017 ◽  
Author(s):  
Hongmei Niu ◽  
Zhenzhen Wei ◽  
Yanling Zhang ◽  
Jian He ◽  
Danyan Jia
Keyword(s):  
Endothelial Function ◽  
Coronary Flow ◽  
Slow Flow ◽  
Coronary Slow Flow

Evaluation of Plasma Thrombomodulin in Patients with Coronary Slow Flow

Cardiology ◽  
2017 ◽  
Vol 138 (3) ◽  
pp. 141-146 ◽  
Author(s):  
Yong Wang ◽  
Peng-yu Jia ◽  
Bao-jun Chen ◽  
Yan Chen ◽  
Hang Yu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Endothelial Dysfunction ◽  
Coronary Flow ◽  
Linear Regression Analysis ◽  
High Plasma ◽  
Control Group ◽  
Slow Flow ◽  
Distribution Width ◽  
Timi Frame Count ◽  
Coronary Slow Flow

Background: It has been reported that coronary slow flow (CSF) is associated with acute myocardial infarction, ventricular tachycardia, ventricular fibrillation, and even sudden cardiac death. Although studies concerning the etiopathogenesis of CSF are scarce, diffuse atherosclerosis and endothelial dysfunction are thought to play important roles. It has been suggested that a high plasma thrombomodulin (TM) level seems to play an important role in the pathogenesis of atherosclerosis and endothelial dysfunction. Objectives: We hypothesized that a high plasma TM level might be associated with CSF and aimed to research the relationship between plasma TM level and CSF. Methods: Fifty-two CSF patients with angiographically proven CSF and 44 cases with normal coronary flow were included in this study. Coronary flow velocity was determined by the thrombolysis in myocardial infarction (TIMI) frame count method. Plasma TM levels were measured in all the study subjects. Results: Plasma TM levels were significantly higher in the CSF group compared to the control group (3.9 ± 0.5 vs. 3.6 ± 0.3 ng/mL, p = 0.01). There was a positive relationship (r = 0.31, p = 0.002) between plasma TM level and mean TIMI frame count (TFC). Factors associated with mean TFC were plasma TM level (β = 0.206, p = 0.038) and red cell distribution width (β = 0.088, p = 0.009) in multiple linear regression analysis. Conclusions: Patients with CSF have a higher plasma TM level, and this may play an important role in the pathogenesis of CSF. An elevated plasma TM level may be a predictor of CSF. Future studies are needed to confirm these results.

scholarly journals Evolution of Coronary Flow in an Experimental Slow Flow Model in Swines: Angiographic and Pathological Insights

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Yupeng Bai ◽  
Liqun Hu ◽  
Delong Yu ◽  
Sheng Peng ◽  
Xiaogang Liu ◽  
...  
Keyword(s):  
Coronary Flow ◽  
Flow Model ◽  
Left Ventricular ◽  
Control Group ◽  
Large Animal ◽  
Slow Flow ◽  
Pathological Changes ◽  
Flow Phenomenon ◽  
Coronary Slow Flow ◽  
Coronary Slow Flow Phenomenon

Objective. Pathomechanism of coronary slow flow phenomenon remains largely unclear now. Present study observed the pathological and angiographic evolution in a pig model of coronary slow flow.Methods. Coronary slow flow was induced by repeat coronary injection of small doses of 40 µm microspheres in 18 male domestic pigs and angiographic and pathological changes were determined at 3 hours, 7 days, and 28 days after microspheres injection.Results. Compared to control group treated with coronary saline injectionn=6and baseline level, coronary flow was significantly reduced at 3 hours and 7 days but completely recovered at 28 days after coronary microsphere injection in slow flow group. Despite normal coronary flow at 28 days after microsphere injection, enhanced myocardial cytokine expression, left ventricular dysfunction, adverse remodelling, and ischemia/microembolism related pathological changes still persisted or even progressed from 3 hours to 28 days after coronary microsphere injection.Conclusions. Our results show that this large animal slow flow model could partly reflect the chronic angiographic, hemodynamic, and pathological changes of coronary slow flow and could be used to test new therapy strategies against the slow flow phenomenon.

scholarly journals Predictors of Coronary Slow Flow Phenomenon: A Retrospective Study

2019 ◽  
Vol 04 (02) ◽  
pp. 085-091
Author(s):  
Satish Kumar Rao V. ◽  
Indrani Garre
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Total Cholesterol ◽  
Inflammatory Markers ◽  
Coronary Flow ◽  
Control Group ◽  
Slow Flow ◽  
Lymphocyte Ratio ◽  
Coronary Slow Flow ◽  
Hs Crp

Abstract Aim This study aimed to analyze laboratory predictors, angiographic profile, clinical profile, and risk factors for coronary slow flow (CSF) phenomenon without coronary obstructive lesion in patients who came for a coronary angiogram. Materials and Methods The case-control study consisted of patients who underwent coronary angiography and were divided into two groups: patients with coronary slow flow (case group, n = 100) and patients with the normal coronary flow (control group, n = 100). Coronary flow was studied using corrected thrombolysis in myocardial infarction frame count (CTFC). The slow flow was defined as CTFC beyond 2 standard deviations from the normal published range. Risk factors including age, sex, diabetes mellitus (DM), hypertension, dyslipidemia, smoking, body mass index (BMI), hematological and biochemical parameters (complete blood picture, platelet count, total and differential leucocyte count, platelet-to-lymphocyte ratio [PLR], neutrophil-to-lymphocyte ratio [NLR] and lipid profile) were assessed. In both groups, clinical information was collected, and laboratory parameters were measured and compared. Results Patients with CSF were more likely to be male and active smokers. Total cholesterol, triglyceride, BMI, and DM were more commonly seen in the CSF group compared with the control group. Inflammatory markers like uric acid (p = 0.03) and high-sensitivity C-reactive protein (Hs-CRP) (p = 0.000) were found to be statistically significant. Hematocrit (p = 0.023), NLR (p = 0.001), total cholesterol (p = 0.000), triglycerides (p = 0.000), and BMI (p = 0.000) were statistically significant. PLR has the tendency of statistically significance (p = 0.059) BMI, total cholesterol, triglycerides, and Hs-CRP were strong predictors for CSF. Conclusion CSF was common in males, smokers, DM patients, and it was associated with high NLR, uric acid, and Hs-CRP levels. The independent predictor of CSF was BMI, total cholesterol, triglycerides, and Hs-CRP levels. These findings provide an impetus for additional studies to confirm the role of other inflammatory markers in CSF patients and treatment strategies depending on that.

Effect of Homocysteine-Induced Oxidative Stress on Endothelial Function in Coronary Slow-Flow

Cardiology ◽  
2007 ◽  
Vol 107 (4) ◽  
pp. 313-320 ◽  
Author(s):  
Halil Tanriverdi ◽  
Harun Evrengul ◽  
Yasar Enli ◽  
Omur Kuru ◽  
Deniz Seleci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
Slow Flow ◽  
Coronary Slow Flow

Endothelial Function, Oxidative Stress and Inflammatory Studies in Chronic Coronary Slow Flow Phenomenon Patients

Cardiology ◽  
2012 ◽  
Vol 121 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Victoria Kopetz ◽  
Jennifer Kennedy ◽  
Tamila Heresztyn ◽  
Irene Stafford ◽  
Scott R. Willoughby ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
Slow Flow ◽  
Flow Phenomenon ◽  
Coronary Slow Flow ◽  
Coronary Slow Flow Phenomenon

CORONARY FLOW WAS NOT FULLY DELAYED AT THE FIRST ADMINISTRATION OF CONTRAST IN PATIENTS WITH CORONARY SLOW FLOW PHENOMENON

2008 ◽  
Vol 9 (1) ◽  
pp. 216 ◽  
Author(s):  
K. Sadamatsu ◽  
T. Shikada ◽  
K. Nagaoka ◽  
K. Iwamoto ◽  
S. Sagara ◽  
...  
Keyword(s):  
Coronary Flow ◽  
Slow Flow ◽  
Flow Phenomenon ◽  
Coronary Slow Flow ◽  
Coronary Slow Flow Phenomenon
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