scholarly journals Role of stem cell growth factor/c-Kit in the pathogenesis of irritable bowel syndrome

2017 ◽  
Vol 13 (4) ◽  
pp. 1187-1193 ◽  
Author(s):  
Yuna Chai ◽  
Yusheng Huang ◽  
Hongmei Tang ◽  
Xing Tu ◽  
Jianbo He ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Irritable Bowel ◽  
Factor C ◽  
Stem Cell Growth Factor

scholarly journals Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice

PLoS ONE ◽  
2009 ◽  
Vol 4 (11) ◽  
pp. e8014 ◽  
Author(s):  
Payel Bhanja ◽  
Subhrajit Saha ◽  
Rafi Kabarriti ◽  
Laibin Liu ◽  
Namita Roy-Chowdhury ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Protective Role ◽  
Intestinal Stem Cell ◽  
Radiation Induced ◽  
Stem Cell Growth Factor

scholarly journals Stem cell growth factor receptor in canine vs. feline osteosarcomas

2016 ◽  
Vol 12 (4) ◽  
pp. 2485-2492 ◽  
Author(s):  
Birgitt Wolfesberger ◽  
Andrea Fuchs-Baumgartinger ◽  
Juraj Hlavaty ◽  
Florian R. Meyer ◽  
Martin Hofer ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Growth Factor Receptor ◽  
Stem Cell Growth Factor ◽  
Cell Growth Factor Receptor

Application of stem cell/growth factor system, as a multimodal therapy approach in regenerative medicine to improve cell therapy yields

2014 ◽  
Vol 173 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Fatemeh Pourrajab ◽  
Mojtaba Babaei Zarch ◽  
Mohammad Baghi Yazdi ◽  
Abolfazl Rahimi Zarchi ◽  
Abbas Vakili Zarch
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Multimodal Therapy ◽  
Therapy Approach ◽  
Factor System ◽  
Stem Cell Growth Factor

Dickkopf 1 (Dkk1) Regulates Hematopoietic Stem Cell Regeneration

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 1200-1200
Author(s):  
Heather A Himburg ◽  
Phuong L Doan ◽  
Xiao Yan ◽  
Mamle Quarmyne ◽  
Liman Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Hematopoietic Stem Cell ◽  
Systemic Administration ◽  
Hematopoietic Stem ◽  
University Patents ◽  
Duke University ◽  
Osteolineage Cells ◽  
Stem Cell Growth Factor

Abstract Bone marrow endothelial cells (BM ECs) have been shown to regulate HSC regeneration following myelosuppression. The role of osteolineage cells in regulating HSC regeneration remains less well understood. Here, we show that deletion of the pro-apoptotic genes, Bak and Bax, in osterix (Osx)-expressing osteoprogenitor cells promoted HSC regeneration and hematopoietic radioprotection of mice following total body irradiation (TBI). We identified Dkk1 to be enriched in the BM of radioprotected OsxCre;Bak1-/-;BaxFL/- mice and found that Bak /Bax-deficient osteolineage cells expressed increased levels of Dkk1 compared to Bax-expressing osteolineage cells (p=0.003). Treatment of irradiated BM HSCs with DKK1 in vitro significantly increased the recovery of phenotypic HSCs (p=0.0002), colony forming cells (CFCs)(p=0.003) and long-term repopulating HSCs compared to control cultures (p=0.009). Systemic administration of Dkk1 to lethally irradiated C57Bl6 mice accelerated the recovery of mature blood counts (p=0.008), BM HSCs (p=0.008) and progenitor cells (p=0.007). Furthermore, survival after lethal irradiation was markedly increased in Dkk1 treated mice (93%) compared to saline controls (27%; p=0.0004). Conversely, systemic administration of anti-Dkk1 antibody significantly delayed recovery of BM HSCs (p=0.002), peripheral white blood cells (p=0.0004), neutrophils (p<0.0001) and lymphocytes (p=0.002) in irradiated mice compared to irradiated, control mice. Dkk1 promoted HSC regeneration via suppression of reactive oxygen species (ROS) and inhibition of caspase activation in HSCs following irradiation. Dkk1 represents a novel, osteoprogenitor cell-derived paracrine factor which is necessary for normal hematopoietic regeneration following irradiation and can be therapeutically delivered to accelerate hematopoietic reconstitution. Disclosures Himburg: Duke University: Patents & Royalties: Patent Application for use of Pleiotrophin as a hematopoietic stem cell growth factor. Chute:C2 Regenerate: Equity Ownership; Duke University: Patents & Royalties: Application to use PTN as growth factor as hematopoietic stem cell growth factor.

A recurrent deletion in the KIT (mast/stem cell growth factor receptor) proto-oncogene is a frequent cause of human piebaldism

1993 ◽  
Vol 2 (9) ◽  
pp. 1499-1500 ◽  
Author(s):  
R.A. Spritz ◽  
Stuart A. Holmes ◽  
Susan Z. Berg ◽  
James J. Nordlund ◽  
Kazuyoshl Fukal
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Growth Factor Receptor ◽  
Stem Cell Growth Factor ◽  
Cell Growth Factor Receptor ◽  
Recurrent Deletion

scholarly journals A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction

2012 ◽  
Vol 79 (5) ◽  
pp. 673-677 ◽  
Author(s):  
Domenico G. Della Rocca ◽  
Bradley J. Willenberg ◽  
Leonardo F. Ferreira ◽  
Prateek S. Wate ◽  
John W. Petersen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Growth Factor Delivery ◽  
Alginate Hydrogel ◽  
Stem Cell Growth Factor

scholarly journals Correlation of fetal hemoglobin in different cancer patients and sickle cell anaemia: A review

2021 ◽  
Vol 12 (1) ◽  
pp. 396-400
Author(s):  
Ayesha Shahid ◽  
Jan Peerzada Fawad ullah
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Fetal Hemoglobin ◽  
Globin Chain ◽  
Adult Hemoglobin ◽  
Malignant Condition ◽  
Stem Cell Growth Factor

Fetal hemoglobin is the main hemoglobin during gestation period. But this globin chain is replaced and is taken over by adult hemoglobin. Sometimes this switch from fetal to adult fails to occur leading to production of fetal hemoglobin as in case of sickle cell anemia. It is also observed that fetal hemoglobin expression is also seen under malignant condition. In malignancy the spleen, liver as well as gut acquire its ability to produce fetal hemoglobin. Certain HbF cells inducing factor such as stem cell growth factor and interleukin -3 also promote HbF erythropoiesis. HbF cells are indicated as a biomarker of tumour cells implicated in many carcinomas observed by immunohisto chemical investigations.

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