scholarly journals Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients

2017 ◽  
Vol 13 (3) ◽  
pp. 905-908
Author(s):  
Ming-Yu Wang ◽  
Xian-Bin Wang ◽  
Xue-Hui Sun ◽  
Feng-Li Liu ◽  
Sheng-Chuan Huang
Keyword(s):  
Rheumatoid Arthritis ◽  
High Frequency ◽  
Doppler Ultrasonography ◽  
Color Doppler ◽  
Diagnostic Value ◽  
Color Doppler Ultrasonography ◽  
Antibody Testing ◽  
Cyclic Citrullinated Peptide ◽  
Peptide Antibody ◽  
Citrullinated Peptide

Anti-cyclic Citrullinated Peptide Antibody (Anti-CCP) and Diagnostic Value for Rheumatoid Arthritis

2014 ◽  
Vol 13 (1) ◽  
pp. 83 ◽  
Author(s):  
Mehmet Agilli ◽  
Safak Ekinci ◽  
Fevzi Aydin ◽  
Irfan Sener ◽  
Adem Parlak ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Diagnostic Value ◽  
Cyclic Citrullinated Peptide ◽  
Peptide Antibody ◽  
Citrullinated Peptide

scholarly journals Diagnostic value of anti-cyclic citrullinated peptide antibody combined with rheumatoid factor in rheumatoid arthritis in Asia: a meta-analysis

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110477
Author(s):  
Xiaochun Yang ◽  
Yue Cai ◽  
Bin Xue ◽  
Bo Zhang
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Likelihood Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Diagnostic Value ◽  
Cyclic Citrullinated Peptide ◽  
Peptide Antibody ◽  
Combined Detection ◽  
Citrullinated Peptide

Objective This meta-analysis explored the diagnostic value of anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) for rheumatoid arthritis (RA) in the Asian population. Methods Embase, Medline, Cochrane Library, Chinese Science and Technology Periodicals, China National Knowledge Infrastructure, and China Wanfang Databases were searched from 1 January 2000 to 1 February 2021 to collect studies on the combined detection of anti-CCP and RF for diagnosing RA. The sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), and negative likelihood ratio (−LR) were combined and analyzed. Summary receiver operating characteristic (SROC) curves were drawn. Results Twenty-four published papers were analyzed, including 21 combined in series and 8 combined in parallel. In the tandem analysis, the sensitivity = 0.64 [95% confidence interval (CI): 0.58–0.70], specificity = 0.97 (95%CI: 0.95–0.98), +LR = 19.70 (95%CI: 12.74–30.46), −LR = 0.37 (95%CI: 0.31–0.43), DOR = 53.43 (95%CI: 34.46–82.40), and area under the SROC curve = 0.89. In the parallel combination, the sensitivity = 0.87 (95%CI: 0.80–0.92), specificity = 0.76 (95%CI: 0.67–0.84), +LR = 3.68 (95%CI: 2.62–5.17), −LR = 0.17 (95%CI: 0.11–0.26), DOR = 21.56 (95%CI: 11.63–39.99), and area under the SROC curve = 0.89. Conclusion Anti-CCP and RF combined detection improves the diagnostic efficiency of RA, providing a potential strategy for early clinical screening in the Asian population. This trial was retrospectively registered in the INPLASY/Research Registry ( https: //inplasy.com/ ) with the registration number INPLASY202180106.

scholarly journals Study on the evaluation of rheumatoid arthritis via doppler ultrasonography and anti-cyclic citrullinated peptide antibody analysis

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Li-na Shang ◽  
Gui-xin Di ◽  
Feng-ju Wei ◽  
Zheng Zhang
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Doppler Ultrasonography ◽  
Severe Disease ◽  
Joint Involvement ◽  
Cyclic Citrullinated Peptide ◽  
Mild Disease ◽  
Number Of Patients ◽  
Peptide Antibody ◽  
Citrullinated Peptide

Objective: This study aims to discuss the value of ultrasonic analysis and anti-cyclic citrullinated peptide (CCP) antibody analysis in evaluating the state of rheumatoid arthritis (RA). Methods: This study was conducted during March 2016 to December 2016. Total 82 patients with RA who sought treatment in the Affiliated Hospital of Hebei University were included in this study. Data on ultrasonic and anti-CCP antibody, ESR, and RF were collected and compared. The RA patients were divided into two groups of mild disease activity (DAS28 ≤ 3.2) and moderate-severe disease activity (DAS28 > 3.2) to compare the changes in synovial thickness of joints. The changes of joint ultrasonography were also compared between positive and negative anti-CCP antibodies group. Results: It is found that the number of patients suffering from joint involvement in the negative anti-CCP antibody group was larger than that of the anti-CCP positive antibody group (P <0.05); the thickness of the synovium of joints of patients in the group with moderate-severe disease activity evaluated via ultrasonography was significantly larger than that of the group with mild disease activity (P <0.05). Conclusion: It is possible to observe the degree of disease activity dynamically by combining ultrasonography with anti-CCP antibody and make a better assessment of patients to facilitate treatment. doi: https://doi.org/10.12669/pjms.36.3.1492 How to cite this:Shang L, Di G, Wei F, Zhang Z. Study on the evaluation of rheumatoid arthritis via doppler ultrasonography and anti-cyclic citrullinated peptide antibody analysis. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1492 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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