scholarly journals Computer-assisted quantitative evaluation of bisphosphonate treatment for Paget's disease of bone using the bone scan index

2016 ◽  
Vol 12 (6) ◽  
pp. 3830-3836 ◽  
Author(s):  
Satoshi Nagano ◽  
Shunsuke Nakamura ◽  
Hirofumi Shimada ◽  
Masahiro Yokouchi ◽  
Takao Setoguchi ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Bone Scan ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Computer Assisted ◽  
Paget's Disease Of Bone ◽  
Bisphosphonate Treatment ◽  
Bone Scan Index

scholarly journals Paget's disease of bone

2006 ◽  
Vol 50 (4) ◽  
pp. 814-822 ◽  
Author(s):  
Luiz Griz ◽  
Gustavo Caldas ◽  
Cristina Bandeira ◽  
Viviane Assunção ◽  
Francisco Bandeira
Keyword(s):  
Biochemical Markers ◽  
Bone Scan ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
European Descent ◽  
Markers Of Bone Turnover ◽  
European Colonization ◽  
Genetic And Environmental Factors

Paget's disease of bone is a focal disorder of bone remodeling accompanied initially by an increase in bone resorption, followed by a disorganized and excessive formation of bone, leading to pain, fractures and deformities. It exhibits a marked geographical variation in its prevalence. In Brazil it predominantly affects persons of European descent. The majority of the reported cases of the disease in Brazil are from Recife, owing to its peculiar mixed European colonization over approximately four centuries. The etiology is complex and involves both genetic and environmental factors. The disease is often asymptomatic and diagnosis is usually based on biochemical markers of bone turnover, radionuclide bone scan and radiological examination. Bisphosphonates, in particular zoledronic acid, are regarded as the treatment of choice for Paget's disease of bone.

scholarly journals Randomized trial of intensive bisphosphonate treatment versus symptomatic management in paget's disease of bone

2009 ◽  
Vol 25 (1) ◽  
pp. 20-31 ◽  
Author(s):  
Anne L Langston ◽  
Marion K Campbell ◽  
William D Fraser ◽  
Graeme S MacLennan ◽  
Peter L Selby ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Bisphosphonate Treatment ◽  
Symptomatic Management

scholarly journals Paget’s disease of bone, biphosphonates and jaw osteonecrosis: a case report

NEMESIS ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 15
Author(s):  
Michele Magremanne ◽  
Anne Grysolle ◽  
Hervé Reychler
Keyword(s):  
Case Report ◽  
Paget’S Disease ◽  
Rare Event ◽  
Rare Condition ◽  
Osteonecrosis Of The Jaw ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Bisphosphonate Treatment ◽  
Oncologic Patients

Objective: Paget’s disease of bone is characterized by a focal increase in bone resorption and accelerated bone formation leading to a weaker and disorganised bone. Bisphosphonates (BPs) have been the treatment of choice of Paget’s disease since the 1990s. Medication related osteonecrosis of the jaw (MRONJ) is a rare event in non oncologic patients. We describe a rare case of  Paget’s disease involving the maxilla with osteonecrosis in a context of bisphosphonate treatment.   Case report: an 87-year-old woman presented with 4 episodes of bone necrosis in 15 years. In this case report there is a clear chronologic association between the occurrence of MRONJ and the administration of iv BP for Paget’s disease. Maxillofacial involvement of Paget’s disease occurs in less than 15% of cases. There is a lack of information in the literature about the association of MRONJ and Paget’s disease. Even if osteonecrosis of the jaw could be a consequence of the disease, in this case, it is more in relation to the BP treatment.   Conclusions: Although MRONJ might be considered a rare condition in Paget’s disease, patients prior to starting antiresorptive therapy and in particular iv BPs should have a complete dental examination and panoramic X-Ray.   Nemesis relevance: side effect of bisphosphonate treatment  

Pharmacogenomics of bisphosphonate treatment in Paget's disease of bone: retrospective and prospective analysis

2014 ◽  
Author(s):  
Daniela Merlotti ◽  
Fernando Gianfrancesco ◽  
Domenico Rendina ◽  
Riccardo Muscariello ◽  
Teresa Esposito ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Prospective Analysis ◽  
Paget's Disease Of Bone ◽  
Bisphosphonate Treatment
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