scholarly journals Severe pneumonia due to infection with Candida krusei in a case of suspected Middle East respiratory syndrome: A case report and literature review

2016 ◽  
Vol 12 (6) ◽  
pp. 4085-4088
Author(s):  
Mingming Tan ◽  
Junwei Wang ◽  
Peiyang Hu ◽  
Bin Wang ◽  
Wanghua Xu ◽  
...  
Keyword(s):  
Case Report ◽  
Middle East ◽  
Literature Review ◽  
Severe Pneumonia ◽  
Candida Krusei ◽  
Middle East Respiratory Syndrome

scholarly journals Coronavirus: Penyakit Lama, Virus Lama, Kemasan Baru

2020 ◽  
Vol 2 (1) ◽  
pp. 43
Author(s):  
Heru Wijono
Keyword(s):  
Middle East ◽  
Incubation Period ◽  
Respiratory Disease ◽  
Virus Strain ◽  
Severe Pneumonia ◽  
Middle East Respiratory Syndrome ◽  
Advanced Age ◽  
Acute Respiratory Disease

Abstract— Covid -19, a virus strain and a member of family with known member as Severe Acute Respiratory Disease (SARS) or Middle East Respiratory Syndrome (MERS), but having a potentially lethal differences in not readily recognized by our immunity. Classified as betacoronavirus, with incubation period up to 14 days, the sign and symptoms can be highly variable, from asymptomatic to mild to criticalin the form of severe pneumonia. Almost half the persons infected did not show any symptoms, but in cases of people with comorbidities such as advanced age, pregnancy, obesity or other certain diseases, could increase the likelihood of morbidity and even potentially fatal. Covid-19 has spread globally, including Indonesia, with a potentially increased number of cases, prevention in covid-19 protocol is a necessity. Keywords: Covid-19, SARS, symptoms, variable, prevention Abstrak— Covid-19, yang sebelumnya dikenal sebagai virus strain dari kelompok family yang sama dengan Severe Acute Respiratory Disease (SARS) atau Middle East Respiratory Syndrome (MERS), tapi memiliki fatalitas yang secara potensial lebih tinggi, karena bersiafat novel bagi sistem imunitas kita. Termasuk betacoronavirus, dengan masa inkubasi sampai dengan 14 hari, tanda dan gejala penyakit bisa sangat bervariasi, mulai dari asimtomatik, ringan sampai berat, dalam bentuk pneumonia berat. Hamper separuh penderita yang terinfeksi tidak menunjukkan gejala sama sekali, tapi pada penderita dengan komorbiditas seperti usia lanjut, kehamilan, obesitas atau penyakit kronis tertentu, resiko moribiditas dan mortalitas dapat meningkat. Covid-19 saat ini sudah menyebar ke seluruh dunia, termasuk Indonesia, dengan adanya potensi kenaikan kasus lebih banyak, pencegahan dalam bentuk protocol covid-19 bersifat mutlak diperlukan. Kata kunci: Covid-19, SARS, gejala, bervariasi, pencegahan

scholarly journals A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results

2016 ◽  
Vol 31 (4) ◽  
pp. 635 ◽  
Author(s):  
Ran-hui Cha ◽  
Seung Hee Yang ◽  
Kyung Chul Moon ◽  
Joon-Sung Joh ◽  
Ji Yeon Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Middle East ◽  
Kidney Biopsy ◽  
Middle East Respiratory Syndrome

scholarly journals COVID-19: только научные факты

2020 ◽  
pp. 2-22 ◽  
Keyword(s):  
Comparative Analysis ◽  
Middle East ◽  
Virus Infection ◽  
Literature Review ◽  
Clinical Manifestations ◽  
Middle East Respiratory Syndrome ◽  
Converting Enzyme ◽  
Scientific Publications ◽  
Pulmonary Tissue ◽  
High Virus

The article presents a literature review of scientific publications on the etiology, epidemiology, pathogenesis, clinical manifestations and treatment of a new corona virus infection COVID-19. The authors have carried out a comparative analysis of the infection caused by the virus SARS-CoV-2, with severe respiratory syndrome (ТОРС/SARS), caused by the virus SARS-CoV and Middle East respiratory syndrome caused by MERS-CoV. The authors described epidemiological and clinical peculiarities of COVID-19 associated with a high virus affinity to the molecule of agiotensin converting enzyme of the 2nd type in the human pulmonary tissue.

scholarly journals The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

2014 ◽  
Vol 95 (4) ◽  
pp. 874-882 ◽  
Author(s):  
Krystal L. Matthews ◽  
Christopher M. Coleman ◽  
Yvonne van der Meer ◽  
Eric J. Snijder ◽  
Matthew B. Frieman
Keyword(s):  
Middle East ◽  
Severe Pneumonia ◽  
Cell Types ◽  
Innate Immune ◽  
Middle East Respiratory Syndrome ◽  
Signalling Pathways ◽  
Type I ◽  
Accessory Proteins ◽  
Type I Ifn

The recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV), a betacoronavirus, is associated with severe pneumonia and renal failure. The environmental origin of MERS-CoV is as yet unknown; however, its genome sequence is closely related to those of two bat coronaviruses, named BtCoV-HKU4 and BtCoV-HKU5, which were derived from Chinese bat samples. A hallmark of highly pathogenic respiratory viruses is their ability to evade the innate immune response of the host. CoV accessory proteins, for example those from severe acute respiratory syndrome CoV (SARS-CoV), have been shown to block innate antiviral signalling pathways. MERS-CoV, similar to SARS-CoV, has been shown to inhibit type I IFN induction in a variety of cell types in vitro. We therefore hypothesized that MERS-CoV and the phylogenetically related BtCoV-HKU4 and BtCoV-HKU5 may encode proteins with similar capabilities. In this study, we have demonstrated that the ORF4b-encoded accessory protein (p4b) of MERS-CoV, BtCoV-HKU4 and BtCoV-HKU5 may indeed facilitate innate immune evasion by inhibiting the type I IFN and NF-κB signalling pathways. We also analysed the subcellular localization of p4b from MERS-CoV, BtCoV-HKU4 and BtCoV-HKU5 and demonstrated that all are localized to the nucleus.

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