scholarly journals Protective effect of berberine against oxidative stress-induced apoptosis in rat bone marrow-derived mesenchymal stem cells

2016 ◽  
Vol 12 (6) ◽  
pp. 4041-4048 ◽  
Author(s):  
Wangyang Li ◽  
Yamei Liu ◽  
Bin Wang ◽  
Yiwen Luo ◽  
Nianhong Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Induced Apoptosis ◽  
Rat Bone

Protective effect of [Pyr1]-apelin-13 on oxidative stress-induced apoptosis in hair cell-like cells derived from bone marrow mesenchymal stem cells

2019 ◽  
Vol 853 ◽  
pp. 25-32 ◽  
Author(s):  
Somayeh Niknazar ◽  
Hojjat-Allah Abbaszadeh ◽  
Hassan Peyvandi ◽  
Omidvar Rezaei ◽  
Hosna Forooghirad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Protective Effect ◽  
Hair Cell ◽  
Marrow Mesenchymal Stem Cells ◽  
Induced Apoptosis

scholarly journals The Antioxidant Effects of Ginger Extract on Bioavailability and Oxidative Stress-induced Apoptosis in Mesenchymal Stem Cells of Human Adipose Tissue and Rat Bone Marrow

2021 ◽  
Vol 24 (2) ◽  
pp. 216-229
Author(s):  
Sahar Dehghani ◽  
◽  
Leila Rouhi ◽  
Noosha Ziya Jahromi ◽  
Reza Dehghani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Human Adipose Tissue ◽  
Target Tissue ◽  
Ginger Extract ◽  
Induced Apoptosis ◽  
Rat Bone

Background and Aim: Proliferate potential differentiate into different cell lineages and high self-renewal of Mesenchymal Stem Cells (MSCs); thus, they are ideal tools for regenerative medicine. However, a leading problem is an oxidative stress in the target tissue and the apoptosis of transplanted stem cells before tissue repair. The pretreatment of stem cells with antioxidants may make them resistant to oxidative stress. Ginger is the main medicinal plant with antioxidant properties. This study explored the antioxidant effects of ginger extract on bioavailability and oxidative stress-induced apoptosis in human adipose tissue-derived mesenchymal stem cells and rat bone marrow examined. Methods & Materials: In this study, human adipose tissue-derived mesenchymal stem cells and rat bone marrow were cultured in a DMEM medium with 20% FBS. The explored cells were incubated for 4 and 6 hours for pretreatment with different concentrations of ginger extract (50, 100, 200, & 400 mg/mL); then, they were treated with 200 μM H2O2 for 2 hours. Bioavailability was analyzed by ELISA reader using an MTS kit and apoptosis was analyzed by flow cytometry using an Annexin V-FITC/PI kit into the manufacturer’s protocol at both times. The obtained data were analyzed by Analysis of Variance (ANOVA) using SPSS. Ethical Considerations: This study was approved by the Ethics Research Committee of Shahrekord Branch, Islamic Azad University (Code: IR.IAU.SHK.REC.1397.028). Results: The MTS results indicated a dose- and time-dependent manner increase in the bioavailability of human adipose tissue-derived mesenchymal treated stem cells. Ginger extract treatment also dose- and time-dependently decreased the rate of apoptosis in rat bone marrow mesenchymal stem cells. Conclusion: Ginger extract, by reducing the oxidative stress in mesenchymal stem cells, elevates their lifespan in the target tissue, and increases the efficiency of these cells in tissue regeneration.

scholarly journals Iron depletion with deferoxamine protects bone marrow-derived mesenchymal stem cells against oxidative stress-induced apoptosis

2020 ◽  
Vol 25 (6) ◽  
pp. 1059-1069 ◽  
Author(s):  
Nasrin Khoshlahni ◽  
Mohsen Sagha ◽  
Tooba Mirzapour ◽  
Mahin Nikougoftar Zarif ◽  
Mohammad Mohammadzadeh-Vardin
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Iron Depletion ◽  
Induced Apoptosis

Rosmarinic acid protects on rat bone marrow mesenchymal stem cells from hydrogen peroxide-induced apoptosis

2018 ◽  
Vol 20 (6) ◽  
pp. 570-580 ◽  
Author(s):  
Li-Zhen Lin ◽  
Huan-Huan Chen ◽  
Zhou-Xi Lei ◽  
Yun-Rong Li ◽  
Chun-Hua Zhou ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rosmarinic Acid ◽  
Marrow Mesenchymal Stem Cells ◽  
Induced Apoptosis ◽  
Rat Bone
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