scholarly journals Angiogenin is upregulated during the alloreactive immune response and has no effect on the T-cell expansion phase, whereas it affects the contraction phase by inhibiting CD4+ T-cell apoptosis

2016 ◽  
Vol 12 (5) ◽  
pp. 3471-3475 ◽  
Author(s):  
Theodoros Eleftheriadis ◽  
Georgios Pissas ◽  
Maria Sounidaki ◽  
Nikolaos Antoniadis ◽  
Georgia Antoniadi ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Apoptosis ◽  
Cell Expansion ◽  
Cd4 T Cell ◽  
Expansion Phase ◽  
Contraction Phase ◽  
T Cell Apoptosis ◽  
T Cell Expansion

scholarly journals Locally produced C5a binds to T cell–expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

Blood ◽  
2008 ◽  
Vol 112 (5) ◽  
pp. 1759-1766 ◽  
Author(s):  
Peter N. Lalli ◽  
Michael G. Strainic ◽  
Min Yang ◽  
Feng Lin ◽  
M. Edward Medof ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Apoptosis ◽  
Cell Expansion ◽  
Immune Cell ◽  
Regulatory Protein ◽  
T Cell Apoptosis ◽  
T Cell Expansion

Abstract Our recent studies have shown that immune cell–produced complement provides costimulatory and survival signals to naive CD4+ T cells. Whether these signals are similarly required during effector cell expansion and what molecular pathways link locally produced complement to T-cell survival were not clarified. To address this, we stimulated monoclonal and polyclonal T cells in vitro and in vivo with antigen-presenting cells (APCs) deficient in the complement regulatory protein, decay accelerating factor (DAF), and/or the complement component C3. We found that T-cell expansion induced by DAF-deficient APCs was augmented with diminished T-cell apoptosis, whereas T-cell expansion induced by C3−/− APCs was reduced because of enhanced T-cell apoptosis. These effects were traced to locally produced C5a, which through binding to T cell–expressed C5aR, enhanced expression of Bcl-2 and prevented Fas up-regulation. The results show that C5aR signal transduction in T cells is important to allow optimal T-cell expansion, as well as to maintain naive cell viability, and does so by suppressing programmed cell death.

scholarly journals MiR-let-7i inhibits CD4+ T cell apoptosis in patients with acute coronary syndrome

2021 ◽  
Vol 30 (8) ◽  
pp. 0-0
Author(s):  
lijuan huang ◽  
boxin zhao ◽  
zhiyong zhang ◽  
lin gui ◽  
yingyu xiang ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
T Cell ◽  
Cell Apoptosis ◽  
Cd4 T Cell ◽  
T Cell Apoptosis ◽  
Coronary Syndrome

scholarly journals Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice

2015 ◽  
Vol 12 (1) ◽  
pp. 40 ◽  
Author(s):  
Rebecca K Sheean ◽  
Richard H Weston ◽  
Nirma D Perera ◽  
Angela D’Amico ◽  
Stephen L Nutt ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Expansion ◽  
Disease Onset ◽  
Cd4 T Cell ◽  
Mutant Sod1 ◽  
T Cell Expansion ◽  
Stimulation Of

MP65-06 INTRAVESICAL BCG INDUCES CD4+ T CELL EXPANSION BUT NOT ACTIVATION IN A CLINICALLY RELEVANT IMMUNE COMPETENT MODEL OF BLADDER CANCER

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Max Kates ◽  
Thomas Nirschl ◽  
Niklai Sopko ◽  
Hotaka Matsui ◽  
Alexander Baras ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
T Cell ◽  
Cell Expansion ◽  
Cd4 T Cell ◽  
Intravesical Bcg ◽  
T Cell Expansion

scholarly journals Combination of IL-10 and IL-2 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in humanized mice

Heliyon ◽  
2017 ◽  
Vol 3 (4) ◽  
pp. e00276 ◽  
Author(s):  
Sojan Abraham ◽  
Hua Guo ◽  
Jang-gi Choi ◽  
Chunting Ye ◽  
Midhun Ben Thomas ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Expansion ◽  
Cd4 T Cell ◽  
Humanized Mice ◽  
T Cell Expansion

Polycomb chromobox (Cbx) 7 modulates activation-induced CD4+ T cell apoptosis

2014 ◽  
Vol 564 ◽  
pp. 184-188 ◽  
Author(s):  
Jian Li ◽  
Yang Li ◽  
Yinyin Cao ◽  
Meifen Yuan ◽  
Zhengfeng Gao ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Apoptosis ◽  
Cd4 T Cell ◽  
T Cell Apoptosis

Abstract 1611: Intravesical BCG induces CD4 T Cell expansion in an immune competent model of bladder cancer

2017 ◽  
Author(s):  
Max Kates ◽  
Thomas Nirschl ◽  
Nikolai Sopko ◽  
Noah Hahn ◽  
David McConkey ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
T Cell ◽  
Cell Expansion ◽  
Cd4 T Cell ◽  
Intravesical Bcg ◽  
T Cell Expansion
Sign in / Sign up

Export Citation Format

Share Document