scholarly journals Part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration in the treatment of severe acute liver failure

2016 ◽  
Vol 12 (4) ◽  
pp. 2582-2584 ◽  
Author(s):  
Maoqin Li ◽  
Zhidong Wang ◽  
Yining Wang ◽  
Changhong Du ◽  
Songhai Li ◽  
...  
2018 ◽  
Vol 47 (1-3) ◽  
pp. 120-125 ◽  
Author(s):  
Yu Zhang ◽  
Liang Li ◽  
Xiaole Zhang ◽  
Wen Xu ◽  
Qun Guo ◽  
...  

Wilsonian crisis (hemolytic crisis and acute liver failure [ALF] in Wilson’s disease) is fatal and almost all patients ultimately need a timely liver transplantation to save their lives. How to safely pass the critical period to liver transplantation is still a big challenge to doctors especially to pediatricians facing more difficult situations in blood purification. Here, we report about a 7-year-old child (weight 21 kg) presenting with severe hemolysis and impending ALF that made a rapid recovery with prompt initiation of plasmapheresis combined with continuous plasma filtration adsorption (CPFA) and chelation therapy. Rapidly efficient removal of copper, bilirubin, and albumin-binding toxins by hybrid blood purification alleviated hemolysis and liver injury and successfully bridged the patient over the critical period to late liver transplantation. Moreover, a review of the literature was performed examining the use of plasmapheresis, molecular adsorbent recirculation system, single-pass albumin dialysis, and continuous veno-venous hemodiafiltration in Wilson disease. The experience of our case points to that plasmapheresis combined with CPFA treatment can improve clinical symptoms and bridge children over through Wilsonian crisis to late live transplantation, and CPFA treatment is feasible and safe in children weighing more than 20 kg.


Critical Care ◽  
2014 ◽  
Vol 18 (Suppl 1) ◽  
pp. P399
Author(s):  
Y Eguchi ◽  
H Nakae ◽  
T Furuya ◽  
M Isono ◽  
Y Kishi ◽  
...  

2001 ◽  
Vol 29 (7) ◽  
pp. 1386-1392 ◽  
Author(s):  
Tomohito Sadahiro ◽  
Hiroyuki Hirasawa ◽  
Shigeto Oda ◽  
Hidetoshi Shiga ◽  
Kazuya Nakanishi ◽  
...  

2015 ◽  
Vol 19 (4) ◽  
pp. 349-354 ◽  
Author(s):  
Hiroshi Yamamoto ◽  
Hajime Nakae ◽  
Yoshitaka Uji ◽  
Kazuhisa Maeda ◽  
Tohru Tani ◽  
...  

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