scholarly journals A 3-year follow-up study of β-cell function in patients with early-onset type 2 diabetes

2016 ◽  
Vol 12 (2) ◽  
pp. 1097-1102 ◽  
Author(s):  
Shaoling Zhou ◽  
Xiaomei Meng ◽  
Shuyan Wang ◽  
Ruizhen Ren ◽  
Weikai Hou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Cell Function ◽  
Β Cell ◽  
Onset Type ◽  
Follow Up Study ◽  
Β Cell Function

Serum complement C3 and islet β-cell function in patients with type 2 diabetes: A 4.6-year prospective follow-up study

Endocrine ◽  
2019 ◽  
Vol 67 (2) ◽  
pp. 321-330
Author(s):  
Jian-bin Su ◽  
Yun-Yu Wu ◽  
Feng Xu ◽  
Xing Wang ◽  
Hong-li Cai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cell Function ◽  
Complement C3 ◽  
Serum Complement ◽  
Β Cell ◽  
Follow Up Study ◽  
Β Cell Function

The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes

2013 ◽  
Vol 80 (4) ◽  
pp. 545-553 ◽  
Author(s):  
Amalia Gastaldelli ◽  
Robert G. Brodows ◽  
David D'Alessio
Keyword(s):  
Type 2 Diabetes ◽  
Cell Function ◽  
Β Cell ◽  
Onset Type ◽  
Β Cell Function ◽  
New Onset

scholarly journals Islet β-Cell Function Following 4.4-Year Insulin Injection in Chinese Elderly Patients with Type 2 Diabetes Mellitus

2020 ◽  
Author(s):  
Wei Ling ◽  
HUANG Yi ◽  
XIAO Yan-Hua ◽  
HUANG Yan-Mei ◽  
OU Yang-Fu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Elderly Patients ◽  
Cell Function ◽  
Β Cell ◽  
Chinese Elderly ◽  
C Peptide ◽  
Β Cell Function

Abstract Background The aim of this study was to scrutinize changes of islet β-cell function in Chinese elderly patients with type 2 diabetes mellitus (T2DM) after insulin versus oral anti-diabetic (OAD) treatments. Methods In this prospective study, islet β-cell function was determined by oral glucose tolerance test-derived fasting C-peptide, maximal C-peptide, C-peptide area under the curve (AUC c-pep ) and fasting c-pep /fasting glu , maximal c-pep /maximal glu , AUC c-pep /AUC glu . Differences in β-cell function indices between baseline and follow-up were compared among insulin monotherapy, OAD monotherapy and combined therapies. Results From 2009 to 2017, 419 elderly patients (men: 51.1%) with T2DM (insulin monotherapy, n=105; OAD monotherapy, n=172; insulin + OAD, n=142) had undergone baseline and follow-up β-cell function assessment after a mean observation of 4.4 (range, 3.0 - 7.2) years. Overall, islet β-cell function indices were decreased in all the three groups: insulin (fasting C-peptide: p=0.002; maximal C-peptide: p=0.005; fasting c-pep /fasting glu : p=0.015; maximal c-pep /maximal glu : p=0.031), OAD (fasting C-peptide: p=0.026; maximal C-peptide: p=0.013; fasting c-pep /fasting glu : p=0.025; maximal c-pep /maximal glu : p=0.029), insulin + OAD (fasting C-peptide: p<0.001; maximal C-peptide: p<0.001; fasting c-pep /fasting glu : p=0.015; maximal c-pep /maximal glu : p=0.019). No significant differences of reduction were observed among the three groups regarding the fasting C-peptide (p=0.437), fastingc-pep/fastingglu (p=0.598), maximalc-pep/maximalglu (p=0.756), AUCc-pep (p=0.856) and AUCc-pep/AUCglu (p=0.912). However, the OAD treatment group had showed a less reduction level over insulin or insulin + OAD treatment. Conclusions In Chinese elderly patients with T2DM, islet β-cell function indices progressively decline regardless of insulin supplement or insulin plus OAD treatments. However, patients with OAD monotherapy may provide better β-cell function preservation than the insulin treatments.

scholarly journals Serum Amylase Levels in Relation to Islet β Cell Function in Patients with Early Type 2 Diabetes

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162204 ◽  
Author(s):  
Lei Zhuang ◽  
Jian-bin Su ◽  
Xiu-lin Zhang ◽  
Hai-yan Huang ◽  
Li-hua Zhao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Serum Amylase ◽  
Cell Function ◽  
Early Type ◽  
Β Cell ◽  
Β Cell Function
Sign in / Sign up

Export Citation Format

Share Document