scholarly journals Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma

2016 ◽  
Vol 12 (1) ◽  
pp. 377-383 ◽  
Author(s):  
QI CHEN ◽  
BIN CAO ◽  
NING NAN ◽  
YU WANG ◽  
XU ZHAI ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Poor Survival ◽  
Cell Renal Carcinoma ◽  
Elevated Expression

scholarly journals piRNA-31115 Promotes Cell Proliferation and Invasion via PI3K/AKT Pathway in Clear Cell Renal Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xinghua Du ◽  
Haomin Li ◽  
Xuexia Xie ◽  
Liping Shi ◽  
Fan Wu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Function Analysis ◽  
Clear Cell Renal Carcinoma ◽  
Germline Development ◽  
Mesenchymal Transition ◽  
Normal Tissues ◽  
Cell Renal Carcinoma ◽  
Ccrcc Cell

PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that play important roles in germline development and carcinogenesis. In this study, we used the deep sequencing of small RNA Transcriptome to explore the piRNA expression in six clear cell renal carcinoma (ccRCC) tissues and matched adjacent normal tissues and found that six piRNAs were upregulated and sixteen were downregulated in ccRCC tissues. Among them, piRNA-31115 (NCBI accession number: DQ571003) was the most upregulated piRNA in ccRCC tissues compared with matched adjacent normal tissues. Quantitative real-time PCR (qRT-PCR) was used to confirm piR-31115 expression in other ccRCC tissues ( n = 40 ) and ccRCC cell lines. Besides, function analysis demonstrated that silencing of piR-31115 inhibited ccRCC cell proliferation, motility, and invasiveness. Mechanistic investigations showed that piRNA-31115 may activate epithelial-mesenchymal transition (EMT) via the PI3K/AKT signaling pathway. Hence, piR-31115 may represent an oncogene in the development of ccRCC.

scholarly journals High Expression of KCa3.1 in Patients with Clear Cell Renal Carcinoma Predicts High Metastatic Risk and Poor Survival

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0122992 ◽  
Author(s):  
Maj Rabjerg ◽  
Aida Oliván-Viguera ◽  
Lars Koch Hansen ◽  
Line Jensen ◽  
Linda Sevelsted-Møller ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clear Cell ◽  
High Expression ◽  
Clear Cell Renal Carcinoma ◽  
Poor Survival ◽  
Cell Renal Carcinoma ◽  
Metastatic Risk

1651: Molecular Prognostic Modeling Using Protein Expression Profile in Clear Cell Renal Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 436-436 ◽  
Author(s):  
Hyung L. Kim ◽  
David B. Seligson ◽  
Nicolette Janzen ◽  
Matthew H. Bui ◽  
Robert A. Figlin ◽  
...  
Keyword(s):  
Protein Expression ◽  
Expression Profile ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Protein Expression Profile ◽  
Cell Renal Carcinoma ◽  
Prognostic Modeling

scholarly journals The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

Oncogene ◽  
2007 ◽  
Vol 26 (45) ◽  
pp. 6499-6508 ◽  
Author(s):  
J S P Yuen ◽  
M E Cockman ◽  
M Sullivan ◽  
A Protheroe ◽  
G D H Turner ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

scholarly journals The Influence of the Extremely Low Frequency Electromagnetic Field on Clear Cell Renal Carcinoma

2021 ◽  
Vol 22 (3) ◽  
pp. 1342
Author(s):  
Aleksandra Cios ◽  
Martyna Ciepielak ◽  
Wanda Stankiewicz ◽  
Łukasz Szymański
Keyword(s):  
Electromagnetic Field ◽  
Cancer Cells ◽  
Cell Lines ◽  
Renal Carcinoma ◽  
Clear Cell ◽  
Low Frequency ◽  
Inhibitory Effect ◽  
Hek293 Cells ◽  
Clear Cell Renal Carcinoma ◽  
Cell Renal Carcinoma

The development of new technologies and industry is conducive to the increase in the number and variety of electromagnetic field (EMF) sources in our environment. The main sources of EMF are high-voltage lines, household appliances, audio/video devices, mobile phones, radio stations, and radar devices. In the growing use of electronic devices, scientists are increasingly interested in the effects of EMF on human health. Even though many studies on the effects of EMF have already been carried out, none of them has shown a significant effect on mammals, including humans. Moreover, it is not entirely clear how EMF influences cell behavior. The International Agency for Research on Cancer on 31 May 2011, classified PEM as a possible carcinogenic factor. This study aimed to investigate the effect of the electromagnetic field on morphological and functional changes in clear cell renal carcinoma. The research was carried out on in vitro cultures of four cell lines: HEK293, 786-O 769-P, and Caki1. The results of the research showed that the EMF of low frequency had a slight effect on the viability of cells. EMF, which induced cell arrest in the G1 phase, increased the number of early apoptotic cells and decreased the number of viable cells in the 786-O line. EMF did not affect the proliferation and viability of HEK293 cells. Extreme low-frequency EMF (ELF-EMF) also showed an inhibitory effect on the migration and metastatic properties of clear cell kidney cancer cells. Moreover, shortly after the end of ELF-EMF exposure, significant increases in ROS levels were observed in all tested cell lines. As part of the work, it was shown that low-frequency EMF shows an inhibitory effect on the proliferation of primary cancer cells, diminishing their migratory, invasive, and metastatic abilities. It also increases the apoptosis of cancer cells and the amount of reactive oxygen species. Based on the results of our research, we want to point up that the effect of ELF-EMF depends on a specific metabolic state or at a specific stage in the cell cycle of the cells under study.

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