scholarly journals Rhubarb attenuates blood-brain barrier disruption via increased zonula occludens-1 expression in a rat model of intracerebral hemorrhage

2016 ◽  
Vol 12 (1) ◽  
pp. 250-256 ◽  
Author(s):  
YANG WANG ◽  
FAN PENG ◽  
GUI XIE ◽  
ZE-QI CHEN ◽  
HAI-GANG LI ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Blood Brain Barrier ◽  
Rat Model ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Zonula Occludens ◽  
Blood Brain ◽  
Zonula Occludens 1 ◽  
Brain Barrier Disruption

scholarly journals Blood-brain barrier disruption and angiogenesis in a rat model for neurocysticercosis

2018 ◽  
Vol 97 (2) ◽  
pp. 137-148 ◽  
Author(s):  
Rogger P. Carmen-Orozco ◽  
Danitza G. Dávila-Villacorta ◽  
Yudith Cauna ◽  
Edson G. Bernal-Teran ◽  
Leandra Bitterfeld ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Rat Model ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

Intracerebral Hemorrhage and Diabetes Mellitus: Blood-Brain Barrier Disruption, Pathophysiology, and Cognitive Impairments

2021 ◽  
Vol 20 ◽  
Author(s):  
Ghaith A. Bahadar ◽  
Zahoor A Shah
Keyword(s):  
Diabetes Mellitus ◽  
Intracerebral Hemorrhage ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Comorbid Condition ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Impact

: There is a surge in diabetes incidence with an estimated 463 million individuals been diagnosed worldwide. Diabetes Mellitus (DM) is a major stroke-related comorbid condition that increases the susceptibility of disabling post-stroke outcomes. Although less common, intracerebral hemorrhage (ICH) is the most dramatic subtype of stroke that is associated with higher mortality, particularly in DM population. Previous studies have focused mainly on the impact of DM on ischemic stroke. Few studies have focused on impact of DM on ICH and discussed the blood-brain barrier disruption, brain edema, and hematoma formation. However, more recently, investigating the role of oxidative damage and reactive oxygen species (ROS) production in preclinical studies involving DM-ICH animal models has gained attention. But, little is known about the correlation between neuroinflammatory processes, glial cells activation, and peripheral immune cell invasion with DM-ICH injury. DM and ICH patients experience impaired abilities in multiple cognitive domains by relatively comparable mechanisms, which could get exacerbated in the setting of comorbidities. In this review, we discuss both the pathology of DM as a comorbid condition for ICH and the potential molecular therapeutic targets for the clinical management of the ICH and its recovery.

NF-κB mediates early blood-brain barrier disruption in a rat model of traumatic shock

2019 ◽  
Vol 86 (2) ◽  
pp. 240-249 ◽  
Author(s):  
Zhe Deng ◽  
Dehong Liu ◽  
Tingping Fu ◽  
Wenqiang Jiang ◽  
Min Qiu ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Rat Model ◽  
Traumatic Shock ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption
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