scholarly journals Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing

2016 ◽  
Vol 12 (1) ◽  
pp. 45-50 ◽  
Author(s):  
QIANG LI ◽  
YANPING GUO ◽  
FEIFEI CHEN ◽  
JING LIU ◽  
PEISHENG JIN
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Cell Survival ◽  
Stromal Cell ◽  
Chronic Wound ◽  
Human Adipose Tissue ◽  
Stem Cell Survival ◽  
Stromal Cell Derived Factor

Nuclear Argonaute 2 regulates adipose tissue-derived stem cell survival through direct control of miR10b and selenoprotein N1 expression

Aging Cell ◽  
2011 ◽  
Vol 10 (2) ◽  
pp. 277-291 ◽  
Author(s):  
Bong Sun Kim ◽  
Jin Sun Jung ◽  
Jin Hwa Jang ◽  
Kyung Sun Kang ◽  
Soo Kyung Kang
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Cell Survival ◽  
Direct Control ◽  
Argonaute 2 ◽  
Stem Cell Survival

CD271 promotes STZ-induced diabetic wound healing and regulates epidermal stem cell survival in the presence of the pTrkA receptor

2019 ◽  
Vol 379 (1) ◽  
pp. 181-193
Author(s):  
Min Zhang ◽  
Rui Zhang ◽  
Xiaohong Li ◽  
Yongqian Cao ◽  
Kaifeng Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cell Survival ◽  
Diabetic Wound ◽  
Epidermal Stem Cell ◽  
Stem Cell Survival ◽  
Diabetic Wound Healing

scholarly journals Distinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation, and Self-Renewal

Cell Reports ◽  
2014 ◽  
Vol 7 (6) ◽  
pp. 1956-1967 ◽  
Author(s):  
Stefan Wohrer ◽  
David J.H.F. Knapp ◽  
Michael R. Copley ◽  
Claudia Benz ◽  
David G. Kent ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Stromal Cell ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Survival

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

scholarly journals Continuous Delivery of Stromal Cell-Derived Factor-1 from Alginate Scaffolds Accelerates Wound Healing

2010 ◽  
Vol 19 (4) ◽  
pp. 399-408 ◽  
Author(s):  
Sina Y. Rabbany ◽  
Joseph Pastore ◽  
Masaya Yamamoto ◽  
Tim Miller ◽  
Shahin Rafii ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stromal Cell ◽  
Wound Closure ◽  
Tissue Injury ◽  
Unmet Need ◽  
Novel Therapy ◽  
Yorkshire Pigs ◽  
Stromal Cell Derived Factor

Proper wound diagnosis and management is an increasingly important clinical challenge and is a large and growing unmet need. Pressure ulcers, hard-to-heal wounds, and problematic surgical incisions are emerging at increasing frequencies. At present, the wound-healing industry is experiencing a paradigm shift towards innovative treatments that exploit nanotechnology, biomaterials, and biologics. Our study utilized an alginate hydrogel patch to deliver stromal cell-derived factor-1 (SDF-1), a naturally occurring chemokine that is rapidly overexpressed in response to tissue injury, to assess the potential effects SDF-1 therapy on wound closure rates and scar formation. Alginate patches were loaded with either purified recombinant human SDF-1 protein or plasmid expressing SDF-1 and the kinetics of SDF-1 release were measured both in vitro and in vivo in mice. Our studies demonstrate that although SDF-1 plasmid- and protein-loaded patches were able to release therapeutic product over hours to days, SDF-1 protein was released faster (in vivo Kd 0.55 days) than SDF-1 plasmid (in vivo Kd 3.67 days). We hypothesized that chronic SDF-1 delivery would be more effective in accelerating the rate of dermal wound closure in Yorkshire pigs with acute surgical wounds, a model that closely mimics human wound healing. Wounds treated with SDF-1 protein ( n = 10) and plasmid ( n = 6) loaded patches healed faster than sham ( n = 4) or control ( n = 4). At day 9, SDF-1-treated wounds significantly accelerated wound closure (55.0 ± 14.3% healed) compared to nontreated controls (8.2 ± 6.0%, p < 0.05). Furthermore, 38% of SDF-1-treated wounds were fully healed at day 9 (vs. none in controls) with very little evidence of scarring. These data suggest that patch-mediated SDF-1 delivery may ultimately provide a novel therapy for accelerating healing and reducing scarring in clinical wounds.

The enhancement of neural stem cell survival and growth by coculturing with expanded sertoli cells in vitro

2011 ◽  
Vol 28 (1) ◽  
pp. 196-205 ◽  
Author(s):  
Bingyang Shi ◽  
Lei Deng ◽  
Xiaolin Shi ◽  
Sheng Dai ◽  
Hu Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Neural Stem Cell ◽  
Sertoli Cells ◽  
Stem Cell Survival ◽  
Survival And Growth

Adult Stem Cell Survival Strategies

2012 ◽  
pp. 383-404 ◽  
Author(s):  
Melanie Rodrigues ◽  
Linda Griffith ◽  
Alan Wells
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Adult Stem Cell ◽  
Survival Strategies ◽  
Stem Cell Survival
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