scholarly journals Effect of electroacupuncture on gastric interstitial cells of Cajal in a rat model of diabetic gastroparesis

2016 ◽  
Vol 11 (6) ◽  
pp. 2489-2494 ◽  
Author(s):  
GUOHUA LIN ◽  
JIAWEI ZHANG ◽  
LIXIA LI ◽  
ZHUOCHENG ZOU ◽  
CHUYUN CHEN ◽  
...  
Keyword(s):  
Rat Model ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Diabetic Gastroparesis ◽  
Cells Of Cajal

scholarly journals Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis

Diabetes ◽  
2000 ◽  
Vol 49 (10) ◽  
pp. 1731-1739 ◽  
Author(s):  
T. Ordog ◽  
I. Takayama ◽  
W. K. Cheung ◽  
S. M. Ward ◽  
K. M. Sanders
Keyword(s):  
Murine Model ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Diabetic Gastroparesis ◽  
Cells Of Cajal

scholarly journals Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal

2017 ◽  
Vol 37 (5) ◽  
Author(s):  
Shu Yang ◽  
Bo Wu ◽  
Haimei Sun ◽  
Tingyi Sun ◽  
Kai Han ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Interstitial Cells Of Cajal ◽  
Serum Insulin ◽  
Smooth Muscles ◽  
Interstitial Cells ◽  
Diabetic Gastroparesis ◽  
Cholinergic Neurones ◽  
Cells Of Cajal ◽  
Type 1 Dm

Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1). Despite the fact that insulin treatment not glycemic control potently accelerated gastric emptying in type 1 DM patients, the role of insulin/InsR and IGF-1/IGF-1R signaling in diabetic gastroparesis remains incompletely elucidated. In the present study, type 1 DM mice were established and treated with insulin or Voglibose for 8 weeks. The gastric emptying was delayed from DM week 4 when the gastric InsR and IGF-1R were declined. Meanwhile, the gastric choline acetyltransferase (ChAT) was significantly reduced and the myenteric cholinergic neurones and their fibers were significantly diminished. The production of stem cell factor (SCF) was dramatically repressed in the gastric smooth muscles in DM week 6. TWereafter, interstitial cells of Cajal (ICC) were clearly lost and their networks were impaired in DM week 8. Significantly, compared with Voglibose, an 8-week treatment with insulin more efficiently delayed diabetic gastroparesis development by protecting the myenteric cholinergic neurones and ICC. In conclusion, diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin/InsR and IGF-1/IGF-1R signaling. Insulin therapy in the early stage may delay diabetic gastroparesis.

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